Emesis, also known as nausea and vomiting, are common symptoms associated with ingestion of toxicants, drug side effects, advanced terminal diseases such as cancer and postoperative procedures. Emesis is mediated through the coordinated action of central and peripheral regulatory centres that involve receptors including dopamine Type 2, serotonin, muscarinic cholinergic, histamine, cannabinoids and NK-1 receptors. Many anti-emetic drugs targeting these receptors are currently in use, but they also cause undesirable side effects such as excessive sedation, hypotension, dry mouth, dysphoria, hallucinations and extrapyramidal signs. This review highlights the pharmacological mechanism of emesis, current antiemetic drugs, and a detailed analysis of in vitro and in vivo anti-emetic bioassay models. The pharmacology of crude natural products extracts and purified anti-emetic compounds (cannabinoids, chalcones, diarylheptanoids, flavonoids, hydroxycinnamic acids, lignans, phenylpropanoids, polysaccharides, saponins, terpenes and glycosidic derivatives) are also systematically presented with their mechanism of action. The potential of natural products as sources of new clinically proven anti-emetic drugs is discussed.

Dr. salman ahmed

The free senior high school policy is one of the best social and economic intervention policies that openly affect both parents and their wards in senior high school. This realisation is reached on the backdrop of the policy’s role in redeeming parents from their economic and financial burden. This study, therefore, looks at the effect of introducing the free senior high school policy on the economic and social lives of parents and students respectively. A correlational cross-sectional descriptive design was used. Questionnaires were administered to three hundred and thirty-six (336) parents of wards in three senior high schools in the North East and Upper East Regions of Ghana. The study confirms that the introduction of the free senior high school policy relieved the financial burden of parents, especially guardians from rural settlements. Besides, there was a lack of adequate stakeholder consultation, hence saddled with implementation challenges. Delay in disbursement of funds for feeding and learning materials presented yet another problem. It is important that governments find sustainable sources of funding for the educational system and also ensure the double-track system is regularised into a single-track system by expanding academic user facilities and increasing the numerical strength of both teaching and non-teaching staff in various senior high schools.

Juabin matey

e purpose of the study is to investigate the impact of leadership style on employee job satisfaction in five-star hotels. A questionnaire consisted of 57 items based on five-point likert scale (from strongly disagree to strongly agree) was used to measure both leadership style and job satisfaction from employees’ perspectives. Using random sampling, the researcher distributed 350 questionnaires, 220 of which were completed. The obtained data from the questionnaires are investigated through the SPSS statistical packaged software. The empirical results indicated that two types of leadership styles, namely, democratic and laissezfaire were found to have direct positive significant relationships with employees’ job satisfaction. The findings showed that the dominant leadership style was democratic and employees were moderately satisfied with their job. This implies that democratic leadership is deemed suitable for managing hotels. The study’s results show that different leadership style will have different impacts on employee job satisfaction. An interesting finding is that democratic leadership has a stronger influence on job satisfaction than laissez-faire leadership does. As a result, by adopting the appropriate leadership styles, leaders can affect employee job satisfaction.

Mukhles m. al-ababneh

Currently, vehicle to vehicle communication is an important application and thrust area of research. In this paper the author highlighted the workings, executions, implementations and the application of the Internet of Things (IoT) in transport management and vehicle to vehicle communication systems. The main advantage of this Industry 4.0 based IoT technology is that it helps us to reduce road traffic and accidents. The limitations of GPS like accuracy, precision, effective analysis, etc. has led to the evolution of Mobile based V2V communication which is more effective, error proof, result oriented and smart. For proper analysis of traffic vehicle to vehicle communication is established. Random Data from vehicles taken by numerous sensors. Any car coming in its variety could effortlessly share the data by either of two cars nearby. With the help of vehicle to vehicle communication we can provide a path of emergency vehicles to reach the destination quickly. Based on the V2V application, Red and Green signals can be marked on the path as per traffic density and the emergency vehicle can take the shortest, fastest and low density route. Similar such examples are elaborated in the current research manuscript that will help the researcher in effectively finding the research gap for further advancement, analysis, innovation and optimization.

Vartika agarwal

Vigna aconitifolia (Jacq.) Marechal. (Papilionaceae) is a medicinally important plant used for treating different diseases, especially dermatological disorders. Alkaloids, phenols, flavonoids, and phytic acid have been reported in this plant. Vigna aconitifolia also exhibits antioxidant, antidiabetic, and hypocholesterolemic activities. The present review attempts to compile all the previous data based on its medicinal uses, phytochemistry and pharmacology reported in the earlier articles.

Dr. salman ahmed

This study was carried out to evaluate the effects of thermal processing techniques on the nutrient and antinutrient contents of pigeon pea (Cajanus cajan) flours. The pigeon pea seeds were sorted, cleaned and divided into five equal lots of 0.5kg each. Four lots of pigeon pea seeds were processed into blanched, boiled, roasted, and autoclaved pigeon pea flours, while the fifth lot was processed raw and used as control. The raw and thermally processed samples obtained were analysed for nutrient and antinutrient composition using standard methods. The proximate composition of the samples showed that the flours had a range of 8.61 - 11.46 % moisture, 21.13 - 23.94 % crude protein, 1.26 - 1.68 % fat, 5.12 – 6.10 % crude fibre, 1.74 – 2.97 % ash, 55.56 – 60.41 % carbohydrate and 333.45 - 342.75 kJ/100g energy, respectively. The mineral composition showed that the flours contained 86.24 – 144.72 mg/100g calcium, 137.80 – 170.33 mg/100g magnesium, 125.86 - 156.76 mg/100g potassium, 66.66 – 95.62 mg/100g sodium, 4.38 – 6.64 mg/100g iron and 130.27 – 178.29 mg/100g phosphorus, respectively. The vitamin content of the flours were 3.09 - 4.33 mg/100g ascorbic acid, 0.05 - 0.17 mg/100g thiamine, 0.03 - 0.21 mg/100g riboflavin, 0.13 - 0.28 mg/100g niacin, 3.21 - 6.25 mg/100g vitamin A and 1.10 - 2.70 mg/100g vitamin E, respectively. The antinutrient composition of the flours also showed that the levels of trypsin inhibitor, tannin, phytate, oxalate, saponin and haemagglutinin ranged from, 2.30 – 5.61 Tiu/mg, 0.81 – 1.5mg/100g, 1.12 - 4.18mg/100g, 0.48-4.01 mg/100g, 1.28 – 3.66 mg/100g and 1.30 – 7.44 Hiu/g, respectively. Therefore, the study showed that thermally processed pigeon pea flours could be used as nutrient dense ingredients in the preparation of a wide range of foods for children, adolescents and aged adults especially in developing countries where the problems of protein-energy malnutrition and micronutrients deficiencies are prevalent than the raw sample.

Okechukwu obed chukwuemeka

Standardization of crude drugs is a code of conduct and an essential need of the time. Substitution and adulteration now become a widespread practice, which makes the global crude drug market unsafe for crude drugs depending on the world population. Moreover, crude drug evaluation is not easy because numerous influential factors affect the bio-efficacy and reproducibility of therapeutic effects. The broad spectrum of standardization ensures the correct substance in the proper amount for desired therapeutic effects. It also provides all possible careful measures taken from collection and manufacturing to drug dispensing for clinical application. The authors have tried to cover precise tools for crude drug standardization in the present review.

Dr. salman ahmed

The seeds for this work were planted many years ago when Linda Bean wastranscribing some of my lectures and encouraged me to write a book. Shepatiently labored through years of archived material until it was time for me tobegin writing. Her commitment and dedication to this project are deeplyappreciated.Once I began writing, Karen Entner assisted me by organizing materials,making content suggestions, and maintaining the manuscript. We workedtogether to edit version after version until the flow of words brought a sense ofpeace to the heart, mind, and soul. Her dedication and heartfelt work are muchappreciated and one of her lifelong dreams comes to fruition with the publicationof this book. “This above all: to thine own self be true, and it must follow,as the night the day, thou canst not then be false to any man.” —William ShakespeareShakespeare’s age-honored words, spoken by Polonius to his son Laertes in ActI of Hamlet, sound so clear and unambiguous. They tell us that to maintainhonest relations with others we must first be true to ourselves. Yet if Laerteswere to be totally honest with himself, he would realize that his father may aswell have told him to catch the wind. After all, to which “self” are we to be true?Is it the one that shows up when we’re in a bad mood, or the one that is presentwhen we feel humbled by our mistakes? Is it the one who speaks from the darkrecesses of the heart when we’re depressed or upset, or the one that appearsduring those fleeting moments when life seems so fanciful and light?From these questions we see that the concept of “self” may turn out to be abit more elusive than initially presumed. Perhaps if Laertes could have turned totraditional psychology, it would have shed some light on the subject. Freud(1927), the father of psychology, divided the psyche into three parts: the id, theego, and the superego. He saw the id as our primal, animal nature; the superegoas the judgment system that society has instilled within us; and the ego as ourrepresentative to the outside world that struggles to maintain a balance betweenthe other two powerful forces. But this certainly would not have helped youngLaertes. After all, to which of these conflicting forces are we to be true?Again we see that things are not always as simple as they seem. If we dare tolook past the surface of the term “self,” questions arise that many people wouldrather not ask: “Are the many aspects of my being all equally part of my ‘self,’or is there only one of me—and if so, which, where, how, and why?”In the following chapters, we will undertake a journey of exploration of“self.” But we will not do so in a traditional manner. We will neither call uponthe experts in psychology, nor upon the great philosophers. We will not argueand choose between time-honored religious views, or resort to statisticallysupported surveys of people’s opinions. We will, instead, turn to a single sourcethat has phenomenal direct knowledge on the subject. We will turn to one expertwho, for every moment of every day of their life, has been collecting the datanecessary to finally put this great inquiry to rest. And that expert is you.

Kamal singh

Aerva lanata species belonging to Amaranthaceae family (a.k.a mountain knot grass/Gorakha Ganga is a perennial shrub. It is self-pollinating, bisexual plant having globose like structure has various phytochemical constituents. Among the 28 species of Aerva, medicinal properties are likely to be present in Aerva lanata, Javanica and Persica varieties. Traditionally it was used in treating cough, dysuria, hemiplegic migraine and kidney related disorders. Flavonoid glycosides such as Kaempferol, Isorhamnetin, quercetin, flavanone are major phytoconstituents and minor constituents are apigenin, narcissin, ferulic acid, syringic acid and vanillic acid. Alkaloid glycoside includes Ervine, aervine etc. Aerva lanata has much more beneficial activities like demulcent, diuretic, ulcer wounds, rheumatism, Anti-malarial. Pharmacological studies included that aerva species has beneficial properties of antimicrobial, anti-urolithiasis, antiulcer, anti-asthmatic, acute kidney injury, anti-diarrheal activity, antioxidant, antihyperglycemic, hypolipidemic and antiulcer. Aerva lanata has promising role in the treatment of various diseases and metabolic disorders due to its higher antioxidant effect and other such constituents thereby providing better healthcare. Various such constituents are to be analyzed properly and to ensure that it was suffice to exhibit the pharmacological activity. Analytical methods are to be used promptly to find various concentration of substances present in the alcoholic extract of Aerva lanata plant.

Ankul singh

The World Health Organization (WHO) has recently made recommendations for treating all Human Immunodeficency Virus (HIV/AIDS) patients irrespective of their immune status. This issue poses challenges to lower-middle-income countries like Nigeria due to resource limitations. This study performed a budget impact analysis (BIA) of different strategies for the initiation of antiretroviral therapy (ART) among individuals living with HIV/AIDS in Nigeria. A dynamic cohort budget impact model was used to compare two initiation arms (CD4 < 350> 500 cells/ml), with CD4 > 500 cells/ml representing the 2015 WHO guidelines for initiation of ART. Outcomes were hospitalization costs, new infection transmission, and overall budget impact. Key inputs included HIV prevalence in Nigeria, ART access and costs, hospitalization rates and costs, ART uptake trends, and transmission rates. Sensitivity analysis empolyed Monte Carlo simulations to assess the impact of selected parameters. At the end of year five, applying the 2015 WHO guidelines reduced new HIV transmissions by 87.0%, preventing 77,000 infections. Hospitalization cost reductions saved $1.12 million. Overall budget impacts were $718 million for immediate initiation versus $903 million for deferred initiation, yielding $184 million in savings. Monte Carlo simulations showed reduced transmission as the main driver of savings. Prioritizing early treatment initiation espoused by the 2015 WHO guidelines maximize resource efficiency, reduces long-term healthcare costs, and accelerate progress toward epidemic control targets. The findings strongly support the adoption and sustained implementation of the 2015 WHO guidelines for immediate ART initiation. It has public health and economic benefits.

Mediterranean journal of pharmacy and pharmaceutical sciences

Gingivitis, a reversible inflammation of the gums leads to an advancement to periodontitis, a more severe and often irreversible stage characterized by the destruction of connective tissue and bone, potentially leading to tooth loss. This study was designed to develop and evaluate muco-adhesive buccal films containing metronidazole for localized treatment of periodontal disease, aiming to reduce systemic side effects and improve therapeutic efficacy. Thin films were prepared using chitosan as the primary polymer, combined with various copolymers (HPMC, MC, EC, PVP, HPC, and Carbopol) via the solvent casting technique. Thirteen formulations (F1-F13) were investigated for their ability to control the in vitro drug release, surface pH, folding endurance, drug content uniformity, and muco-adhesion, in addition to studying drug release kinetics. Formulations F12 (60.0% HPMC, 20.0% chitosan) and F13 (20.0% HPMC, 60.0% chitosan) showed optimal surface pH (≈6.7-7.0) with high muco-adhesion characteristics (49-51 Mn/m). Sustaining or expediting the drug release rate was manipulated by tailoring the polymer composition within the studied formulations. Examining drug release data has shown that the release kinetics followed the Korsmeyer-Peppas model, indicating diffusion and polymer relaxation mechanisms. The study demonstrates that polymer selection, in addition to the chosen ratio allows customization of release kinetics, Formulation F9 (20.0% HPC, 60.0% Chitosan) was proven to have the ability to provide the most sustained release characteristics. These findings support the potential of chitosan-based muco-adhesive films as effective localized delivery systems for metronidazole in periodontal therapy.

Mediterranean journal of pharmacy and pharmaceutical sciences

Researchers have developed several authentication techniques for route predictions based on user requirements. These techniques estimate the shortest path and available resources in vehicular communication networks. In the current research, the existing authentication techniques for vehicular communication are compared and their inadequacies are identified. Then, new authentication technique based on route forecasting are presented for vehicular communication networks, with the service provider anticipating alternate routes for customers if the current routes have more network traffic congestion. By presenting the most efficient route, the suggested model allows users to maximise their time efficiency. Using A* algorithm, VCN agent seeks path with less network traffic congestion. This algorithm determines the shortest path between a source and a destination. Users are provided with several options by the service provider. User accepts the finest option that meets their needs. This method allows the service provider to deliver at least 15 routes within three seconds. This strategy is beneficial when a significant number of vehicles are stuck in traffic and consumers require network resources to utilise their time effectively.

Vartika agarwal

Objective: Improving quality work by infusing a “sense of belongingness” in lowest-level workers. The present work focuses on the management of human resources in an enterprise where contract workers are involved in carrying out quality work related to the parent organisation. In today’s world, where the number of supervisors has reduced significantly, it is a challenge to maintain the quality of work at a satisfactory level. The paper proposes to enhance the quality of work by infusing a “sense of belongingness” into lowest-level workers. Methodologies adopted: Case studies. The first case study was conducted between 2007-2011 during a project related to Rural Electrification Work in the Bokaro district under the scheme RGGVY. The author was deputed to supervise the rural electrification work of 300 villages with thousands of kilometres of 11kv and 415V distribution lines, along with over 400 distribution transformers in four blocks of the Bokaro district in Jharkhand. Contractors engaged local workers for erection of all infrastructure. The author explained the process of erection to local communities and brought about a sense of belongingness in them towards the infrastructure being developed. The second case review was conducted between 2013-16 at Chandrapura, Bokaro, during the operation and maintenance work of the 220KV switchyard. Six workers were involved in the maintenance work of the switchyard. They rectified faults during emergencies and took care of housekeeping. However, they only followed orders and never worked proactively. The author divided the workplace into eighteen parts, each maintaining three parts. During monthly walk-in inspections, one worker was awarded as the best contractor’s employee of the month of that section, which introduced a sense of competition among them. Analysis: During the first case study, after pointing out the benefits of the infrastructure being developed and how the quality of work will help in its sustainability for an extended period, villagers realised its importance in their well-being. As a result, they kept vigil over the contractor’s work during the erection process. In second case study, the repetitive external motivation (awards and appreciation) infused a “sense of belongingness” in them. Thus, all employees started functioning proactively. As a result, the occurrence of electrical faults was reduced drastically, and housekeeping improved. Findings: These two case studies lead the author to coin the term “sense of belongingness”, which can lead to improve the quality of work by the lowest-level workers in a company. There are five ways to develop a “Sense of Belongingness” (SOB) among workers- external motivation, which can lead to internal motivation; mutual respect; a sense of duty (every person has their own responsibility); brainstorming sessions (to make them feel as an integral part of the department); encouraging them to do more than expected. Conclusion: All these steps help to develop a “sense of belongingness” among the lowest-level workers in an organisation. Without these principles, it will be a challenge to achieve quality work. The paper addresses all the processes in detail to improve the work culture in a department and, ultimately, an organisation.

Rajiv ranjan sinha

Critical race theory (CRT) is an intellectual movement that seeks to understand how white supremacy as a legal, cultural, and political condition is reproduced and maintained, primarily in the US context. While CRT is part of a much longer research tradition investigating race and racism, which includes such key fgures as W. E. B. Du Bois, Frantz Fanon, Angela Davis, Audre Lorde, Gloria Anzaldúa, Cherríe Moraga, and many more, CRT distinguishes itself as an approach that originated within legal studies (in part building from and responding to critical legal studies); aims to be a vehicle for social and political change; has been adopted interdisciplinarily across many fields, including perhaps most notably education; and, in certain contexts, has come to be the umbrella term for studies of race and racism generally. CRT originated as an extension and critique of critical legal studies (CLS). It was also an outgrowth of Marxist critical theory that challenged the rationality, impartiality, and purpose of the legal system. According to the tenets of both CRT and CLS, the legal system is a political and ideological institution that, in part, rationalizes and justifies the existence of the state. Te legal system also requires mastery of an arcane and intentionally inaccessible vocabulary and a set of knowledge and power processes that limit ordinary people’s access to it. Te arbiters of law pretend to rely on reason but actually rely on subjective, politically motivated, culturally biased, and quasi-religious rationale for making and enforcing their decisions. CRT maintains the critique of legalistic thinking found in critical legal studies, but then adds a framework for understanding white supremacy as an immutable fact of a neocolonial state, as well as a praxis for changing it. What separates CRT from other forms of racial critique is that, “Unlike most of the earlier genres of race cholarship, critical race scholarship does not treat race as an independent variable; rather, it regards race as a site of struggle” (Orbe & Allen, 2008, p. 209).

Kamal singh

Garcinia cambogia, commonly known as Asam Gelugur, has entrenched itself as a traditional herbal medicine, renowned for its applications in treating obesity and its integration into global nutraceutical formulations. The bioactive compounds within, particularly hydroxy citric acid, mediate various effects. This study aims to assess the in vitro cytotoxicity of Taxol, a cytotoxic drug used as a control, and the aqueous extract from Garcinia cambogia against the Vero cell line - a kidney-like cell. Cytotoxicity was evaluated using the 3-(4,5-dimetyl-2-2thiazolyl)-2, 5-diphenyl-2H-tetrazolium bromide (MTT) assay. The assay relies on mitochondrial succinate dehydrogenase's potential to reduce MTT, providing a colorimetric indication of cell viability. The results revealed an IC50 value exceeding 500 µg/mL for the aqueous extract from Garcinia cambogia significantly higher than Taxol's 0.0581 µg/mL. This higher IC50 value implies lower toxicity, positioning the Garcinia cambogia extract as a safe component in nutraceuticals and herbal supplements. The aqueous extract of Garcinia cambogia demonstrates low cytotoxicity, reinforcing its safety profile for use in nutraceuticals, which contributes valuable insights into the safety considerations of incorporating Garcinia cambogia into herbal supplements.

Mediterranean journal of pharmacy and pharmaceutical sciences

Rhizosphere actinomycetes are promising biocontrol agents for use in agriculture and have been isolated from various plant species. In the present investigation, actinomycetes were isolated from rhizospheric soil of maize to test antagonistic activity against Fusarium verticillioides and fungal strain (T. viride) were procured from National fungal culture collection of India (NFCCI), T. harzianum and A. niger were isolated from soil to test their antagonistic effects against Fusarium verticillioides. In the present study bio-control dual inoculum method were followed to evaluate the bacterial and fungal strains against the pathogen and reveals that Single Bacterial Inoculum (SBI) of S. cinereus shows more effective in controlling the growth of Fusarium verticillioides (28 mm in treated plate) compare to control (45 mm fungal growth). But in Dual Bacterial Inoculum (DBI), the combination of S. albosporous and S. cinereus shows more effective (08 mm fungal growth in treated plate) compare to control (52 mm fungal growth). Similarly, in Single Fungal Inoculum (SFI), T. harzianum were more effective (18.8 mm fungal growth) and in Dual Fungal Inoculum (DFI), T. viridae and T. harzianum act as a more effective (2.5 mm fungal growth) against Fusarium verticillioides compare to controls (60 mm and 52 mm fungal growth respectively). Overall interpretation of the present work reveals that DBI and DFI were more effective than SBI and SFI against Fusarium verticillioides.

Veerabhadraswamy al

A short review on the multi-use of this ancient herb, German Chamomille. Presented is a synthetic route to azulene, its most bioactive principle (antioxidant, disinfectant, wound-healing, antibacterial).

Stefan dahl

Learning styles describe how individuals acquire, interpret, and assimilate knowledge differently. The effective use of learning styles is essential for effective classroom education. The three most popular learning styles are kinaesthetic, auditory, and visual. This study pursued to learn more about the preferred learning modes of college students. There were 152 respondents from Baneshwor Multiple Campus, Kathmandu Nepal. The data were collected from first year students of BBS, B.Ed. and BA. The researchers used a scale of learning styles (VAK) with 28 items to accomplish the study's goal, and after confirming its validity and reliability, it was applied to the sample. The results show that there are no statistically significant differences in the types of learning patterns preferred by students. Based on these findings, the study recommends that teachers are encouraged to diversify college teaching strategies and methods to suit the preferred learning styles of their students, particularly new students, in order to motivate them to learn in the college environment and to provide the training needs and requirements necessary to enable them to take individual differences among their students into account when identifying educational goals.

Dr dasarath neupane

Corporate Social Responsibility (CSR) is a concept with many definitions and practices. The way it is understood and implemented differs greatly for each company and country. Moreover, CSR is a very broad concept that addresses many and various topics such as human rights, corporate governance, health and safety, environmental effects, working conditions and contribution to economic development. Whatever the definition is, the purpose of CSR is to drive change towards sustainability. Corporate social responsibility (CSR) is now seen as an integral part of corporate strategy. The main purpose of the study is to analyze the corporate social responsibility (CSR) activities carried out by Hindustan Unilever Limited (HUL). An empirical and analytical study was undertaken whereby the corporate official websites of the companies were analyzed. The most preferred CSR activities were observed to be women empowerment, self-employment, health hygiene and environment. The challenge for the companies is to determine a strong and innovative CSR strategy which should deliver high performance in ethical, environmental and social areas and meet all the stakeholders’ objectives.

Thara s shetty

Fragaria nubicola (Hoof. f) Linn. (Rosaceae) is a medicinally important plant commonly called Wild strawberry. Traditionally, it has been used to treat different diseases. The study was carried out to compile all the previous data in review form based on its distribution, traditional medicinal uses, pharmacology and phytochemistry

Dr. salman ahmed