Drug-drug interaction is an important issue for the development of safe pharmaceutical drugs. Propranolol is a non-selective, competitive antagonist at beta-adrenergic receptors. Propranolol is used to control hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris and hypertrophic cardiomyopathy. Also, it is used to control symptoms of sympathetic overactivity in management of hyperthyroidism, anxiety disorders and tremor. Phenytoin is a voltage-gated sodium channel blocker, it is a major anti-convulsant drug that is very effective in controlling a wide variety of seizure disorders. In this study, elevated plus maze test was applied using five groups of male Albino mice, where each group consists of six mice. The first group is control and given 01.0% tween 80 with a dose of 5.0 ml/kg, the second group received propranolol 10 mg/kg, the third group received phenytoin 20 mg/kg, the fourth group received a combination of propranolol and phenytoin and the fifth group received diazepam (1.0 mg/kg) as a standard. It was found that propranolol alone produces anti-anxiety effect which is abolished when administered with phenytoin. Thus, the combined treatment of propranolol and phenytoin showed no significant difference compared to phenytoin alone or propranolol alone. It can be concluded that propranolol has anti-anxiety like effect an phenytoin antagonizes the propranolol anxiolytic effect when administered together. Propranolol, phenytoin and the combination of both decrease the spontaneous motor activity of mice. Propranolol and phenytoin partially antagonize each other on the spontaneous motor activity.

Mediterranean journal of pharmacy and pharmaceutical sciences

Justicia carnea, a plant rich in bioactive compounds, has traditionally been used as a haemoglobin booster by herbal practitioners in rural areas of Edo State of Nigeria. In this study, the methanol leaves extract of Justicia carnea was investigated for its antisickling potential in hemoglobin SS (HbSS) in-vitro by sodium metabisulphite assay and characterized by Gas Chromatography-Mass Spectrometry (GC-MS) and High-Performance Liquid Chromatography (HPLC). Terpenoids, saponins, glycosides, phenolics, flavonoids and alkaloids were present except tannins. Photomicrograph examinations revealed a reduction of sickle cells with a percentage decrease from 37.50%, and 22.22% down to 3.85% with 100 mg/mL crude extract of Justicia carnea at three durations, respectively. Detected compounds from Gas Chromatography-Mass Spectrometry included hexadecanoic acid methyl ester (Retention time (Rt): 21.46, 05.99%) and 9,12-octadecadienoic acid, methyl ester (Rt: 23.567, 02.59%) while the major constituent was phytol (Rt: 23.741, 67.28%). While kaempferol (Rt: 17.23, 16.72%) was the major component from High-Performance Liquid Chromatography quantification among resveratrol (Rt: 3.7, 13.85%), gallic acid (Rt: 5.88, 3.55%), Justicinol (Rt: 11.85, 01.34%) and phytic acid (Rt 5.06, 01.43 %). These compounds have been cited as physiological agents that reduce inflammation, and oxidative stress and potentially prolong the lifespan of cells across species. The antisickling results from this study corroborate and support the traditional use of the plant in treating patients with sickle cell anemia.

Mediterranean journal of pharmacy and pharmaceutical sciences

Human being has lot of virtual mask in their behaviour (mind or brain). By the way of probability study alone, be able to find a person’s loyalty through their emotions, stress of speech, way of expressions and so on. It is not a novel technique to this world. The judgement and the hearings are finalizing in accordance to passed parameters (questions, transparent as well hidden test) and the result. Artificial Neural Network (ANN) is one of the best methods meant for speech stress analysing based cheap lie detection for the loyalty test. To show the results, polygraph is a comprehensible demonstration oriented approach. These methods are already used by the insurance fraud investigations and police. Through an individual’s stress (stress percentage or else range) voice as well their emotions are able to detect the loyalty. Lie detection techniques require being extremely confidential and dynamic. For the reason that voice stress analysis (VSA) parameters have to be an encrypted for avoiding speech practise with testing tool. Here this paper, outlooks by using for predicting the liars through Speech VSA.

Dr h shaheen

2-Pyrazolines are well known, and important nitrogen-containing five-membered heterocyclic compounds which belong to the family of azoles and have been found to possess considerable activities, like anticancer, antibacterial, antifungal, immunosuppressant and antiamoebic activity. In the present work, ten novel pyrazolines were prepared from chalcones, characterized and evaluated for their antibacterial activity against Staphylococcus aureus and Escherichia coli using Ciprofloxacin as standard and using DMSO as a solvent. Their activity was evaluated by measuring the zone of inhibition in mm. All the compounds exhibited antibacterial activity against Staphylococcus aureus and Escherichia coli. Among ten derivatives of compounds synthesized, the derivative with 2-chloro and 4-chloro substituted phenyl rings attached to pyrazolines exhibited the highest activity against both types of organisms. The derivatives with an unsubstituted phenyl group attached to pyrazolines exhibited comparatively less activity. Thus it can be concluded that pyrazolines containing substituted phenyl groups are effective broad spectrum antibacterial agents, and they can be developed as effective antibacterial agents.

Vinod b

To the editor, Umbilical venous catheter (UVC) is a widely used venous access device in neonates of any gestational age due to the immediate accessibility of the umbilical vein and the simplicity of the procedure of its placement. Several complications of UVC have been reported, including the thrombotic and infective ones, its dislodgement, and embolization. [1] Retained UVC is an uncommon complication and needs prompt intervention to prevent its migration. We present a case of retained UVC and the algorithm for managing such cases.

Karishma

Mano Matram Jagat; Mano Kalpitam Jagat - (“the world is as the mind sees and feels it; the world is as the mind thinks of it” (as qtd. by T.N.Sethumadhavan, 2010). So, our life is in the way we feel and perceive it. Humans are a mixture of emotions and reasons. Reasoning enables them to analyze and judge things with mathematical precision, while emotions help them to understand and empathize others that make them human. Traditionally, people with a high degree of logic and reasoning were believed to be intelligent and. The purpose of the IQ tests was designed to ascertain a person’s intelligence based on the reasoning and the logical aptitude of the person. IQ tests were found to be effective when a person is ‘not’ scared or angry or intrigue about specific things that aroused emotions. Emotions were considered disruptive in nature, which influences the process of thinking of a person (Woodworth, 1940). Mowrer (1960) opined that “emotions are of quite extraordinary importance in the total economy of living organisms and do not deserve being put into opposition with intelligence‟. The emotions are, it seems, themselves a higher order of intelligence.”

Aurora lyrics

Urolithiasis is a common worldwide problem with high recurrence. This review covers thirty-six (36) families starting from alphabet M to R. It includes Rubiaceae (17); Phyllanthaceae and Rutaceae (09); Polygonaceae (08); Pinaceae and Piperaceae (06); Menispermaceae, Myrtaceae, Oleaceae, Oxalidaceae, Plantaginaceae and Ranunculaceae (05); Moraceae and Musaceae (04); Meliaceae, Orchidaceae and Rhamnaceae (03); Moringaceae, Onagraceae, Papaveraceae, Pedaliaceae, and Polygalaceae (02); Magnoliaceae, Malpighiaceae, Molluginaceae, Myoporaceae, Nyctaginaceae, Paeoniaceae, Parmeliaceae, Parnassiaceae, Periplocaceae, Platanaceae, Polypodiaceae, Portulacaceae, Primulaceae and Punicaceae (01) plant used globally in different countries. Hopefully, this review will be helpful for the general public and attract the scientific world for antiurolithiatic drug discovery.

Dr. salman ahmed

Background: Shilajit is a historically valued natural substance with promising but still preliminary scientific support for urinary and diabetic health, yet its growing popularity risks exploitation and exaggerated claims without rigorous human clinical validation. This study investigates the therapeutic effects of Yemeni Shilajit sourced from Dhamar, Ma’rib, and Raymah on hemolytic anemia experimentally induced in rabbits using phenylhydrazine. Methods: Twelve male rabbits were divided into four groups: a control group and three treatment groups, each receiving Shilajit from one of the three regions. Anemia was induced via subcutaneous injection of phenylhydrazine hydrochloride, and treatment was administered orally at a dose of 125 to 250 mg/kg twice daily. Hematological parameters—including packed cell volume (PCV), hemoglobin concentration (Hb), red blood cell (RBC) count, and glucose-6- phosphate dehydrogenase (G-6-PD) activity—were evaluated at various intervals. Results: showed that Shilajit from Dhamar and Raymah significantly increased PCV, Hb, RBC count, and G-6-PD enzyme activity (p < 0.05), suggesting notable anti-anemic effects and potential for restoring hematological parameters to near-normal levels. In contrast, Ma’rib Shilajit exhibited limited efficacy, with significant improvement only in hemoglobin levels. Phytochemical analysis confirmed the presence of essential amino acids and bioactive compounds, such as fulvic acid and dibenzo-α-pyrones, which likely contribute to Shilajit’s therapeutic action. Conclusions: The study concludes that purified Shilajit from Dhamar and Raymah holds promise as a natural remedy for hemolytic anemia, supporting its traditional use and warranting further investigation for pharmacological applications.

Karishma

Background: Malaria in pregnancy (MiP) remains a critical public health concern in Nigeria, with significant implications for maternal and fetal health. Despite national policy guidelines advocating the use of Intermittent Preventive Treatment in pregnancy using Sulphadoxine- Pyrimethamine (IPTp-SP), its uptake remains suboptimal in many rural communities. This study aimed to assess the factors influencing IPTp-SP utilization among pregnant women attending antenatal clinics (ANCs) in rural areas of Abia State. Methods: A descriptive cross-sectional study design was adopted, involving 422 pregnant women selected through a multistage sampling technique across three predominantly rural Local Government Areas (LGAs): Ugwunagbo, Isiala Ngwa South, and Ukwa East. Data were collected using a structured, interviewer-administered questionnaire and analyzed using SPSS version 25. Descriptive statistics, chi-square tests, and Pearson correlation analyses were employed to examine associations between socio-demographic variables, accessibility, beliefs, health system factors, and IPTp uptake. Statistical significance was set at p < 0.05. Results: The majority of respondents were married (82.0%), aged between 25 and 34 years (46.9%), and had attained at least secondary education (71.1%). Key barriers to IPTp uptake included drug unavailability (30.6%), long waiting times (28.9%), fear of side effects (19.4%), and cultural beliefs (23.0%). Notably, only 24.6% reported consistent IPTp-SP availability during ANC visits, and 46.4% had to purchase the drugs outside the clinic. Correlation analysis revealed significant associations between IPTp uptake and distance to clinic (r = -0.412, p = 0.001), health education (r = 0.562, p < 0.001), drug availability (r = 0.489, p = 0.002), and cultural beliefs (r = -0.297, p = 0.012). Chi-square analysis confirmed significant relationships between IPTp uptake and education level (χ² = 19.438, p = 0.001), awareness (χ² = 24.511, p < 0.001), and satisfaction with ANC services (χ² = 14.257, p = 0.003). Conclusion: The study highlights multifaceted determinants affecting IPTp-SP uptake among pregnant women in rural Abia State. These include socio-demographic factors, health system challenges, cultural beliefs, and availability of services. Interventions aimed at increasing awareness, ensuring consistent drug availability, and improving ANC service delivery are critical to enhancing IPTp coverage in rural Nigeria.

Karishma

Systemic onset juvenile idiopathic arthritis (SoJIA) is a rare inflammatory disorder. It is the severest form of juvenile idiopathic arthritis, and complications occur most commonly in this type. Non-responsiveness to standard therapy with corticosteroids and disease-modifying antirheumatic drugs is not uncommon. Interleukin-1 beta (Il-1β) has been shown to be a main contributor to the pathogenesis of SoJIA. Anakinra, a recombinant Il-1β receptor antagonist, was shown to be effective in small cohorts of therapy-resistant adult and pediatric still's patients. This study aimed to evaluate the real-world efficacy, steroid-sparing effect, and safety profile of anakinra in patients with SoJIA at a tertiary care center in Libya. A retrospective case series was conducted on patients with SoJIA treated with anakinra at the Tripoli Children's Hospital between 2010 and 2017. Data on demographic characteristics, disease activity, corticosteroid dosage, concomitant medications, and adverse events were collected at baseline and at 1-, 3-, 6-, and 12-month post-treatment. 13 patients were treated with anakinra with a mean age of 9.4±4.6 years at anakinra initiation and a female-to-male ratio of 2: 1. All patients were on corticosteroids and 92.3% on methotrexate at treatment initiation. The proportion of patients achieving inactive disease (Jadas 10=0) increased over time. A marked steroid-sparing effect was observed: the number of patients requiring high-dose steroids (>0.5 mg/kg/day) decreased from 100% at baseline to 7.6% at 12 months, and 53.8% successfully discontinued corticosteroids entirely. All patients experienced injection site reaction, and macrophage activation syndrome occurred in 15.4% as a side effect after treatment initiation. But no severe infections or fatalities occurred. Reasons for discontinuation included remission (46.1%), drug unavailability (23.0%), inefficacy (15.3%), and side effects (15.3%). Anakinra demonstrated significant efficacy in inducing rapid disease control and reducing corticosteroid dependence in patients with refractory SoJIA, with a manageable safety profile

Mediterranean journal of pharmacy and pharmaceutical sciences

The current study was designed to explore the antiemetic effect of the methanolic extract of Tithonia diversifolia (Hemsl.) A. Gray., leaves using chick emesis model to validate their folk use in G.I. disorders. Emesis was induced by the oral administration of copper sulfate 50mg/kg body weight to male chicks of four days of age. The antiemetic activity was determined by calculating the mean decrease in the number of retching compared to the control. Tithonia diversifolia leaves extract (150 mg/kg orally) showed a significant (p <0.05) antiemetic effect and was compared with the reference drug chlorpromazine.

Dr. salman ahmed

Subcutaneous emphysema is defined as a trapped air in tissues under the skin. This entity most often occurs in the chest wall and neck but can infrequently happen in other parts of the body like the orbital area [1]. The main mechanism of subcutaneous emphysema is the traumatic damage of the anatomical air-filled cavities or canals. Most of the rare, reported cases of orbital and periorbital emphysema were described in adults as complications of several types of traumas, including direct trauma, recent or previous surgery [2,3], barotrauma secondary to non-invasive ventilation, such as continuous positive airway pressure therapy [4], and even post forceful noseblowing [5]. In this report, we described the first reported case of post-vomiting subcutaneous emphysema surrounding the medial canthus of the right eye in a 10-year-old boy.

Karishma

Schizophrenia is treated with antipsychotic drugs and is a chronic neuropsychiatric disorders. The influence of antipsychotics on the cytokine systems may be responsible for their clinical efficacy in schizophrenia. Granulocytopenia and agranulocytosis are severe side effects of antipsychotic therapy. The objective of this study was to estimate incidence of drug-associated agranulocytosis in newly diagnosed schizophrenic patients in and to evaluate the risk factors and outcomes. Seven participants groups were designed. Healthy persons as control. Schizophrenic patients before treatment. Schizophrenic patients after one-month of treatment. Schizophrenic patients after two - month of treatment. Schizophrenic patients after three - month of treatment. Schizophrenic patients after chronic treatments. Schizophrenic patients one month after chronic treatment. This study included screening for the expression and function of circulating leukocyte granulocyte-macrophage colony-stimulating factor receptor, screening of patient's biochemistry and haematology picture. Granulocyte-macrophage colony-stimulating factor expression was decreased after antipsychotic treatment for one month and continued to decrease after two months' treatment. Granulocyte-macrophage colony-stimulating factor expression starts to increase after the two-month treatment and continues increasing to controls or newly diagnosed schizophrenics or after chronic treatment. Complete blood counts were not changed compared. Liver function showed a transient increase in serum alkaline phosphatase after one and two month of treatment. All other parameters were not changed. Kidney function showed that urea and creatinine levels were within the normal range during the different treatments. Concerning lipid profile, low density lipoproteins levels were increased after one month, two months of treatment and after chronic administration of the antipsychotic drugs. It is concluded that antipsychotic treatment produces a decrease in granulocyte-macrophage colony-stimulating factor expression; the decrease reach the maximum effect after two months, then starts to increase back to normal levels. A transient increase in serum alkaline phosphatase in the first two months' treatment. Urea and creatinine levels and lipid profile were within normal range, except low density lipoproteins levels were increased during the two months treatment and after chronic administration of the antipsychotic drugs.

Mediterranean journal of pharmacy and pharmaceutical sciences

In this work a set of some cyclic peroxy ketals were tested for their antimalarial activities. Quantitative structure activity relationship (QSAR) analysis was applied to 20 organic compounds of the above mentioned derivatives using Physicochemical, informational and 2D-autocorelation parameters and modeled their antimalarial activity (logIC 50) values. The multiple regression analysis clearly indicates that 5 BIC, 1 IC, MATS4v and ST parameters yielded the best model having R 2 value of 0.9515. The predictive powers of the models were explained using LOO (Leave-One-Out) Cross validation procedure. The results are also discussed on the basis of ridge regression.

Dr. shweta sharma

The main focus of this study is the coverage of New Straits Times (NST) of the first Palestinian General Elections for two presidential candidates namely, Yasser Arafat and Samiha Khalil. This study aimed to explore if any of Entman’s 1993 framing functions was used in the coverage of this issue and to explore whether the tone of NST coverage was negative, positive, balanced or neutral. To achieve the aims of this study, qualitative content analysis of elections stories from NST has been adopted. The number of news stories was eight, and the time frame started from 19th January to 13th February 1996, where three of these stories were published on the same day of 22nd January, two days after holding the elections on 20th January. Defining problems and diagnosing causes were the most prominent of Entman’s four framing functions presented in all the articles. The moral judgment function was included in four news stories, and suggesting remedies was included in two news stories out of eight. The findings revealed that Yasser Arafat received 50% balanced coverage, followed by 37.5% positive coverage, and only 12.5% negative coverage, while Samiha Khalil received 67% balanced coverage, compared to 33% positive coverage.

Mohammed fadel arandas

The primary cause of many fatalities is hypertension (high blood pressure). Many hypertensive patients are not even aware that they have the condition. As a result, hypertension is sometimes referred to as a silent killer. Until the harmful effects of high blood pressure, such as myocardial infarction, stroke, renal abnormalities, and vision problems, are identified, hypertension is typically asymptomatic. Without the use of herbs and dietary control, conventional medication therapy could not be enough to treat hypertension. The growing number of persons with high blood pressure can be effectively treated using alternative medicine. Numerous alternative therapies, such as diet, exercise, stress management, vitamins, and herbs, have been proven to be effective in lowering high blood pressure. There are several medications available to treat this disorder however popular antihypertensive medications typically have a long list of adverse effects. Numerous active ingredients with pharmacological and preventative qualities found in medicinal plants can be used to treat hypertension. This review discusses an overview of important medicinal plants and phytochemicals with hypotensive or antihypertensive effects.

Mediterranean journal of pharmacy and pharmaceutical sciences

Action research is such a process by which B.Ed. pupil teacher attempt to study their problems scientifically in order to guide, correct and evaluate their decision andaction There are two important components of action research:(1) the consumer are the researches and (2) the research take place where there is a felt need of a solutionof a problem and when the results can be put in practice.The steps in action research are – identification of a problem area, the selection of a specific problem and the formulation of a hypothesis, the accumulation of evidence,the inference from this evidence and the continuous retesting.The importance of action research that its lies in the fact that this helps in finding quick solutions of immediate problems which search by b.ed. Students , administratorand teacher. Action research is a way to find problems and their solution S.M. Corey has developed this research technique. Objectives of action research are – processin school practice, progress of a teacher, improvement or curriculum, increase in knowledge of administrator or inspector. Need, interest, discipline, social problems,learning problem, curriculum and teachers are the field of action research. There are various steps of action research such as specific problem .Causes, hypotheses,experiment and conclusion. Outline the action research is also mentioned. Action research has been proven most beneficial in the field of diagnostic education

Kamal singh

Scheduling is the need of every project. Without scheduling, projects don’t fulfill time constraints, go over spending plan. It is a process utilized by teams to organize and structure their resources so the tasks they need to complete are scheduled based on availability and capability. This process is more beneficial if it is required to allocate and assign task to the resources without allocating their schedules. This paper reviews different types of network scheduling techniques, which are used to schedule a task. These techniques are very effective and help us to preplan the whole scheduling process

Vartika agarwal

The objective of this research was to investigate the effect of initial chick weight at the first day of the hatch on subsequent performance of Iraqi local chickens. 150 unsexed chicks of local chickens weighted at first day of hatch then divided to five groups (A, B, C, D, E) according to the initial weight (26.4, 31.89, 36.38, 41.09, 46.91) gm, the birds were reared in a wooden cage consist of individual compartments with dimensions (30×30×40) cm, The feed and water was available adlibitum, The birds and feed weighted weekly by sensitive balance. The result shows that initial weight had a significant effect on body weight, weight gain, feed and protein consumption, and growth rate but not significant on feed and protein conversion, where group E showed the best results, The relationship between initial body weight and productive traits were studied and the prediction equation of productive traits depending on initial weight shows highly significant

Rafea mohammedtaher khulel

Background: Dyslipidemia is an established cardiovascular risk factor in persons with type 2 diabetes (T2D), yet the extent to which these conditions co-occur in Africa is unknown. This systematic review and meta-analysis aimed to determine the prevalence of dyslipidemia among persons with T2D in Africa. Methods: Medline, Embase, Global Health, Scopus, and Web of Science were searched on 5 December 2023. This review adhered to the PRISMA guidelines and was prospectively registered on PROSPERO. The prevalence data for dyslipidemia was pooled through a random-effects meta-analysis. The authors assessed heterogeneity and publication bias using I2 statistics and Egger’s test, respectively. Results: Our search identified 8035 records, of which 60 articles involving 20 034 individuals with T2D were included in this review. The pooled prevalence of dyslipidemia recorded 38.6% (95% CI: 34.1–43.4) for high TC (≥ 5.2 mmol/l), 52.7% (95% CI: 44.2–61.1) for high low-density lipoprotein cholesterol (LDL-C) (≥ 2.6 mmol/l), 43.5% (95% CI: 37.1–50.0) for low high-density lipoprotein cholesterol (HDL-C) (< 1.0 mmol/l in men and less than 1.3 mmol/l in women), and 37.4% (95% CI: 32.2–42.9) for high triglycerides (TG) (≥ 1.7 mmol/l). Subgroup analysis based on gender indicated a notably higher prevalence of dyslipidemia among females compared to males. Conclusion: Dyslipidemia is prevalent among persons with T2D in Africa. This highlights the need for early screening, diagnosis, and management of dyslipidemia to mitigate the risk of cardiovascular complications in this population.

Emmanuel ekpor