“Phyllanthus emblica” known to be amla has role in the skin aging influences the changes in skin, including skin dryness, wrinkle, and irregular pigmentation. Initially the 6 day observation has been taken for the ageing activity to be track to study the TREM2 pathway of “Phyllanthus emblica”. Cellular observation and pathway consideration: The environmental impact of pH, Temperature, Humidity and stability of amla fruits is important for the ageing of cells in neuronal cascade of TREM2 Pathway, while studying the fruits cell cycle. The melanin suppression through inhibition of tyrosinase and tyrosinase-related protein-2 activities, the strong antioxidant, and the potent matrix metalloproteinase-2 in cellular observation of tyrosinase pathway. The study aimed to evaluate the anti-skin aging efficacy of amla.

Wahul umesh

The use of performance feedback in the workplace has gained popularity over the years, yet school heads have been challenged in providing it to teachers. In the initial interview, they shared that evaluation results can impact teachers’ motivation, and that feedback should be done carefully. However, they failed to clearly articulate a specific mechanism that had been applied in this vital role. Also, no studies have provided clear detail on the feedback mechanism used by school heads in the past. For this reason, a study explored the feedback mechanisms employed by school heads in conveying the performance evaluation results to teachers. This study employed a narrative inquiry, and interviews were conducted with five school heads and five teachers who were chosen purposively for this research. Responses were recorded using a voice recorder. These responses were transcribed and analyzed using thematic narrative analysis. Based on transcripts, the study identified six emergent themes, such as conversational (one-on-one), relational, reflective, technical, reinforcing, and properly situated mechanisms in conveying performance evaluation results to teachers. Thus, a new feedback mechanism framework was developed.

Manuel caingcoy

Aminopyrine (AM) has been used as a model substrate for investigation of drug metabolism. The major metabolic route is N-demethylation that was confirmed in liver microsomes. The aim of the present study was to identify the human cytochrome P-450 enzyme (CYP) mediating the N-demethylation of 4-di-methylaminoantipyrine (4-DMAA) to 4-methylaminoantipyrine (4-MAA). The contribution of human CYP to the metabolism of (4-DMAA) to (4-MAA) in human was investigated using virus expressed human CYP, human liver microsomes with chemical inhibition studies. The substrate of 4-dimethylaminantipyrine was employed at different concentrations (11.5, 23, 46, 115 and 230 µmol per l) with varying concentrations of selective inhibitors of CYP (CYP1A2), (CYP3A4), (CYP2C8),(CYP2A6), (CYP2D6), (CYP2C19) and (CYP1A1). 4-DMAA and 4-MAA were analysed by HPLC and enzyme kinetic parameters (Km and Vmax) were calculated from the concentration data. The transformation of 4-dimethylaminoantipyrine to 4-methyaminoantipyrine by microsomes prepared from baculovirus-expressed human CYP was pronounced with CYP2D6. The metabolism of 4-dimethylaminoantipyrine was inhibited by 60.0% and 55.17% by a concentration of 100 µmo per l of the known CYP2D6 inhibitors quinidine and moclobemide. The corresponding Ki values were 0.050 and 0.11 mM, respectively. The corresponding IC50 values were 0.06 and 0.13 mM, respectively. The enzyme CYP2D6 apparently has an important role in N-demethyl-ation of 4-dimethylaminoantipyrine.

Mediterranean journal of pharmacy and pharmaceutical sciences

India is not known as a country to be in for a bisexual person. Homosexual acts even within wedlock are a punishable offence in India. Legal battles over provisions in the Indian Penal Code which criminalizes any sexual act “against the order of nature” are rife. Even though Kerala has been hailed as a paradox inside India (mainly due to its human development parameters), the social, cultural and legal environment in the state is hostile to individuals who question hetero-normativity. Non-judgemental and unbiased scientific therapy or counselling are seldom available to sexual minorities. This paper is an attempt to map the experiences of a female who is openly bisexual, and is living in Kerala. An ethnographic interview was conducted where the experiences of the participant are explored, from the relationship dynamics as seen by her, to sexual experiences and difficulties in relationships. A reference is also made to the personal and social support systems that are in place for the Lesbian, Gay, Bisexual, Transgender (LGBT) community in Kerala and their role in initiating discourses regarding the topic. A few pointers for future studies in the topic, especially within the context of Kerala are also put forward.

Dr. chinchu c

Hyperoxaluria is a metabolic disorder responsible for calcium oxalate nephrolithiasis. The study was conducted on glass slides to observe the growth patterns of urinary calcium oxalate monohydrate crystals and their inhibition by 5, 10, 15 and 20 % infusion of Macrotyloma uniflorum seeds. For this purpose, a drop of gel medium (sodium metasilicate of 1.06 specific gravity and 3M acetic acid solution) at pH 5.02 - 5.17 was placed in the middle of a glass slide and converted into a gel. A 1 M oxalic acid drop was dropped to the left, and 1 M calcium chloride and magnesium acetate (1:1) solution was dropped to the right side of the properly formed gel. The glass slide was observed under a microscope till it was completely dried. In the case of the crystal inhibition study, a drop of M. uniflorum infusion was also added on the right side just after adding calcium chloride and magnesium acetate solution. The results without infusion showed detailed morphology and aggregation patterns of observed crystals such as donut, dumbbell, needles, platy, prismatic, rosette, round edges, X-shape crystals, loose and compact aggregates. All infusions of M. uniflorum affected the crystals, forming defective crystals. 5 % infusion inhibited crystals of all morphologies except donuts, X-shaped crystals, donuts, platy crystals and rosettes. Defected rosettes were observed in 10 % infusion, which was reduced gradually in the crowd by 15 and 20 %, respectively. From this study, it can be concluded that M. uniflorum seeds infusion is effective against calcium oxalate nephrolithiasis.

Dr. salman ahmed

The coronaviruses are group of viruses containing about seven members that have genetic material of RNA. They are surrounded by the protein capsid and lipid-containing membrane which has spike protein as flower petals. This family of viruses can infect animals and birds as well as humans causing signs and symptoms of respiratory system. However, these depend on the immune system of the infected host. The COVID-19 pandemic is a major global health disaster and the greatest task have faced the world. The infecting agent of COVID-19 disease was identified on December 31st, 2019 by Chinese scientist in Wuhan City. It was named Novel Coronavirus (Severe Acute Respiratory Syndrome-2 or SARS-2). After that, health minister of China announced that this virus is a new Coronavirus and it is of very high contagious rate [1]. In spite of the existence of many infectious cases in Libya at the winter season, the National Center of Disease Control (NCDC) announced about the first case of coronavirus on March 24th, 2020. It was identified by using a RT-PCR technique for a patient who came from Saudi Arabia. The NCDC, which is the government corporation responsible for the COVID-19 in Libya, has a daily news report about COVID-19 situation, including numbers of new cases infected patients, healing cases and total deaths number all over the country

Mediterranean journal of pharmacy and pharmaceutical sciences

Flow control techniques are broadly classified into two types 1.passive control 2.active control. Present paper discuss about the experimental investigation of flow control using passive method on bluff body. Authors also explains about the various flow control techniques used in bluff body aerodynamics. Experimental setup consists of L m span and diameter d of cylinder model. The next model is having strip of cross section 0.01d dia is placed on the cylinder along the span wise distance with equal polar distance around 30o. both the models were kept between four walls in a Reynolds number ranging from 10000 to 15000. The results show that the Cp values changes according to the changes in cylinder roughness.

Boopathy govindarajan

Animals like plants are also medicinal agents for preventing and curing different health problems worldwide, practically in all human cultures. Zootherapy is ancient and has strong evidence of the medicinal use of animal resources. Different animal body parts and preparations are used in folk medicines. Zootherapy reveals that medical practitioners have always considered animals a source of surprising and numerous therapeutic effects. A high diversity of animals, their parts, and derivative products are used, and this is a heritage that could constitute a fundamental step in the discovery and isolation of natural extracts and new and low-cost alternative drugs from animals. About 12% of people worldwide are affected by different types of urolithiasis; the recurrence rate in females is 47-60%, and in males is 70-80%. According to WHO, 75% of the population relies on traditional medicines to prevent and cure diseases. Hence, there is a need to concentrate on all folk natural products effective in urolithiasis for their pharmacological evaluation and isolation of single drug molecules responsible for anti-urolithiasis activity to develop suitable formulations against urolithiasis.

Dr. salman ahmed

Financial sector needs special attention pertaining to incorporation of the ESG criteria. Economic and financial issues coupled with climate change would have negative impact on the stability of financial institutions. This research paper attempts to synthesize and summarise scholarly articles published in Scopus database on ESG domain with reference to banking sector using bibliometric analysis. The objective of this review paper is to understand from past literature the trajectory of studies in the domain of ESG. There is a substantial growth in frequency of publication in the year 2022 along with annual growth of around 30 percent during 2015-2023. Bibliometric with MS-Excel, R-Studio and VOS-viewer were used to identify and analyze research trends related to the number of studies, research fields, authors, nations, institutions, and keywords. The important keywords identified in the bibliometric analysis were sustainability, corporate social responsibility, sustainable finance, banks performance.

Dr. mohammed nizamuddin

Alzheimer Disease is a chronic neurological brain disease. Early diagnosis of Alzheimer illness may the prevent the occurrence of memory cellular injury. Neuropsychological tests are commonly used to diagnose Alzheimer’s disease. The above technique, has a limited specificity and sensitivity. This article suggests solutions to this issue an early diagnosis model of Alzheimer’s disease based on a hybrid meta-heuristic with a multi-feed-forward neural network. The proposed Alzheimer’s disease detection model includes four major phases: pre-processing, feature extraction, feature selection and classification (disease detection). Initially, the collected raw data is pre-processed using the SPMN12 package of MATLAB. Then, from the pre-processed data, the statistical features (mean, median and standard deviation) and DWT are extracted. Then, from the extracted features, the optimal features are selected using the new Hybrid Sine cosine firefly (HSCAFA). This HSCAFA is a conceptual improvement of standard since cosine optimization and firefly optimization algorithm, respectively. Finally, the disease detection is accomplished via the new regression- based multi-faith neighbors’ network (MFNN). The final detected outcome is acquired from regression-based MFNN. The proposed methodology is performed on the PYTHON platform and the performances are evaluated by the matrices such as precision, recall, and accuracy.

Dr. rajasekhar butta

Cet article porte sur l’ouvrage Le ventre, le pain ou la cendre de Tchicaya U Tam’si. À partir des approches linguistique, stylistique et sémiotique, nous avons tenté de montrer, dans notre analyse, en quoi l’écriture de ce recueil construit des stratégies discursives propres à retenir l’attention du récepteur. À cet effet, nous avons relevé deux principales figures de rhétoriques à savoir, l’emphase et l’hyperbole. Ces deux procédés de style produisent d’une part un effet d’insistance du procès poétique ; et de l’autre, un effet d’amplification du langage poétique.

Assanvo

This study examines Javanese Krama's learning in improving students' ability to speak politely at MIMA 35 Nurul Ulum Ambulu. This research approach is a descriptive qualitative approach, and the type of research used is phenomenology. Data collection techniques using interviews, observation, and documentation. While the data analysis using the model of Miles, Huberman, and Johnny Saldana consists of data condensation, data presentation, and conclusion. The results of this study are 1) Planning for learning the Javanese Krama language to improve the ability of students to speak politely at MIMA 35 Nurul Ulum Ambulu, namely: the teacher prepares a Learning Implementation Plan, prepares to memorize material for the Javanese Krama language vocabulary for students. 2) Implementation of Javanese Krama language learning in improving the ability of students to speak politely at MIMA 35 Nurul Ulum Ambulu, namely: opening, core, and closing activities. Then the habit of using Javanese manners during learning hours and outside the classroom. 3) Evaluation of Javanese Krama language learning in improving the ability of students to speak politely at MIMA 35 Nurul Ulum Ambulu, namely: in the classroom using daily questions, PTS and PAS. Meanwhile, habituation outside of learning hours is by assessing students' speech and manners. 4) The implications of learning Javanese Krama in improving the ability of students to speak politely at MIMA 35 Nurul Ulum Ambulu have a positive impact on students becoming accustomed to using Javanese Krama when communicating with teachers both in attitude and speech.

Educare: journal of primary education

“Phyllanthus emblica” known to be amla has role in the skin aging influences the changes in skin, including skin dryness, wrinkle, and irregular pigmentation. Initially the 6 day observation has been taken for the ageing activity to be track to study the TREM2 pathway of “Phyllanthus emblica”. Cellular observation and pathway consideration: The environmental impact of pH, Temperature, Humidity and stability of amla fruits is important for the ageing of cells in neuronal cascade of TREM2 Pathway, while studying the fruits cell cycle. The melanin suppression through inhibition of tyrosinase and tyrosinase-related protein-2 activities, the strong antioxidant, and the potent matrix metalloproteinase-2 in cellular observation of tyrosinase pathway. The study aimed to evaluate the anti-skin aging efficacy of amla.

Dr. wahul umesh b

Kompetensi pedagogik merupakan kemampuan yang harus dimiliki guru dalam mengelola pembelajaran. Berkaitan dengan pengelolaan Pembelajaran Tematik fakta di sekolah menunjukkan banyak guru belum sepenuhnya mampu mengimplementasikan pembelajaran yang memiliki prinsip mengintegrasikan banyak materi. Untuk itu, penelitian ini bertujuan untuk mendeskripsikan kemampuan guru: 1) Memahami peserta didik dalam melaksanakan Pembelajaran Tematik di MI Miftahul Hidayah Tegalsari Tahun Pelajaran 2018/2019. 2) Merencanakan pembelajaran dalam melaksanakan Pembelajaran Tematik di MI Miftahul Hidayah Tegalsari Tahun Pelajaran 2018/2019. 3) Melaksanakan pembelajaran pada Pembelajaran Tematik di MI Miftahul Hidayah Tegalsari Tahun Pelajaran 2018/2019. 4) Mengevaluasi hasil belajar dalam melaksanakan Pembelajaran Tematik di MI Miftahul Hidayah Tegalsari Tahun Pelajaran 2018/2019. Hasil penelitian menunjukkan bahwa: 1) Kemampuan guru memahami peserta didik sudah sesuai indikator kompetensi pedagogik. 2) Kemampuan guru merencanakan pembelajaran sudah sesuai dengan indikator kompetensi pedagogik. 3) Kemampuan guru dalam melaksanakan pembelajaran ada satu indikator yang perlu diperbaiki. 4) Kemampuan dalam mengevaluasi hasil belajar sudah sesuai dengan indikator kompetensi pedagogik.

Educare: journal of primary education

We present a series of large-eddy simulations to systematically investigate the impact of debris accumulation on the hydrodynamics and power production of a utility-scale marine hydrokinetic (MHK) turbine under various debris loads lodged on the upstream face of the turbine tower. The turbine blades are modeled using turbine resolving, actuator line, and actuator surface methods. Moreover, the influence of debris on the flow field is captured by directly resolving individual logs and employing a novel debris model. Analyzing the hydrodynamics effects of various debris accumulations, we show that an increase in the density of debris accumulation leads to more flow bypassing beneath the turbine blade. This, in turn, reduces the flow momentum that reaches the MHK blades at the lower depths, inducing significant fluctuation in power production. Further, it is shown that debris-induced turbulent fluctuations contribute to significant variability in the MHK turbine’s power production.

Hossein seyedzadeh

Lifelong learning is becoming part of the philosophy of professional education. Continuing medical education is the responsibility of all personnel who are responsible for the delivery of components of the health care delivery system. Continuing education is becoming increasingly obvious for medical universities, hospitals, and health care providers. Pharmacists who practice in a community pharmacy and hospital, and who are participating in residency recognize that the traditional role of the pharmacist is changing. Over the last decades, a host of new services have been identified as a function of the pharmacist [1]. A review of these services revealed a personal commitment to continuing education. It is the absolute need to develop a level of competence that will improve patient care. In Libya, pharmacists working in the community practice setting are pharmacists with a diploma of pharmacy or with a Bachelor of Pharmaceutical Science, Master of Science, and Doctor of Pharmacy (Pharm D). The main objective is that the graduates possess the knowledge and skills needed to perform optimally to man the pharmaceutical services [1, 2]. Patient's expectations from pharmacists are that the medicine should be effective, safe and affordable. Other expectations from Libyan pharmacists would be to dispense the drugs according to the rules with the right advice on how and when the medicines should be used, and what to do in the case of adverse drug reactions, and the provision of advice on common illnesses. Nevertheless, it is an undeniable fact that the pharmacist has failed to provide all these patient-oriented services [3]. It should be noted that the quality of pharmacy education and training can be improved through certain processes of accreditation.

Mediterranean journal of pharmacy and pharmaceutical sciences

Étudier les phénomènes grammaticaux actuels sans s’interroger sur la longue trajectoire historique qui a servi de support et de canal au français moderne manquerait de pertinence. En effet, une telle étude permet une meilleure compréhension des phénomènes linguistiques contemporains. Ainsi, notre domaine de recherche, la linguistique diachronique, met l’accent sur les connaissances étymologiques de la langue. Il s’agira, pour les besoins de l’article, de rendre compte de l’évolution morphologique du présent de l’indicatif depuis le latin jusqu’au français moderne. Notre curiosité nous poussera à nous interroger sur les raisons qui expliquent l’écart morphologique du présent de l’indicatif entre le latin et le français moderne. En sus, l’étude des variations diachroniques du présent de l’indicatif renseigne sur les formes actuelles de ce temps verbal. Du latin au français moderne, le présent de l’indicatif subit des flottements aussi bien dans ses radicaux que dans ses désinences. Ceci met en chef l’écart formel existant entre le présent latin et celui du français actuel. Toutefois, les phonèmes subirent des transformations selon qu’ils étaient toniques ou atones, radicaux ou désinentiels. Certaines formes se sont maintenues avec modification ou non de sons; d’autres ont complètement disparues du système. Suivant un ordre chronologique et des lois phonétiques cohérentes, nous montrerons que les formes actuelles du temps le plus usuel du système, le présent, ne sont pas le fruit du hasard. De ce fait, la langue moderne gagnerait à revisiter la morphologie des temps verbaux depuis leur origine pour mieux asseoir les difficultés liées à la conjugaison et fournir une explication authentique sur les variations de forme jusque-là ignorées par certains.

Assanvo

The COVID-19 pandemic and related lock downs have accelerated the need for online and remote teaching within university settings. However, due to the abrupt nature of the pandemic, many academic staff were not prepared for this forced transition. This study aimed to understand how the pandemic affected academics at a New Zealand university, with regards to their transition to emergency remote teaching. Specifically, it explores the challenges as well as benefits academics experienced during this transition. Recommendations for future online learning are also made. Academic staff (N 67) at a New Zealand University completed an anonymous online survey. Quantitative data were analyzed statistically using descriptive and inferential statistics, while qualitative data were analyzed thematically. Major challenges experienced included miscommunication from the university, concerns about student access to technology, finding a quiet space to work, lack of digital competence skills, too much screen-time, managing work hours, and work/ life balance. Benefits included enhanced flexibility, enhanced teacher creativity, increasing autonomy of learners, and reduced commute time. Looking forward, academic staff desired future teaching to include blended learning and virtual immersion. New strategies of working remotely are being explored to facilitate teaching and learning while catering to the preferences and skills of both educators and students. Our findings honor the considerable agility of academic staff who sought to sustain and enhance excellence in remote education. At an institutional level our findings point to the need for staff to be supported by their institutions as they further refine their work within new-found spaces

Gwen erlam

healthcare professionals, and academic achievement is essential for students’ success. However, academic procrastination and mobile phone addiction have been identified as challenges that can negatively impact students’ academic performance. This study aimed to explore the relationships among mobile phone addiction, academic procrastination, and academic accomplishment specifically among nursing students. Method: A correlational research design was applied in this study. A sample of 121 nursing students from Tirupati College of Nursing, Udaipur was recruited using a convenience sampling technique. Validated self-report questionnaires were utilised to assess mobile phone addiction, academic procrastination tendencies, and academic accomplishment. The data were analysed using appropriate statistical methods, including correlation analysis and regression analysis. Results: The results show a positive correlation between mobile phone addiction and academic procrastination among nursing undergraduates. However, there was no significant direct effect of mobile phone addiction on academic accomplishment. The study also identified an adverse association between academic procrastination and academic accomplishment, emphasising the detrimental impact of procrastination on students’ academic performance. Conclusion: The findings suggest that nursing students who experience higher levels of mobile phone addiction may have an increased tendency to procrastinate academically. While mobile phone addiction did not directly impact academic achievement, academic procrastination was found to have a negative influence on academic performance. These results underscore the importance of addressing procrastination tendencies among nursing students to improve their academic success.

Dr k c yadav

Pneumonia is an acute pulmonary infection that can be caused by bacteria, viruses, or fungi. It infects the lungs, causing inflammation of the air sacs and pleural effusion: a condition in which the lung is filled with fluid. The diagnosis of pneumonia is tasking as it requires a review of Chest X-ray (CXR) by specialists, laboratory tests, vital signs, and clinical history. Utilizing CXR is an important pneumonia diagnostic method for the evaluation of the airways, pulmonary parenchyma, and vessels, chest walls among others. It can also be used to show changes in the lungs caused by pneumonia. This study aims to employ transfer learning, and ensemble approach to help in the detection of viral pneumonia in chest radiographs. The transfer learning model used was Inception network, ResNet-50, and InceptionResNetv2. With the help of our research, we were able to show how well the ensemble technique, which uses InceptionResNetv2 and the utilization of the Non-local Means Denoising algorithm, works. By utilizing these techniques, we have significantly increased the accuracy of pneumonia classification, opening the door for better diagnostic abilities and patient care. For objective labeling, we obtained a selection of patient chest X-ray images. In this work, the model was assessed using state-of-the-art metrics such as accuracy, sensitivity, and specificity. From the statistical analysis and scikit learn python analysis, the accuracy of the ResNet-50 model was 84%, the accuracy of the inception model was 91% and lastly, the accuracy of the InceptionResNetv2 model was 96%.

Dr. chandrashekhar uppin