Stem cells hold great promise for tissue regeneration and have the potential to treat many incurable degenerative diseases. Cancer stem cells (CSCs), or cancer initiating cells, have the ability to self-renew and differentiate into heterogeneous lineages of cancer cells. Current stem cell therapies face limitations, such as limited stem cell sources, time consumption, tumor formation, and immune rejection upon allogeneic transplantation. Allogeneic stem cell treatments simplify stem cell manufacturing and reduce transplant time, but their therapeutic potential is limited by human leukocyte antigen (HLA)-matched donors. CSCs retain characteristics essential for tissue regeneration. However, several limitations hinder cancer stem cell reprogramming with pluripotent factors. The development of 3D culture models for tissue imitating extracellular matrix in cancer cell lines aims to enhance CSC enrichment. This mini-review focuses on a new strategy for treating incurable degenerative diseases involving in vitro and in vivo 3D cancer models and the induced differentiation of CSCs into mature normal cell types. This allows tissue survival without immune rejection and offers a safe alternative to cancer stem cell reprogramming with pluripotent factors. In conclusion, preservation and banking of allogeneic CSCs offer an alternative, readily available, and safe strategy that can be used to facilitate stem cell-based cell therapy.

Josita alloysius

Scientific research is an extremely important element in higher education. Nearly all undergraduate students at the university are required to take research courses in the formation process. Therefore, the current paper aims to explore Vietnamese undergraduate students’ attitudes towards research. To measure attitudes towards research, the study used Papanastasiou’s Revised Attitude Towards Research (R-ATR) scale (2014). This psychometric proprieties scale consisted of 13 items with three factors: research usefulness (4 items), research anxiety (5 items), and positive research predispositions (4 items). Data were collected by a questionnaire survey on a convenient sample of 520 undergraduate students from six universities in Vietnam. Descriptive and inferential statistics were used to analyze the data. The findings indicated that the students’ attitudes were high in the factor of research usefulness and positive research predispositions. However, in the factor of anxiety, the attitudes were moderate. In addition, the public undergraduate students had significantly more positive attitudes towards research than the private undergraduate students. Similarly significant results were found for gender, year of study, and research experience.

Le minh tien

During the last few years, the pharmacy profession has expanded significantly in terms of professional services delivery and now has been recognized as an important profession in the multidisciplinary provision of health care. The paper highlights the current scenario of The Pharmacy profession in the health care system. The pharmacist is a backbone that strengthens to the health care system. Different roles of Pharmacist in different sectors of the pharmacy profession like Industrial, academics, community health, clinical research, drug design and discovery, developing NDDS etc. In nutshell, pharmacist plays an integral part in the health care system. “Physician gives medicine to the patients but life to the medicine given by pharmacist”. Role of Pharmacist in Health Care System

Kamal singh

Foreign bodies (FBs) in the scalp are a common incident following head trauma, especially in traffic accidents, and are detected in the early post-traumatic period. The persistence of these FBs may cause pain and paresthesia. We report a case of 41 years old man, whose victim it’s been 20 years of physical aggression, in which the victim was hit by a brick occasioning a frontal wound stitched at the time without sufficient exploration. Months later, the patient presented several episodes of a frontal scalp nodular lesion with pus leakage (Fig. 1). The lesions were only treated with local antibacterial agents. Four years before the patient consults at our level, he consulted a dermatologist who performed a removal of the skin lesion. Months later, the lesion reappeared. At our level the clinical examination suspected a bone lesion, so CT was performed. Brain imaging was strongly evoking bone tumors or osteitis (Fig. 2). The patient was operated on under general anesthesia. First, a carcinogenic removal of the scalp lesion was performed; then, when reaching the bone, hard red friable bodies well separated from proportionally healthy bone were found. Those findings raise suspicion of the presence of FBs nested in the bone from the first head trauma. Hence, a carcinologic removal of the affected bone was postponed, and simple curettage was performed (Fig. 3). The post-operative course was without complications. The histological study confirmed per-operative findings: Multiple stony FBs associated with inflammatory reaction especially lymphocytes around vessels and the FBs.

Karishma

This research aims to evaluate the optimization of network security forensic tools on virtual router (VR) traffic. The methodology used includes the selection of several forensic tools on the Windows operating system such as Wireshark, Windump, and Network Miner, with testing in a virtual network environment. Testing, includes simulating various attack scenarios to assess the effectiveness of threat detection, performance of forensic tools, and impact on network performance. The main results show that the tools have varying detection capabilities with variations in resource usage and impact on network latency. Network traffic has been successfully recorded using the Win-dump tool in the static-forensics method, the Wireshark tool and Network Miner in the live-forensics method. The evaluation results of the meta-router network forensic recording tool recommend Win-dump as a recording tool that does not burden the Windows operating system with memory usage of 1696 kb while the Wireshark and Network Miner applications are recorded at more than 20MB. Based on this research, the static forensic method which have been built with meta-router objects can be used by investigators to detect cyber attacks. Proper selection and configuration of forensic tools is critical to achieving a balance between security and network performance, and specific adjustments to network requirements can increase the effectiveness of threat detection and mitigation.

Firmansyah yasin

India’s economic system has undergone significant changes in recent years reflecting globalization and changes in national policies. This paper provides a comprehensive analysis of India’s economic growth, focusing on imports and exports. The study explores the key drivers of economic expansion, including trade liberalization, trade agreements, and technological advancement. It also explores the impact of international trade and geopolitical events on business models. It assesses the role of policy measures such as the Goods and Services Tax (GST), the Make in India initiative, and various free trade agreements in generating economic benefits. The paper also assesses the trade balance and its impact on India’s economic stability and growth. The paper concludes with recommendations for improving the market, including diversifying entrepreneurs, investing in infrastructure, and strengthening the domestic economy. The review provides insights to policymakers, businesses, and academics who want to understand and harness India’s economic potential in the global economy

Dr gedam kamalakar

भारतीय मध्यकालीन समाज और संस्कृति की समझ रखने और समझने की कोशिश करने वाले हरेक अध्येता की नज़र इस ओर जाती है कि बाज़ार भक्तिकालीन कवियों के बात करने का एक ख़ास बिन्दु रहा है। जहाँ ये कवि बाज़ार को सबसे अधिक जनतांत्रिक जगह के रूप में प्रस्तुत करते रहे हैं, चाहे वे कबीर रहे हो रैदास हो या फिर तुलसी। ये कवि हमें होशियार भी करते हैं कि बाज़ार में सारी भौतिक चीजें बिक रही हैं आप उन्हें खरीद सकते हैं मगर प्रेम आप नहीं खरीद सकते। ये कवि प्रेम की लगातार वक़ालत करते है। इनके पास दुनिया को खूबसूरत बनाने का एक ही रास्ता है -प्रेम। वे बताते हैं कि कैसे ये भौतिक चीजें मनुष्य के प्रेम को ब्रह्म यानी ज्ञान या मानवता के रास्ते में रोड़ा बन जाती हैं। साथ ही कैसे भौतिक चीज़ें आज अपनी पाँव तेजी से पसारती जा रही हैं।

Manish patel

This study was carried out to evaluate the effects of thermal processing techniques on the nutrient and antinutrient contents of pigeon pea (Cajanus cajan) flours. The pigeon pea seeds were sorted, cleaned and divided into five equal lots of 0.5kg each. Four lots of pigeon pea seeds were processed into blanched, boiled, roasted, and autoclaved pigeon pea flours, while the fifth lot was processed raw and used as control. The raw and thermally processed samples obtained were analysed for nutrient and antinutrient composition using standard methods. The proximate composition of the samples showed that the flours had a range of 8.61 - 11.46 % moisture, 21.13 - 23.94 % crude protein, 1.26 - 1.68 % fat, 5.12 – 6.10 % crude fibre, 1.74 – 2.97 % ash, 55.56 – 60.41 % carbohydrate and 333.45 - 342.75 kJ/100g energy, respectively. The mineral composition showed that the flours contained 86.24 – 144.72 mg/100g calcium, 137.80 – 170.33 mg/100g magnesium, 125.86 - 156.76 mg/100g potassium, 66.66 – 95.62 mg/100g sodium, 4.38 – 6.64 mg/100g iron and 130.27 – 178.29 mg/100g phosphorus, respectively. The vitamin content of the flours were 3.09 - 4.33 mg/100g ascorbic acid, 0.05 - 0.17 mg/100g thiamine, 0.03 - 0.21 mg/100g riboflavin, 0.13 - 0.28 mg/100g niacin, 3.21 - 6.25 mg/100g vitamin A and 1.10 - 2.70 mg/100g vitamin E, respectively. The antinutrient composition of the flours also showed that the levels of trypsin inhibitor, tannin, phytate, oxalate, saponin and haemagglutinin ranged from, 2.30 – 5.61 Tiu/mg, 0.81 – 1.5mg/100g, 1.12 - 4.18mg/100g, 0.48-4.01 mg/100g, 1.28 – 3.66 mg/100g and 1.30 – 7.44 Hiu/g, respectively. Therefore, the study showed that thermally processed pigeon pea flours could be used as nutrient dense ingredients in the preparation of a wide range of foods for children, adolescents and aged adults especially in developing countries where the problems of protein-energy malnutrition and micronutrients deficiencies are prevalent than the raw sample.

Okechukwu obed chukwuemeka

Mosquitoes conveying Plasmodium store parasites into the skin of the mammalian host. Parasites make a trip through the circulation system to the liver, where they cross a few hepatocytes prior to building up a disease. Inside the last hepatocyte the parasite goes through morphogenesis and afterward abiogenetically partitions to become more than 20,000 blood-infective parasites, called merozoites. On account of P. vivax, P. ovale, and P. cynomolgi, the parasites can stay lethargic in the liver in structures called hypnozoites. The merozoites are delivered once again into the circulation system, where they start the repetitive blood stage. Inside erythrocytes, a little division of parasites separate into male or female gametocytes. These gametocytes are ingested by the mosquito during blood taking care of, where they will duplicate explicitly, in the long run prompting the arrangement of sporozoites

Rukshi naaz

Ambon Bay consists of the inner Ambon Bay (IAB) and the outer Ambon Bay (OAB) and they are separated by the shallow sill (12 m) Galala-Rumah Tiga. The topography of the bay makes it unique and causes the exchange of water mass between those two parts of the bay does not follow the daily tidal cycle. The aim of this study was to analyze the vertical and horizontal temperature and chlorophyll-a distribution in order to know the water circulation in Ambon Bay. This study was carried out during the monsoon, in November 2018. The CTD was used to measure in situ temperature and chlorophyll-a concentration. The data were analyzed by using Surfer and ODV programs. The results show that the temperature of the surface water (0-5 m) of Ambon Bay was 29.2℃. In depth 15-40 m, temperature was different between the IAB (27.7-28.2℃) and OAB (29,2-28.7℃). Chlorophyll-a concentration was found higher in the IAB than in OAB in all depths. In the depth >12 m, chlorophyll-a in the IAB was 1 mg/m3 compared to its concentration in OAB only 0.3 mg/m3. As a conclusion, the sill in Ambon bay causes unique circulation of water mass between IAB and OAB based on the analysis of temperature and chlorophyll-a concentration distribution.

Irma kesaulya

Social Network sites are one of the most prominent websites used in almost every facet of life. A social network reflects relationships among social entities, including acquaintances, co-workers, or co-authors. With the extreme success of Social networks, the misuse has also been escalated and unlocked the way for various illegal behavior and security threats. Social Network anomaly detection has become a critical topic to be explored by researchers. The nature of the input data is a significant aspect of an anomaly detection technique. In the field of anomaly detection in the social network, input networks can be classified as static or dynamic, Attributed or unattributed. The number of nodes and the connections between the nodes in static networks would not change with time. Attribute networks are pervasive in various domains and constitute a vital element of modern technological architecture, where node attributes support the topological structure in data exploration. While social networks build up over time, evaluating them as if they had been static is very beneficial. Numerous studies have been done for Anomaly detection, but to the best of our knowledge, research in static attributed anomaly detection has been very limited. This review tries to portray earlier research on detecting anomalies for social static attributed networks and thoroughly discusses state-of-the-art embedding approaches

Mohd haroon

Fungsi pendidikan adalah untuk mengembangkan karakter peserta didik. Oleh karenanya, guru dituntut agar dapat mengembangkan karakter melalui proses pembelajaran diantaranya melalui pembelajaran tematik. Salah satu sikap yang dapat dikembangkan melalui pembelajaran tematik adalah karakter mandiri. Penelitian ini bertujuan untuk mendeskripsikan perencanaan, pelaksanaan serta faktor-faktor yang mempengaruhi pengembangan karakter mandiri melalui pembelajaran tematik pada kelas III di Madrasah Ibtidaiyah Negeri 5 Jember. Penelitian ini menggunakan pendekatan kualitatif dengan jenis fenomenologis. Teknik pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Hasil penelitian ini adalah: 1) perencanaan pembelajaran tematik dalam pengembangan karakter mandiri di Madrasah Ibtidaiyah Negeri 5 Jember diwujudkan dalam RPP yang disusun secara sitematis dan berbasis karakter dengan memasukkan karakter mandiri pada komponen kompetensi inti, kompetensi dasar, indikator, kegiatan pembelajaran, dan penilaian; 2) pelaksanaan pengembangan karakter mandiri pada pembelajaran tematik dilakukan melalui kegiatan pembelajaran mulai dari kegiatan pendahuluan, inti dan penutup. Namun kegiatan inti lebih dimaksimalkan dengan menggunakan model learning by doing dengan melakukan lima aktivitas belajar yaitu menanya, mengamati, mengumpulkan informasi, mengasosiasi, dan mengkomunikasikan; dan 3) faktor-faktor yang mempengaruhi pengembangan karakter mandiri yaitu lingkungan keluarga, lingkungan sekolah dan lingkungan masyarakat.

Educare: journal of primary education

A simple, rapid, sensitive reversed-phase high-performance liquid chromatography method was developed and validated for simultaneous measurement of albendazole and praziquantel with an internal standard, simvastatin, at single wavelength of 225 nm. Chromatographic separation was performed on an Enable C18 column (250 mm × 4.6 mm, 5 μm: Spinco Biotech Pvt Ltd) and a mobile phase consisting of acetonitrile:water (60:40, v/v) with 10% orthophosphoric acid to adjust the pH to 3.2, at a flow rate of 1.0 ml/min. The calibration curve was linear (r2 ≥ 0.999) over the concentration range 0.05–8.0 μg/ml. The concentrations of simvastatin was 1.0 μg/ml. The limit of quantification was 0.05 μg/ml for both albendazole and praziquantel. No interference was found by the excipients in the synthetic mixture. The proposed methods were validated as per International Conference on Harmonisation guidelines for linearity, accuracy, precision and robustness for estimation of albendazole and praziquantel in bulk and in a synthetic mixture, and the results were found to be satisfactory.

Prasanna pradhan

Various types of security attacks are normal in vehicular communication networks. The current study uses a support vector machine to implement a Point to Point Critical Path Monitoring (P2PCPM) based Denial of Service (DOS) Attack detection technique for Vehicular Communication Network (VCN) resource management. Greatest quality of P2PCPM is that it eliminates attacked nodes from the network for the smooth process of vehicular communication. This scheme works well in terms of accuracy as well as attack detection rate. The whole simulation is made and tried by utilizing MATLAB Software. Simulation result shows 99% accuracy in case of security attack detection as well as reduced training and testing error upto 2%. Experimental results indicate that this scheme has a great efficiency and works well up to 1000 nodes, which is the limitation of current implementation. In future, simulation test may be done for unlimited nodes using similar or other techniques of attack detection.

Vartika agarwal

There are more and more multinational enterprises growing in Indonesia that makes foreign employees are increasing every year. Thus, it is important for local workers to understand the leadership style of expatriates from the companies’ leaders and managers. The purpose of this research is to see the effect of transformational leadership style on job satisfaction conducted at PT Musim Mas, Medan. This research uses quantitative method with simple random sampling of 36 employees working in the company. The test results show that transformational leadership style has a positive significant effect on job satisfaction at PT Musim Mas, Medan as much as 69.5%.

L

Urolithiasis is a common worldwide problem with high recurrence. This review covers thirteen (13) antiurolithiatic plants of the family Boraginaceae, twenty (20) from Brassicaceae, twenty-three (23) from Malvaceae and twenty-four (24) from Poaceae used globally in different countries. Hopefully, this review will be helpful for the general public and attract the scientific world for antiurolithiatic drug discovery.

Dr. salman ahmed

Les études sur la langue française la présente souvent dans des situations où elle est en contact avec les langues africaines. Elle co-apparait avec les langues africaines dans les discours romanesques. Cette co-apparition n’est pas sans conséquences pour les deux langues en contact. Certains linguistes, surtout les sociolinguistes et les didacticiens, parlent d’insécurité linguistique. Ils la lient à toutes les situations linguistiques où deux langues entrent en contact. Ngamassu (2007, p.94) dit dans ce sens que « toute situation de contact des langues est source d’insécurité linguistique, car aucun locuteur/scripteur ne peut maîtriser toutes les variétés ou niveaux d’une langue ». Cette affirmation restreint l’insécurité au locuteur ou au scripteur. Les linguistes ignorent souvent l’impact négatif du contact des langues et s’intéressent à ses conséquences positives. Cet article a porté sur les manifestations de l’insécurité linguistique dans la prose romanesque de Kourouma et Badaman. Il a permis de voir que l’usage des langues maternelles dans le français constituait une menace de disparition et d’abâtardissement de la langue française.

Assanvo

In the present study the effect of the ethanol extract of Culcasia falcifolia on the neurotransmitter levels were evaluated. Pentylenetetrazole (PTZ) (60 mg/kg body weight, i. p) was administered to all the groups of mice to induce convulsions. After observing the convulsion, all groups rats were sacrificed, whole brain was dissected out and separated the forebrain. The brain tissue was homogenized and then centrifuged. The aqueous phase was taken for the assay. The reading was obtained using spectroflurimeter. The result of the present study shows that the ethanol extract of Culcasia falcifolia at the dose of 200 and 400 mg/kg body weight significantly increased the level of inhibitory neurotransmitter GABA and also showed significant increase in the levels of dopamine, noradrenalin and serotonin when compared to seizure control group (PTZ treated group) and was almost equivalent to control group. The findings of the study showed that the extract at 200 and 400 mg/kg body weight significantly (p<0.001) increased the levels of GABA, dopamine, serotonin and noradrenaline. The ethanol extract of Culcasia falcifolia exerted antiepileptic activity by decreasing seizure susceptibility to pentylenetetrazole-induced seizure in mice due to restoration of GABA, serotonin, dopamine and noradrenaline concentration levels in mice brain.

Gracelyn portia

Pendidikan agama Islam sebagai upaya mengembangkan, mendorong serta membimbing peserta didik hidup lebih dinamis dengan berdasarkan nilai-nilai agama islam dan terbentuk pribadi peserta didik insane kamil. Rumusan dalam dalam peneltian ini: 1) Bagaimana peran PAI dalam pembinaan kesehatan mental siswa di SDN Sekarputih 1 Tegalampel Bondowoso? 2) Bagaimana peran PAI dalam pembinaan kesehatan pikiran/intelektual siswa di SDN Sekarputih 1 Tegalampel Bondowoso? Metode penelitian ini menggunakan pendekatan kualitatif deskriptif dan jenis penelitian studi kasus. Metode pengumpulan data dengan metode observasi, metode wawancara dan metode dokumentasi. Sedangkan analisis data menggunakan model analisis interaktif Milles, Huberman dan Saldana dengan tiga Langkah dalam proses analisis data yaitu: kondensasi data, penyajian data dan penarikan kesimpulan. Untuk memeriksa keabsahan data ini, menggunakan tehnik triangulasi yaitu triangulasi tehnik, triangulasi metode dan triangulasi data. Berdasarkan hasil penelitian ini dapat disimpulkan: (1) Peran PAI dalam pembinaan kesehatan mental siswa di SDN Sekarputih 1 Tegalampel Bondowoso yaitu: (a) Agama sebagai pembimbing dalam kehidupan peserta didik. (b) Agama sebagai penolong dalam menghadapi kesulitan untuk memecahakan masalah yang di alami siswa. (c) Agama sebagai penentram bathin. (2) Peran PAI dalam pembinaan kesehatan intelektual/kesehatan pikiran di SDN Sekarputih 1 Tegalampel Bondowoso yaitu: (a) Guru membimbing peserta didik secara akademis di dalam sekolah maupun di luar sekolah. (b) Kajian-kajian keagamaan oleh guru PAI sebelum atau sesudah mata pelajaran dimulai. (c) Membudayakan siswa untuh silaturrahim kerumah guru. (d) Bimbingan secara intelektual kepada dengan teori-teori keagamaan yang memadai, agar siswa tidak sekuler dalam berperilaku sehari-hari.

Educare: journal of primary education

Air pollution is a major health problem in developing countries and has adverse effects on human health and the environment. Non-thermal plasma is an effective air pollution treatment technology. In this research, the performance of a dielectric barrier discharge (DBD) plasma reactor packed with glass and ceramic pellets was evaluated in the removal of SO2 as a major air pollutant from air in ambient temperature. The response surface methodology was used to evaluate the effect of three key parameters (concentration of gas, gas flow rate, and voltage) as well as their simultaneous effects and interactions on the SO2 removal process. Reduced cubic models were derived to predict the SO2 removal efficiency (RE) and energy yield (EY). Analysis of variance results showed that the packed-bed reactors (PBRs) studied were more energy efficient and had a high SO2 RE which was at least four times more than that of the non-packed reactor. Moreover, the results showed that the performance of ceramic pellets was better than that of glass pellets in PBRs. This may be due to the porous surface of ceramic pellets which allows the formation of microdischarges in the fine cavities of a porous surface when placed in a plasma discharge zone. The maximum SO2 RE and EY were obtained at 94% and 0.81 g kWh−1, respectively under the optimal conditions of a concentration of gas of 750 ppm, a gas flow rate of 2 l min−1, and a voltage of 18 kV, which were achieved by the DBD plasma packed with ceramic pellets. Finally, the results of the model's predictions and the experiments showed good agreement.

Niloofar