The kidney stones are one of the most widely spreading disorders in the world. The present study was undertaken to evaluate the efficacy of ethanolic extract of Didymocarpuspedicellata and Ashwagandha for its antiurolithiatic activity in rats. Urolithiasis was induced in adult male albino wistar rats by 0.75% of ethylene glycol for 28 days. The effect of the oral administration of the ethanolicextracts has been studied and is compared with the effect of oral administration of Cystone(Himalaya) as a standard on Wistar rat. Ethylene glycol feeding resulted in hyperoxaluria as well as increased renal excretion of calciumand phosphate. Supplementation with ethanolic extract of the plants significantly reduced the elevated urinary oxalate, showing a regulatory action on endogenous oxalate synthesis. Both the plant extract showed significant antiurolithiatic activity

Zeenath banu

Network on a chip is a concept in which a single silicon chip is used to implement the com-munication features of large-scale to very large-scale integration systems. For high-end System on Chip de-signs, Network on Chip is considered the best integrated solution. NoC has several advantages over dedicat-ed wiring and buses i.e. increased bandwidth, low latency, less power consumption and scalability. Reduc-tion in the latency (end-to-end latency and network latency), loss probability, energy consumption and re-sponse time are the basic parameters which are considered by the researchers for the optimization of the networks-on-chip topologies. In this paper we review the most popular technologies and also some recent topologies for interconnection networks. We study their performance and summarize their strengths & weakness.

Ashish mulajkar

Many people are distracted from the normal lifestyle, because of the hearing loss they have. Most of them do not use the hearing aids due to various discomforts in wearing them. The main and the foremost problem available in it is; the device introduces unpleasant whistling sounds, caused by the changing environmental noise, which is faced by the user daily. This paper describes the development of an algorithm, which focuses on the adaptive feedback cancellation, that improves the listening effort of the user. The genetic algorithm is one of the computational techniques, that is used in enhancing the above features. The performance can also be compared with other comprehensive analysis methods, to evaluate its standards.

Jayanthi g

Newborn or neonate denotes to an infant in the first few days after birth. They are not small children when it comes to medicinal use and formulation development. Neonates include term, post-term and preterm babies. The neonatal period for preterm newborn infants is defined as the day of birth through to the expected date of delivery plus 27 days. The majority of drugs used in sick newborns receiving intensive care are unlicensed and off-label, exposing infants to a greater risk of adverse drug reactions (ADRs). This study is extremely important due to the presence of a variety of drug information sources if used together lead to medication errors. From this point of view, this approach is suggested to eliminate or minimize these varieties. Where the most important challenges in neonatal intensive care unit (NICU) is proper and correct calculations and administration. Drug-related events in a hospital setting are the highest cause of recorded errors such as in the USA and UK

Mediterranean journal of pharmacy and pharmaceutical sciences

Diabetes is a global issue, the diabetes epidemic is expected to continue, and the burden of diabetes causes catastrophic expenditure for healthcare system. The current study aimed to determine the presentation, the clinical feature and cardio-vascular risk factors in patients with diabetes. A retrospective observational study had been conducted in out-patients department at Almustaqpal Almosherq Centre during September, 2013 till September, 2020, the total number of attended out-patients department were 1 024, 820 patients who were selected for this study. A special perform was completed for every patient, which included details about patient’s demographics, points in clinical history, relevant investigations and clinical examinations were recorded. The study reported that out of 820 patients, 66% (n = 538) was female and their age range was between 14 - 87 years with a mean age of 56.53 ± 13.49 years, 96% (n = 791) were clinically diagnosed as type II diabetes, 07% of the patients were diagnosed as pre-diabetes, the duration of diabetes ranged from newly diagnosed to more than 10 years, with 46% (n = 379) of the studied population were more than 10 years diabetes duration, 70% (581) were presented with classical symptoms of diabetes. Initial treatment for diabetes also different in the studied sample, were absent of anti-diabetic medications in 30% (n = 248) of the patients, they refused to start glucose lowering drugs, 34.6% (n = 284) of them have morbid obesity (body mass index is more than 40), 80% (n = 662) have high HBA1c (more than 8 g%), 40.3% (n = 240/596) were uncontrolled hypertension on anti-hypertension drugs, 95.6% (n = 682/713) were controlled on treatment of lipid lowering drugs. This study showing the presentation of diabetes were the common, type II diabetes, at age group between 41 - 66 years about 65%, female sex, with high body mass index, high glycated hemglobulin and uncontrolled hypertension. There is concern that diabetic patients were occurring at a high frequency in younger adults, where longer duration of illness could increase the risk of developing more complications in later life. The rate of coexist cardiovascular risk factors (hypertension, dyslipidaemia and obesity) in Libyan patients with diabetes is highlighted.

Mediterranean journal of pharmacy and pharmaceutical sciences

Social bots are computer programs created for automating general human activities like the generation of messages. The rise of bots in social network platforms has led to malicious activities such as content pollution like spammers or malware dissemination of misinformation. Most of the researchers focused on detecting bot accounts in social media platforms to avoid the damages done to the opinions of users. In this work, n-gram based approach is proposed for a bot or human detection. The content-based features of character n-grams and word n-grams are used. The character and word n-grams are successfully proved in various authorship analysis tasks to improve accuracy. A huge number of n-grams is identified after applying different pre-processing techniques. The high dimensionality of features is reduced by using a feature selection technique of the Relevant Discrimination Criterion. The text is represented as vectors by using a reduced set of features. Different term weight measures are used in the experiment to compute the weight of n-grams features in the document vector representation. Two classification algorithms, Support Vector Machine, and Random Forest are used to train the model using document vectors. The proposed approach was applied to the dataset provided in PAN 2019 competition bot detection task. The Random Forest classifier obtained the best accuracy of 0.9456 for bot/human detection.

Chandra sekhar sanaboina

Salinity is a major environmental stress which has been studied extensively and has its impact on agriculture in the past, present and future. The global importance of salt affected soils can be explained by their wide distribution on all continents covering about 10% of the total land surface. At present, there are nearly 954 million ha of saline soils on earth’s surface. It is extremely difficult to quantify the social and economic costs of salt prone land and water resources. Plant Growth Promoting Rhizobacteria (PGPR) is a group of bacteria that actively colonize plant roots and increase plant growth and yield. They play an important role within the interaction between soil and plant. As plants grow on marginal soils such as saline soils, the importance of the rhizobacteria increases as they mobilize nutrients and provide tolerance ability to the plants. In the present study, an attempt was made and isolated 51 PGPR isolates (Phosphate Solubilizing Bacteria–18; Azotobacter spp.-16 and Azospirillum spp.-17) from different salt affected areas in Tamil Nadu and Puducherry. All the isolates were screened for their efficacy against different sodium salts namely sodium chloride, sodium citrate and sodium sulphate. It was observed that the absorbance of the culture broth grown in salt stress to sodium chloride decreased with increasing concentration of the salt. Similarly decrease in growth pattern in terms of the absorbance was also observed in salt stress to sodium citrate and sodium sulphate.

Dr. saranya devi k

This research will discuss the new destination of Toraja coffee as a tourism development strategy. Questions that will be answered is what is the attraction of Toraja coffee tourism as a new tourist destination. Methods of research conducted are field observation and interviews with coffee stakeholders as an informant and foreign tourists as respondents. The results of this study concluded that the appeal of Toraja coffee as a tourism destination is Toraja coffee has characteristic (taste) differently based on the planting area Toraja coffee. There are 15 names of coffee products based on the region and the name of Toraja coffee products taken from the region. E.g. coffee Toraja Sapan, derived from the Sapan area, and coffee Sesean derived from the village of Sesean. Perception of foreign tourists to Toraja coffee is that the taste of Toraja coffee is different based on the height of the coffee planting area to be a tourism identity Toraja Agritourism.

Muhammad hasyim

Background: Pregnancy-related hormonal changes increase the risk of gingival inflammation and bleeding. Poor oral hygiene and dietary habits, such as frequent intake of sugary foods, may worsen this risk. Understanding the relationship between diet, oral hygiene, and gingival health in pregnant women is essential for improving prenatal care. This study aimed to assess dietary patterns, oral hygiene practices, and self-reported gingival bleeding among pregnant women attending the Mother and Child Hospital, Ondo, Nigeria. Methods: A descriptive cross-sectional study was conducted over four months among 216 pregnant women at the Mother & Child Clinic, University of Medical Sciences Teaching Hospital, Ondo, Southwest Nigeria. A structured, self-administered questionnaire collected data on sociodemographic characteristics, oral hygiene habits, perceived oral health conditions, and dietary patterns. Clinical oral examinations were conducted using the Oral Hygiene Index. Data were analyzed using SPSS version 25, with p < 0.05 considered significant. Results: Most participants (79.2%) were in their second or third trimester. Although 83.3% used toothbrushes and 52.3% brushed twice daily, 39.8% had poor oral hygiene, and 33.3% reported gingival bleeding. Despite 76.4% awareness of dental services, 53.2% had never visited a dentist. Most participants frequently consumed fruits (88.9%), vegetables (84.8%), and animal proteins (84.7%), while 43.0% consumed sugary drinks regularly. No significant association was found between dietary habits and gingival bleeding. Conclusion: The study revealed a clear awareness–behavior gap: good knowledge of oral health did not translate into optimal hygiene practices or dental visits. Poor oral hygiene remained common, and gingival bleeding was prevalent. Although most participants had healthy diets, sugary drink intake was still high. Diet alone was not protective against gingival bleeding. Promoting effective oral hygiene and integrating dental care into prenatal programs is recommended.

Karishma

Identifying the targets for improving antimicrobial prescription and development of antimicrobial stewardship interventions can better serve to combat the situation of antimicrobial resistance. The primary objective was to determine the prevalence of antimicrobial use at tertiary care teaching hospital with both acute and long-term care patients. A periodical point prevalence survey was done in a tertiary care hospital of South India during 2019 using manual and webbased GLOBAL-PPS tool. Of 945 patients eligible for the study, 645 (69.5 %) received at least one antibiotic, with highest rates in the adult surgical ward and pediatrics. Of 645 therapeutic antibiotic prescriptions, 58.6% prescriptions have an infectious indication of them, 62.6% are community-acquired infections. Third-generation cephalosporins were the most prescribed antibiotics. The prevalence of antibiotic use is very high, and our study evidence that the country needs a robust antimicrobial stewardship intervention program.

Vineela chadalavada

“Phyllanthus emblica” known to be amla has role in the skin aging influences the changes in skin, including skin dryness, wrinkle, and irregular pigmentation. Initially the 6 day observation has been taken for the ageing activity to be track to study the TREM2 pathway of “Phyllanthus emblica”. Cellular observation and pathway consideration: The environmental impact of pH, Temperature, Humidity and stability of amla fruits is important for the ageing of cells in neuronal cascade of TREM2 Pathway, while studying the fruits cell cycle. The melanin suppression through inhibition of tyrosinase and tyrosinase-related protein-2 activities, the strong antioxidant, and the potent matrix metalloproteinase-2 in cellular observation of tyrosinase pathway. The study aimed to evaluate the anti-skin aging efficacy of amla.

Wahul umesh

Background: Cannabis sativa has garnered significant attention due to its complex phytochemistry and diverse pharmacological properties. Given the rising interest in medicinal cannabis, understanding its physicochemical properties is crucial for drug development, quality control, and abuse prevention. This study aimed to analyze its phytoconstituents, with a focus on the isolation and profiling of cannabinoids. Methods: Fresh C. sativa leaves were macerated in ethanol to obtain a crude extract, which underwent phytochemical screening to detect alkaloids, flavonoids, cardiac glycosides, terpenes, steroids, and resins. Thin-layer chromatography (TLC) was performed using a n-hexane/diethyl ether (8:2) ratio as the mobile phase to separate cannabinoids, with visualization under UV light. Column chromatography further purified the extract, and subsequent TLC confirmed cannabinoid-rich fractions. Hydrogen peroxide-modified TLC was employed to assess oxidation effects on cannabinoid stability. Results: Phytochemical screening confirmed the presence of alkaloids, flavonoids, terpenes, and resins, while saponins and tannins were absent. TLC analysis revealed distinct Rf values for tetrahydrocannabinol (THC = 0.94) and cannabidiol (CBD = 0.90), with color differentiation indicating successful separation and a more polar nature of CBD. Column chromatography yielded enriched fractions, validated by TLC. Hydrogen peroxide exposure altered Rf values of 0.78 to 0.8, suggesting oxidative degradation. The study identified THC and CBD as dominant markers, alongside minor cannabinoids, reinforcing C. sativa’s complex chemical profile. These findings give clues to further research into standardized extraction protocols and stability testing to optimize medicinal applications of the plant and its phytoconstituents. Conclusions: This study highlights the efficacy of TLC and column chromatography for cannabinoid isolation and profiling. The presence of THC, CBD, and other bioactive compounds underscores C. sativa’s dual therapeutic and psychoactive potential.

Karishma

Recently, the definition of cardiorenal syndrome (CRS), a condition with a complicated pathogenesis, has been revised. Logically, CRS syndrome should be classified according to the initial organ that is injured, resulting in damage to another organ. Hence, there are only three main categories of CRS. Category one includes acute and chronic CRS. Category two involves renal-cardiac syndrome (RCS), which can be classified as acute or chronic. The third category represents secondary CRS, referred to as cardio-reno-cardiac syndrome (CRCS), which can be subdivided into acute and chronic CRCS. In this part of our series, we will discuss the epidemiology, pathophysiology, diagnosis, treatment, and prevention of acute CRS. We retrieved articles published on acute CRS using different keywords and phrases between January 2019 and June 2025 to achieve these goals.

Karishma

India is a diverse land with a population of approximately 1.3 billion,1 placing India at the second position in the world in terms of population. Among these, Seventh-day Adventists' existence, as per the statistics of 2019, is 1.14 million.2 India is a richly diverse community, inclosing a diverse range of ethnic groups, each, not just different, but on occasion quite the opposite.

Santosh kumar

To satisfy user expectations and resource needs, academic libraries are realizing more and more how important it is to integrate innovative technologies. Effective use of technology is essential to educational libraries' success. A thorough analysis finds new trends that university libraries are using to satisfy present demands. In the twenty-first century, libraries are becoming dynamic establishments that meet the changing demands of society. These consist of data literacy, digitization, and the incorporation of augmented and virtual reality technologies. Additionally, libraries are becoming community hubs for educational programs like seminars and lectures. Libraries are helping people navigate the immense ocean of information, and data literacy along with knowledge skills is essential. Services driven by AI are improving client experiences and expediting procedures. With libraries implementing eco-friendly architectural designs & community engagement tactics, sustainability projects are becoming more and more well-known. Libraries are responding to these shifts by creating creative solutions, including collaborations, environmental initiatives, and AI integration, all while overcoming financial limitations. To remain relevant, they are adopting cutting-edge strategies like AI-powered services, collaborations, sustainability, virtual and alternative reality technologies, open data initiatives, maker spaces, & creative labs. Libraries are implementing cutting-edge solutions to address a variety of community needs and encourage lifelong learning, despite obstacles such as limited financing, evolving librarian roles, privacy and security concerns, and adjusting to changing societal standards.

Dr. awadhesh singh gautam

Production process in the manufacturing industries has proven wasteful of the resources in the production process over time. integrating of lean principles in the manufacturing activities has brought notable success in a complex and slow production process in an industry. This study aims at integrating of lean principles to a product development process to eliminate break down cases as it makes the process easy as well as speeding up the product development in an automotive industry. Three major phases are applied in product development namely; the early concept phase, middle core design and the launch phase. An exceptional definition of products development of lean principles are applied to come up with an analysis framework. Through interviews, observations, documentation and experience barriers that causes large number of wastes can be established. Lean principles will then be applied to eliminate such causes in the product development and then derive conclusion that shows the industry the process of lean in product development in the entire process

Levi p. cheworei

Globally, approximately 12% of the population is inflicted by various types of urolithiasis. Standard treatments are available to avert and treat urolithiasis, but with significant adverse side effects. Pentacyclic triterpenes represent a group of naturally occurring compounds with immense potential as treatments for kidney stones. This review aims to provide an integrative description of how pentacyclic triterpenes can effectively treat calcium oxalate urolithiasis through various antioxidant, anti-inflammatory, diuretic, and angiotensin-converting enzyme inhibition mechanisms. Some pentacylic triterpenes showing promising activities include lupeol, oleanolic acid, betulin, and taraxasterol. Moreover, future perspectives on developing pentacyclic triterpenes in formulations/drugs for urinary stone prevention are highlighted. It is anticipated that compiled information would serve as a scientific baseline to advocate further investigations on the potential of pentacyclic triterpenes in urolithiasis remediation.

Dr. salman ahmed

Therapeutic nucleic acids demand specificity and accuracy in design as well as delivery strategies used in replacement or silencing of the target gene. Gene therapy is believed to be the therapy in which the root cause of the diseases can be treated at the molecular level. Generally gene therapy helps in the identification of the origin of the disorder instead of using drugs to diminish or control the symptoms. The application of nucleic acids to treat and control diseases is known as “gene therapy.” Gene therapy consists on the substitution or addition of a functional gene into the nucleus of a living cell, in order to treat a disease or repair a dysfunction, caused by this gene failure. This therapy is used to correct defective genes, which are responsible for genetic diseases. Thus, gene therapy can be used to prevent, treat or regulate hereditary or acquired disorders, by the production of therapeutic proteins. The gene therapy is mediated by the use of viral and non-viral vectors to transport foreign genes into somatic cells to restorative defective genes. This review focuses on viral vectors in detail.

Dr.p.v.kamala kumari

The utilization of traditional medicine (TM) is prevalent among the general population in Africa; however, its use among individuals with diabetes in the region remains underdocumented. This review aimed to synthesize the available literature to identify the prevalence and predictors of TM use among persons with diabetes in Africa. A systematic search was conducted across multiple databases, including MEDLINE, Embase, CINAHL, and AMED, covering studies published from 2000 to April 2023. Of 1560 records identified, 24 articles met the inclusion criteria. The prevalence of TM use varied significantly, ranging from 12.4% to 77.1%, with a median prevalence of 50%. TM was commonly used concurrently with conventional medicine (CM) (35.4–88.4%), with a majority (63.8–91.3%) not disclosing TM use to healthcare providers. Female gender, long diabetes duration, use of oral antiglycaemic medication and family history of diabetes emerged as the most common factors that predicted the use of TM. This review highlights the widespread use of TM among individuals with diabetes in Africa, often in conjunction with CM. The high prevalence of undisclosed TM use emphasizes the urgent need for healthcare providers to actively inquire about TM use during clinical consultations to address potential herb–drug interactions and adverse effects.

Emmanuel ekpor

The result of this study showed that the growth performance of the two varieties of amaranth were greatly reduced, in terms of number of leaves per plant in the saline treated plant exposed to the highest saline concentration compared to the control. Amaranthus cruentus had more number of leaves (6.63) than Amaranthus hybridus (5.67) and Amaranthus hybridus had higher survival rate than Amranthus cruentus(1.83). Although both test plant varieties responded to varying saline concentrations in various ways, both tends to show similar responds. Also, the number of days to germination increases with increased salinity concentrations the two amaranth varieties was both adversely affected by higher saline concentrations, where increased salinity concentrations caused reduction in shoot length Also, the leave breadth was better in the control and the plants with lower amounts of NaCl concentration(0.025 and 0.05), this implies that Amaranthus hybridus and Amaranthus cruenthus tolerate moderate salinity levels, while the plants with higher salinity concentrations (0.075,0.01,0.15) had leave breadth that were small, and eventually died because of high amounts of salt.

Barka peter