Situs inversus totalis (SIT) is a rare birth defect marked by a complete reversal of the positions of abdominal and thoracic organs, resembling a mirrored image. This condition can raise challenges both in diagnosis and treatment procedures. Management of cholelithiasis in SIT patients presents difficulties due to the anatomical differences. We present a case involving a 47-year-old male patient who experienced intermittent left upper abdominal pain over the course of 4 months; the pain had worsened in the last 2 months. The pain was felt radiating to the waist and left back and was accompanied by nausea and vomiting. After clinical assessment and radiological investigations, such as thoracic X-ray and abdominal ultrasound, the patient was suspected of having cholelithiasis and SIT. The patient underwent an elective laparoscopic cholecystectomy without complications and experienced an uneventful recovery. Several intraoperative adjustments were implemented to address the technical challenges arising from the underlying anatomical variation.

Karishma

Thrombocytopenia is a recurrent hematological disturbance in pregnancy. In pregnant women with thrombocytopenia, the risk of excessive bleeding during or after child-birth is high, particularly when they require a cesarean section, other surgery during pregnancy, labor or in the puerperium period. The objective of this study was to assess the prevalence of thrombocytopenia among pregnant women attending antenatal care service at Tripoli University Hospital, Libya. A cross-sectional analysis was used to determine the prevalence thrombocytopenia in pregnant women attending prenatal care services from July to December, 2020 at Tripoli University Hospital. A structured pretested questionnaire was used to obtain socio-demographic data, nutritional factors, obstetrics and gynecological factors, history and clinical conditions. Venous blood samples were collected for platelet count and other platelet parameters, which determined by using Sysmex automation. A total of 72 participated women; about 40%, 35% and 259% of the participants were in the third, second and first trimester, respectively. The mean number of children that women have was 2, with 2.7% having just one child and 47% having three or more children. This study concluded that the prevalence of thrombocytopenia and mostly with mild form is 8.3% and as being greater among pregnant women living in rural areas. Health care providers should do thrombocytopenia test regularly for every pregnant woman in order to prevent excessive bleeding during pregnancy, especially whom living in rural areas.

Mediterranean journal of pharmacy and pharmaceutical sciences

Computer as a revolution left no area of life untouched in the present world. It is of tremendous help in all field of life. Hence, the knowledge of computer is a necessity for existence of everybody in this global village. The invention of computer has transformed our simple manual works to sophisticated life of automated works to meet the global demand for the higher productivity and increased efficiency with high precision. Computer is increasingly becoming compulsory in nearly all fields of studies, not because of anything but its accuracy and versatility in processing data. Many tasks at home or office are being automated rapidly with computer. Thus it is becoming apparent that in whatever discipline or working sector, the computer is now a very vital tool for efficiency improvement and precision of job or task execution. This is designed to meet the prerequisite need of everybody that are interested and wish to know about computers science and computing in general. A computer is an electronic device, operating under the control of instructions stored in its own memory. These instructions tell the achine what to do. The computer is capable of accepting data (input), processing data arithmetically and logically, producing output from the processing, and storing the results for future use. Most computers that sit on a desktop are called Personal Computers (PCs). The "computer" is an ensemble of different machines that you will be using to get your job done. A computer is primarily made of the Central Processing Unit (usually referred to as the computer), the monitor, the keyboard, and the mouse. Other pieces of hardware are commonly referred to as peripherals. In everyday life activities, we process data or encounter cases of data processing. A typical example of data processing is the generation of statement of student result from the marks score in an examination and continuous assessment. It is essential to know that information is as good as the data from which it is derived, and the transformation process which they are subjected to. Meaningless data or inappropriate processing produces wrong information. Thus computer gives you results corresponding to what data you supply and how you process it (i.e. ëgabbage- in, gabbage-outí) Summarily, the intelligent performance of a computer depends on correctness of input data and the intelligence performance of the human being that drives it.

Kamal singh

Background: Hypertension (HTN) is defined as a blood pressure (BP) ≥140/90 mm Hg. The prevalence and mortality from HTN, globally and locally, have been on the increase since the 1980s. This study aimed to detect young adults (18-40 years) in Enugu State who are hypertensive, in order to raise the awareness that HTN is also common in young adults. Its early diagnosis and management could help to reverse the trend in the number of cases of HTN in Nigeria which had been predicted could hit 39.1 million by 2030 if the present trend is allowed to continue. Methods: Participants were administered with structured questionnaire. Their BPs, heights and weights were measured using sphygmomanometer, stadiometer and scale balance respectively. Data were analyzed as proportions, Pearson product moment correlations and Chi square tests using MaxStat (version 3.60) statistical software. Results: The overall prevalence of HTN was 21.3%; 20.7% in the 18-29 years age group; 25.9% in the 30-40 years age group; 24.3%, in males; and 20.3% in females. Pearson product moment correlation coefficient r between age and HTN=0.462, between sex and HTN=0.328, between family history and HTN = 0.513, between salt intake and HTN=0.613, between BMI and HTN=0.152, between physical activity and HTN=0.293, between smoking and HTN=0.308. Conclusions: HTN in young adults is more common than previously thought and if unmanaged in early life usually progresses to HTN later in life.

Emmanuel umegbolu

Medicinal plants have been known for thousands of years and are highly esteemed worldwide as a rich source of therapeutic agents for preventing and curing diseases. Nowadays, a large number of the population suffers from gallstones. The gall stones problem is increasing significantly due to changes in living styles and conditions, i.e. industrialization and malnutrition. Medicinal plants have been used for centuries due to their cultural acceptability, efficacy, safety and lesser side effects than synthetic drugs. The review aims to gather information on the plants utilized in various parts of society against gallstones. The information is useful for ordinary people and the scientific community to carry out further phytochemical, pharmacological and toxicological studies to discover new, effective and safer molecules against gallstones.

Dr. salman ahmed

Overpopulation is a global problem which affects almost everyone in the globe by reducing the available natural resources in the existence. An epidemiological survey was conducted with the aim to assess the people’s response towards overpopulation and its harms to them. The study was conducted based upon descriptive survey design using interview method. The study comprises 80 people residing in selected rural area. The data was collected based on purposive sampling using checklist. The study reveals that most of the people are residing by doing unskilled work due to unemployment with poor living standard.

Neeraj kumar bansal

“Phyllanthus emblica” known to be amla has role in the skin aging influences the changes in skin, including skin dryness, wrinkle, and irregular pigmentation. Initially the 6 day observation has been taken for the ageing activity to be track to study the TREM2 pathway of “Phyllanthus emblica”. Cellular observation and pathway consideration: The environmental impact of pH, Temperature, Humidity and stability of amla fruits is important for the ageing of cells in neuronal cascade of TREM2 Pathway, while studying the fruits cell cycle. The melanin suppression through inhibition of tyrosinase and tyrosinase-related protein-2 activities, the strong antioxidant, and the potent matrix metalloproteinase-2 in cellular observation of tyrosinase pathway. The study aimed to evaluate the anti-skin aging efficacy of amla.

Dr. wahul umesh b

Dermatophytes and Candida albicans are widespread with increasing prevalence and pose a grave threat to public health globally. Ocimum gratissimum and Mitracarpus scaber have been used in Southeastern Nigeria for several purposes, including antimicrobial effects, and have exhibited inhibition of growth to fungi. This study aimed to evaluate and ascertain the antifungal potential of these extracts against dermatophytes and Candida albicans. A total of 50 samples of dermatophytes and Candida albicans previously isolated from clinical samples at two different Hospitals, in the Southeast of Nigeria were used. The clinical samples were vaginal discharge, sputum, swab samples from the endocervix, urine, groin, mouth thrush, and palm. These organisms were all identified using standard mycological identification and characterization techniques. The sensitivity of selected fungi to the extracts (ethanolic extract of M. scaber and O. gratissimum oil) and ketoconazole was evaluated using a modified cup-agar diffusion plate method. The minimum inhibitory concentration (MIC) of the extracts was determined by the agar dilution method. Their minimum fungicidal concentration (MFC) and killing rates against the isolates were also determined. The organisms remain an important etiological agent in this species, implicated in several kinds of infections. The result showed that the activity of the O. gratissimum oil was comparable with that of the conventional drugs, indicating the potential in this extract. The MIC values for Candida isolates were consistently lower against O. gratisimum compared to ketoconazole. The MFC results indicated that O. gratissimum oil had a greater biocidal effect against most of the test organisms in contrast to ketoconazole. The killing rate study also indicated that the oil has very good activity against the isolates. O. gratissimum oil holds great potential for use in treating a wider spectrum of fungal pathogens.

Mediterranean journal of pharmacy and pharmaceutical sciences

The propagation of using drugs on the road was the main reason for focusing on the development of the rapid methods which are used to detect the presence of drugs which may have been taken. Oral fluid has become a popular specimen to test for the presence of drugs. In vitro tongues were prepared with different concentrations of hydroxypropyl methyl cellulose (HPMC E4M); one of these concentrations was chosen to be used for tests. Chemical reagents were prepared which included: cobalt thiocyanate, fast blue B test, Marquis, Mandelin and Zimmerman reagents which were used to examine eight drugs in three different concentrations, each of 10.0 mg/mL, 05.0 mg/mL and 01.0 mg/mL where each reagent was used for a particular drug. The drugs were amphetamine, cannabis, cocaine, 3,4-methylenedioxymethamphetamine (MDMA), codeine, diazepam, heroin, methadone and morphine. Each drug was tested by a specific reagent. The difference in the concentrations gave various results in terms of achieving positive results and the ratio of the clarity of the colour. The amount of the drug on the tongue was between 20 μg and 400 μg. Positive and negative results were obtained in this study. Most of the high concentrations gave positive results; however, the low concentrations gave different results which were between positive, negative and light or very light in colour. In conclusion, there is an explanation of the difference in sensitivity of the effects of the different kinds of reagents in the drug, such as cobalt thiocyanate which was more sensitive at the low concentration of heroin and gave a clear result.

Mediterranean journal of pharmacy and pharmaceutical sciences

This document will discuss some crucial operational aspect to the National Agricultural Development Company (NADEC) https://nadec.com.sa/ dairy Milk production company such as how well the inventories within the production system are currently managed, detailed illustration of the critical operations involved within NADEC production system presenting a logical operational flow, identify the two points where the organisation’s delivery system may fail to align its operational performance measures, how a lean approach could be utilised in the production system to reduce the failings potentially and the three key findings discussing the extent to which the lean approach may assist the production system with aligning its operational performance measures

Mohamed sorogy

Industry 5.0 is still a developing concept, but it is expected to leverage a range of advanced technologies to facilitate human-machine collaboration and enable more customized and sustainable manufacturing.This research paper tried to discuss the opportunities and challenges in the implementation of Industry 5.0. It primarily explored the need to transform from Industry 4.0 to Industry 5.0. The research paper further studied the technologies needed for the implementation on Industry 5.0 and also the principles of Industry 5.0.

Dr. kishor bholane

Potato starch extraction is a critical process with implications across various industries, including food, pharmaceuticals, and bioplastics. This review explores current techniques, challenges, and future opportunities in potato starch extraction. Traditional methods such as compression or wet grinding, enzymatic processes, and microwave-assisted extraction are examined for their efficiency, advantages, and limitations. The paper emphasizes the importance of quality control measures to ensure the purity and safety of the extracted starch. Critical quality control aspects include raw material inspection, monitoring during processing, purity and composition analysis, and adherence to national and international standards. Innovations in extraction methods, including enzymatic and green solvent extraction, ultrasonic and microwave-assisted techniques, and advancements in nanotechnology and biotechnological approaches, are highlighted as trends driving the industry towards greater sustainability and efficiency. The clean label movement also reflects a consumer-driven shift towards natural, minimally processed ingredients, influencing industry practices and regulatory compliance. The future of potato starch extraction holds significant promise, with the integration of sustainable practices and technological innovations to meet evolving market demands and regulatory standards, underscoring the need for continuous research and development in the field.

Dr. salman ahmed

Introduction: Loco-regional anesthesia role is increasingly important in surgery, especially in postoperative pain control. Using ultrasound-guided techniques has made the loco-regional approach increasingly safe and manageable, guaranteeing excellent analgesic results and patient compliance. This bibliometric research aimed to identify the most influential papers on the adductor canal blocks and outline their characteristics. Methods: All articles published from 1980 to 2022 were included in the Web of Science, PubMed, and Scopus databases and found using the keywords “Adductor canal block” or “Saphenous nerve block” or “Peripheral nerve block” or “Hunter canal block” or “Subsartorial canal block” or “ACB” or “Knee” or “TKR” or “TKA” or “Analgesia” or “Arthroplasty” or “Replacement” in the title section had bibliometric analysis performed. The first 25 papers were selected and analyzed by the number of citations. The correlation between numerical variables was evaluated using the Pearson Correlation coefficient. Results: Literature screening found 252 publications. One hundred ten were only about the adductor canal block. Of these, 25 articles were selected for our bibliometric study, published in 8 different journals and with a total number of citations equal to 1.457. “Regional Anesthesia and pain medicine” journal – with 9 articles – was the one that produced the most. There was a significant strong correlation between the n. of citations and the citation rate (R = 0.84, p < 0.001). Conclusion: The purpose of this study is to be a guide on regional anesthesia and, particularly, on adductor canal block, making the most effective as well as the most cited articles available to anesthesiologists or other researchers interested in this topic.

Dario cirillo

The main objective of this study is to examine the relationship between globalization, resource conflicts and peace –building in Africa, with particular emphasis on Nigerian’s north-central geo-political zone. The wave of globalization that has swept across the world with its attendant socio-economic and political consequences lies at the heart of this study. The debate that is raging currently amongst intelligentsias, public analysts, and the international community point to the fact that the global system has suffered increasing setbacks occasioned by the impacts of globalization and contestation for scarce natural resource endowments. The changes that have emerged for several decades in both developed and developing nations, with the latter having a greater share of repercussions, have remained largely daunting. The multiplier effects of these changes have resulted in worsening crisis situations, with a fast growth rate of intra-state and/or trans-regionalized networked conflicts, which is why Africa and indeed Nigeria, has become a hotbed for contestations recently. This work adopts a qualitative approach as a method of investigation. This work relies on classic works of experts in the broader discipline of globalization and conflict resolutions, the essence of which is to clearly define ways of ensuring absolute peace in Nigeria’s north-central zone. The paper observes that guaranteeing peace-building requires the adoption of both vertical and horizontal approaches as templates for the realization of peace objectives.

Canice erunke

Menstruation is a normal physiological impact on each girl’s life. Menstruation is monthly uterine bleeding for 3-5 days after every 28 days from puberty till menopause. A change in mood, behaviour, appearance of some abnormal vague symptoms is often noticed in the second half of the cycle. Symptoms are severe enough to disturb the life cycle of a woman called premenstrual syndrome (PMS). The study aimed to assess the premenstrual symptoms and coping strategies among adolescent girls. The majority of the students suffered from premenstrual syndrome. Objective: to assess the premenstrual symptoms and coping strategies among adolescent girls. Methodology: A nonexperimental descriptive research design was adopted in this study. Non probability convenient sampling technique was used to select the sample size of 30 adolescent girls. The assessment of premenstrual symptoms and coping strategies was carried out using a self-reported Likert’s rating scale. Data was analyzed by using descriptive and inferential statistics. Result: Majority (93.3%) of the samples sometimes had physiological and psychological problems, 90% of them had behavioural symptoms. Majority (43.3%) of the samples always followed coping strategies and 16.7% of the samples sometimes followed coping strategies and 40% never followed any coping strategies. Conclusion: PMS was common among students at 18-24 years. The most common physical symptoms experienced by adolescent girls were headache, backache and lower abdominal pain. Adolescent girls used coping strategies as taking hot / cold drinks, do not express anger to others, and turn to study and forget things, hearing music and taking medications. Keywords: Premenstrual Symptoms, physiological, psychological & behavioural symptoms, Coping Strategies, Adolescent Girls.

Elsi queen

The current study was conducted to explore the antiemetic activity of ten aromatic medicinal plants viz., Carissa carandus L. (fruits), Chichorium intybus L (flowers), Cinnamum tamala L (leaves), Curcuma caesia Roxb (rhizomes), Lallemantia royleana Benth (leaves), Matricaria chamomila L (flowers), Piper longum L (fruits), Piper methysticum G. Forst (fruits), Piper nigrum Linn. (fruits) and Syzygium aromaticum (Linn.) Merr. & Perry (flowering buds) was studied using a chick emetic model. The ethanol extracts of these plants were administered at 150 mg/kg body weight orally. Domperidone was given at 100 mg/kg as a reference drug. All the extracts decrease in retches induced by copper sulphate pentahydrate given orally at 50 mg/kg body weight and showed comparable antiemetic activity with domperidone. Compound targeted antiemetic activity is further suggested. Aromatic plants have tendency to relief from nausea. Alpinea offinarum,Zingiber officinale, Mentha piperita, Menthaspicata and Lavandula angustifola,are aromatic plants reported to possess antiemetic activity. So, presentinvestigation was done to evaluate more aromatic plantsregarding their antiemetic activity. Results of the antiemeticactivity of the ethanol extracts of Carissa carandus,Chichorium intybus, Cinnamum tamala, Curcuma caesia,Lallemantia royleana, Matricaria chamomila, Piper longum, Piper methysticum, Piper nigrum and Syzygium aromaticum are shown in the Table. All the extracts showed antiemeticactivity comparable with domperidone. The % inhibition was recorded as Carissa carandus (68.29), Chichorium intybus (73.86), Curcuma caesia (89.97), Cinnamum tamala (70.64), Lallemantia royleana (83.61), Matricaria chamomila (59.92), Piper longum (81.65), Piper methysticum (80.03), Piper nigrum (89.48) and Syzygium aromaticum (87.81). The highest % inhibition was shown by Curcuma caesia (89.97) and the lowest by Matricaria chamomila (59.92), whereas domperidone showed 80.18 % inhibition of emesis.

Dr. salman ahmed

Metformin is considered the first-line treatment as a monotherapy for patients with type 2 diabetes mellitus. Emerging evidence suggests that metformin may have a renoprotective role; therefore, understanding the impact of metformin dose and therapy duration on renal function may significantly improve renal outcomes in type 2 diabetes patients. This study aims to investigate the renoprotective effects of metformin by analyzing its dose-dependent impacts on the estimated glomerular filtration rate in patients with type 2 diabetes mellitus. A retrospective cross-sectional study design was used from September 2022 to October 2023. Data from 302 type 2 diabetes patients were collected from patient files at the Benghazi Diabetic Center and the Aljabal Al-Alkdar Diabetic Center, including all with type 2 diabetes mellitus patients on varying doses of metformin. The collected data included age, gender, metformin dose, duration of metformin therapy, urea, and creatinine. Exclusion criteria included patients with significant comorbidities such as chronic kidney disease (other than diabetic nephropathy), liver disease, heart failure, or malignancy; those taking nephrotoxic medications; individuals with recent acute illnesses or surgical procedures; pregnant or lactating women; participants with inadequate medical records; and patients who were non-adherent to metformin therapy. Survival analysis was conducted to evaluate the effect of different metformin doses on the estimated glomerular filtration rate. The study analyzed 302 diabetic patients, of whom 46.0% were male and 54.0% were female. The age was 58.3±11.9 years. The HbA1c was 7.7%±1.3%. The duration of diabetes was 11.4±8.1 years. The creatinine was 1.0±0.9 mg/dL, and the urea was 36.7±23.8 mg/dL. Data analysis revealed a statistically significant difference in survival distribution across the dose groups. Different metformin doses significantly impact the estimated glomerular filtration rate, suggesting that dosage plays a crucial role in maintaining renal function.

Mediterranean journal of pharmacy and pharmaceutical sciences

In the Indo-Pak subcontinent, the traditional systems of medicine, both Ayurvedic and Unani, are primarily based on herbs and herb-based preparation for therapy. Therefore, the importance of the herbal identification process remains critical in achieving the desired and successful therapeutic effect. To support the manufacturers and practitioners of both systems, many herbs are still collected from wild sources, as herbal farming is not very developed in this part of the world. During a survey program conducted in different areas of Pakistan, significant lacks and gaps were noted to be present in the identification & characterization of herbs, which needs to be addressed and fulfilled as many species look alike apparently or physically but have different biological or pharmacological activity. Based on this objective and approach, Centella asiatica was selected for the pharmacognostic and preliminary phytochemical investigation to establish a better correlation and to provide useful methods in its identification as the use of Centella asiatica is very common in Pakistan and other South Asian countries for CNS disorders therapy. Therefore, this study aimed to develop & report some and rapid identification methods for Centella asiatica. The present study includes physical, physicochemical, preliminary phytochemical and fluorescence analysis. For the first time, in the present study, NIR and FT-IR spectra of Centella asiatica have been reported for identification. The findings of the present study are quite promising and can be helpful for the manufacturers and researchers in the identification and development of Centella asiatica-based new drugs or formulations.

Dr. salman ahmed

Gaucher Disease (GD) is the most common lysosomal storage disorder. The prevalence of GD is approximately 1/100,000, and type III GD accounts for 5% of cases. [1] It is an autosomal recessive disease due to a GBA gene mutation, leading to glucocerebrosidase enzyme deficiency. [1,2] Gaucher disease (GD) is categorized into three types according to clinical presentation: [3] Type I, which is non-neuronopathic and most common, particularly among Ashkenazi Jews; Type II, which is acute neuronopathic and marked by significant neurological involvement and high mortality rates; and Type III, which is subacute neuronopathic, exhibiting both systemic and neurological symptoms. In this report, we discuss a 24-year-old man from Libya diagnosed with GD type III. His diagnosis was established at the age of one due to symptoms including pallor, poor appetite, and hepatosplenomegaly. Laboratory tests indicated a hemoglobin level of 5.6 g/dL, chitotriosidase activity of 18,742 μmol/L, and an angiotensin-converting enzyme level of 251 UI/L. Genetic analysis confirmed a homozygous L444P mutation. He underwent splenectomy at the age of three, and enzyme replacement therapy (ERT) was administered intermittently with regular follow-ups until 2011. In December 2023, the patient experienced two weeks of abdominal pain, distension, and fatigue. A physical examination revealed ascites, dilated abdominal veins, and an enlarged liver and spleen.

Karishma

Object: In the competitive world of the market economy, every economic unit tries organizing everyday activities. Creating a set of suitable and cost-efficient organizational structures and making competitive products and services, top managers should find the mechanisms of building alternative ways of organizational structures. Methods: This paper presents the traditional and modern management structures, their historical steps, and developed methods. In this footfall of the market economy, companies in developing countries should build their management system’s organizational structure. They should advance a management system, managerial behaviours, and new management styles of developed ones. For this purpose in this research has learned organizational structures of developed companies. The investigation discusses the emergence, formation, and modern appearance of management structures that evaluate organizational structures’ importance in enterprises and companies’ activities, using vivid examples. Findings: Then, it has shown some forms of developed organizational structures of companies with the assessment of their highest role in management. In the conclusions and recommendations, we offer our approaches to solving existing organizational problems using the historical period of development to this day.

Ikboljon odashev mashrabjonovich