This review was aimed to describe a new approach of healthcare performance strategy based on individual genetic variants. Personalized medicine is a model for health care which is a combination of preventive, personalized, participatory and predictive measures. It is an approach for a better treatment by identifying the disease causing genomics makeup of an individual. This work features key advancements in the improvement of empowering advances that further the objective of customized and precision medication and the remaining difficulties that, when tended to, may produce phenomenal abilities in acknowledging genuinely individualized patient consideration. Customized treatment for patients determined to have strong tumors has brought about a few advances as of late. To improve a multi-drug approach ready to coordinate DNA and RNA adjustment, proteomics and metabolomics will be essential. The execution of translational examinations dependent on fluid biopsy and organoids or xenografts to assess molecular changes because of clonal weight produced because of the utilization of target specialists or tumor heterogeneity would help in the recognition of systems of opposition, proposing opportunities for novel mixes. The investigation of massive data in oncology can profit altogether from being engaged by artificial intelligence and machine learning strategies.

Mediterranean journal of pharmacy and pharmaceutical sciences

Background: The deliberate postponement of significant academic assignments with due dates is known as academic procrastination. The undesirable habit known as procrastination is the inability to start or finish a task within the allotted time, which results in detrimental effects on students' future employment, as well as stress, guilt, poor academic achievement, and low self-esteem. Method: Descriptive Research design was adopted for a study to assess the Variables influencing Nursing students' Academic Procrastination at selected Nursing college of Bhopal, M.P. Sample size 60 B.Sc. Nursing students. Result: Result revealed that majority of students were females, 27 out of 60 were in age group of 20-21yeras, 25 (41.6%) were studying in B.Sc. N 3rd year. Most of students resided in Rural area (36), 54 out of 60 belong to nuclear family and 35 mothers of students were educated as compared to 51 fathers. The mean score and SD of influencing variables of academic procrastination were as follows Personal variable was 2.6 ± 0.48, Environmental 2.26 ± 0.71, and Academic was 1.78 ± 0.41. Majority of nursing students 39 (65%) were moderately affected by Personal variables, Environmental variables affected 23 (38%) students moderately and academic variables affected 17 (28%) students moderately. Only Personal factor had more effect on 5 students as compared to none in other two variables. Conclusion: The study concluded that Environmental and personal factor had more effect on Academic procrastination as compared to academic variables.

Dr k c yadav

Oecophylla longinoda has some reported medicinal uses, including antimicrobial, analgesic, and anti-inflammatory activities. This study was designed to investigate the Oecophylla longinoda methanol extract to evaluate the toxicity profiles of its acute and sub-acute effects. The experiments were conducted to determine the oral median lethal dose (LD50) and other gross toxicological manifestations on an acute basis. In the first phase of the acute toxicity study, three per group were administered Oecophylla longinoda at single oral doses of 10, 100, and 1000 mg/kg body weight, and 1600, 2900, and 5000 mg/kg of Oecophylla longinoda in the second phase. In the sub-acute studies, the mice were orally administered 2.5 g/kg Oecophylla longinoda per day for 14 consecutive days. Rat body weight and fluid intake were recorded during the 14 days. The rat kidney, heart, liver, and blood sera were obtained for weight, histological, and biochemical markers including glucose, cholesterol, proteins, triglycerides, enzymes including ALT, AST, and ALP, as well as electrolytes (sodium and potassium) examinations. Results show that the methanol extract of Oecophylla longinoda is safe, and no significant changes in the biochemical markers that indicate harmful effects on the kidney and liver were observed in mice. However, the liver showed slight changes while the kidneys and heart remained healthy in mice exposed to Oecophylla longinoda. The no-observed-adverse-effect limit was 5000 mg/Kg body weight/day.

Mediterranean journal of pharmacy and pharmaceutical sciences

The present study focused on analysing the impact of ‘Make in India’ campaign on FDI inflows in country. The research period is divided in two parts one is pre ‘MII’ & another is post ‘MII’ period. The analysis of ‘Make in India’ campaign is done to identify the scope of the campaign & methodology of working of various allied departments monitoring campaign. The present research work also attempted to take overview of various policy reforms initiated by Government of India to promote the FDI as well domestic investment in 25 sectors shortlisted under MII. The FDI inflows statistics reveals that, the post MII period is showing the highest growth in FDI equity inflows as compare to same period i.e. 2009- 2014. The MII initiative is one of the reason for the jump in FDI inflows. The overview of policy reforms shows that GOI through DIPP attempted to open almost all sectors for 100% FDI through automatic route. Government has provided multiple incentives for Foreign Investors to establish their manufacturing facilities in country but very negligible response has been seen in the nature of FDI equity inflows in the same period. Further results of study reveals that multiple ‘MOU’s have been signed by States & Central Governments, but they yet not converted in actual investments. The major reasons behind the same is lack of SWOT analysis through Governments before inviting the foreign investors. As well lack of basic infrastructure, land, lack of skilled manpower, cheap & un interrupted power supply to MIDC’s & SEZ’s is yet not successfully provided, lower rankings in Ease Of Doing Business (EODB), Global Manufacturing Competitiveness Index (GMCI) is also cause of concern & tumbling block in the success of MII mission..

Anshuman vijay magar

Objective: To determine the association between oral health literacy, oral hygiene and gingival health status. Methods: This cross-sectional study was conducted among patients attending University of Benin Teaching Hospital, Benin City. Data were collected through interviewer-administered questionnaires. Index used in this study for estimating oral health literacy levels was Rapid Estimate of Adult Literacy in Dentistry- 30 (REALD-30). The participant’s oral hygiene status was assessed using the Simplified Oral Hygiene Index while gingival health was assessed using the Gingival Index. Results: Two hundred and eight participants with 130 (62.5%) males and 78 (37.5%) females formed the population of the study and their mean age was 28.32 ± 10.5 years. The prevalence of low oral health literacy was 86 (41.3%). The oral hygiene status of most of the participants 100 (48.1) was fair. The prevalence of gingivitis was 58.2%. Oral health literacy had significant statistical negative correlation with age, oral hygiene and gingival health status. Oral health literacy consistently emerged as a predictor of oral hygiene and gingival health status. Conclusion: Majority of the participants with low oral health literacy had fair/poor oral hygiene status (p = 0.000, OR= 17.870, 95% CI = 7.320-43.627) and gingivitis (p = 0.000, OR= 7.054, 95% CI = 3.514-14.164).

Hope inegbenosun

Writing is a complex skill and is difficult for students to master well. This study aims to determine the effect of the application of Think Talk Write learning models with poster media on the writing skills of persuasion essay from fifth grade elementary school students. This type of research is a quasi-experimental design with a pre-test post-test control group. The sample in this study was VA and V class students of SDN Rambigundam 01 Jember. Collecting data in this study using interviews, tests, and documentation. The data analysis technique of student learning outcomes uses t-test. Based on the results of the t-test on the learning outcomes of students' persuasive essay writing skills, it is known that the value of tcount> ttable, (2.208> 2.0180), so it can be concluded that the hypothesis is accepted that the Think Talk Write learning model through poster media influences the writing skills of persuasion writing in the fifth grade students of SDN Rambigundam Jember 1. The results of the pretest and posttest activities also showed that the increase in the value of writing skills written by students in the experimental class was higher than the increase experienced by the control class. Difference in the increase in the average value experienced by the experimental class and control class by 3,7. Menulis merupakan salah satu keterampilan yang kompleks dan sulit dikuasai siswa dengan baik. Penelitian ini bertujuan untuk mengetahui pengaruh penerapan model pembelajaran Think Talk Writedengan media poster terhadap keterampilan menulis karangan persuasi siswa kelas V SD. Jenis penelitian ini merupakan eksperimen semu dengan desainpre-test post-test control group. Sampel dalam penelitian ini adalah siswa kelas VA dan V B SDN Rambigundam 01 Jember. Pengumpulan data dalam penelitian ini menggunakan metode wawancara, tes, dan dokumentasi. Teknik analisisdata hasil belajar siswa menggunakan uji t-test. Berdasarkan hasil uji-t terhadap hasil belajar keterampilan menulis karangan persuasif siswa, diketahui bahwa nilai thitung>ttabel, (2,208>2,0180), sehingga dapat disimpulkan bahwa hipotesis diterima yaitu model pembelajaran Think Talk Write melalui media poster berpengaruh terhadap keterampilan menulis karangan persuasi pada siswa kelas V SDN Rambigundam 01 Jember. Hasil kegiatan pretest dan posttest juga menunjukan bahwa peningkatan nilai keterampilan menulis karangan siswa di kelas eksperimen lebih tinggi dari pada peningkatan yang dialami kelas kontrol. Selisih peningkatan rata-rata nilai yang dialami kelas eksperimen dan kelas kontrol sebesar 3,7.

Educare: journal of primary education

Micro-level assessment of vulnerability to climate change creates basis for policy formulation. The study specifically ascertained the levels and determinants of vulnerability to climate change among selected food crop farmers. Data collected were analysed using descriptive statistics and ordinary least square regression analysis. The result revealed that 15.95%, 68.97% and 15.08% of the households were highly vulnerable, moderately vulnerable and less vulnerable to climate change respectively. This implies a varied effect on crop farmers. The result also showed that amount saved, extension contacts, household expenditure and value of crop were significant at 1% level. The study recommended the provision of basic amenities and soft loans to farmers as well as an improvement in extension services. It also advocated the introduction of effective climate change mitigation and adaptive measures to boost agricultural output in their area.

Comfort chikezie

The present study reveals that the enriched aerobic cultures of indigenous microbes can be used successfully for decolorizing dye effluents. Physico-chemical analysis of dye effluent revealed high load of pollution indicators. Textile dye effluent and contaminated soils were collected and analyzed for selection of suitable bacteria for dye degradation. The residual bacterial load was found to be in the range of 108 cfu/mL. Six bacterial strains viz., two species of Bacillus, two species of Klebsiella,, one species each of Planococcus and Micrococcus luteus were isolated. The best two dye degraders namely species of Planococcus and Bacillus were further optimized for the effect of carbon and nitrogen source, pH, temperature and percentage of inoculum. The optimized conditions for both the isolates of Planococcus sp. and Bacillus sp. were used in bio-decolorization studies of textile effluent. More than 50% of decolorization was achieved within 4 d of incubation. After 6 d of incubation, decolorization was achieved above 80%. The isolates Planococcus sp. and Bacillus sp. exhibited maximum decolorization ability at pH between 5-8 and temperature 37C. Moreover, 10% (v/v) inoculums, glucose and peptone as carbon and nitrogen sources were found to be the optimum for decolorization. Both the isolates showed highest decolorization percentage of Coractive Blue 3R dye effectively during optimization and more interestingly showed consistent decolorization of textile dye throughout the study.

Dr. saranya devi k

Brilliant Grid is intended to incorporate progressed correspondence/organizing innovations into electrical power frameworks to make them ''more intelligent''. The current circumstance is that a large portion of the power outages and voltage lists could be forestalled in the event that we have better and quicker specialized gadgets and advancements for the electrical matrix. To make the flow electrical force lattice a Smart Grid, the plan and execution of another correspondence framework for the lattice are two significant fields of examination. Be that as it may, Brilliant Grid projects have just been proposed as of late and a couple of recommendations for forward-looking necessities and starting exploration work have been offered in this field. No efficient audits of correspondence/organizing in Smart Grids have been led at this point. In this manner, we direct an orderly survey of correspondence/organizing innovations in Smart Grid in this paper, including correspondence/organizing engineering, distinctive correspondence innovations that would be utilized into this design, nature of administration (QoS), upgrading the use of resources, control and the board, and so forth.

Dr.a.shaji george

n India, the education sector has been always attentive to adopt innovations and techniques in the teaching-learning process due to various challenges. But nowadays, academic institutions are becoming flexible in accepting the new teaching and learning techniques to satisfy the student sector which as cited as the most vital entity in the educational sector. New technologies, tools, and techniques are proving as a boom for innovative teaching and learning practices. One of the emerging teaching technique is Blended learning which is a process refers to “mixing of the different learning environment for educational transfer”. It combines the traditional face to face classroom method with online learning method supported by advanced technology and tools. Blended learning should be viewed not only as a temporal construct but also as a fundamental redesign model. Through this content, delivery becomes digital and online. Truly blended learning requires teachers should adopt the approach as guides and mentors and learning should go beyond the classroom walls. Blended learning is also known as Hybrid learning. Although, Indian Government is taking initiatives to implement a blending learning approach yet there is a need to access the behavioral aspect of the students to use this blending learning approach. Adopting a blended learning approach must start with a re-examination of the intended learning outcomes.The deployment of cloud in the blended learning process makes its existence more strong. This study is the review of literature selected to identify the need for blended learning deploy with cloud in the teaching-learning process in the Higher Education Sector.

Inderbir kaur

Service quality is a key factor for success in any hotel. Many researchers have conducted studies on service quality, but only a few studies have been conducted on internal service quality (ISQ) in general, and in the hotel industry in particular. Since there is no general agreement among researchers on the measurement of ISQ, many studies have used SERVQUAL instrument to measure the employees’ perceptions of ISQ. The purpose of this study is to explore the influence of ISQ on employee’s job satisfaction in five-star hotels in Jordan. The current study was carried out by measuring the data gathered through a seven-point Likert scale. The quantitative survey method was applied, and therefore the SERVQUAL instrument was used to measure ISQ, and the Job Satisfaction Survey (JSS) was used to measure job satisfaction. Data obtained from a sample of 238 respondents drawn from 14 five-star hotels in Jordan were analysed with the SPSS software based on descriptive statistics. The study’s findings indicated that the ISQ of five-star hotels in Jordan has a significantly positive influence on an employee’s job satisfaction. These findings support the hypothesis that there is a positive relationship between ISQ in the hotel industry and industry employees’ job satisfaction.

Mukhles m. al-ababneh

Abstract should be times new roman with 9 fount single spacing.The main focused of Watermarking is developing and i Image Recognition is the idea of simulating the visual functions of human brain which uses human eyes as the source of input to recognize and make decisions on the objects it sees. This became possible with the advent of cameras and advanced processing technologies. The idea is to copy the features exactly present in the pattern, that the brain uses to recognize images [6]. The image in the real world are captured and pre-processed in the desired format and stored in large chunks of memories. This is to provide the recognition program to compare the new image taken with the ones that has been pre-processed and stored. The comparison is done at the pixel level of the image which is expressed in a matrix form. The image is compared with the data set stored at pixel level and the decisions are made recognizing the image. This picture recognition method becomes a smarter solution with the availability of more number of data sets. With large number of trail and errors the system will get familiar and intelligent providing best solution for computer and robot vision technologies.

Dr h shaheen

Before the start of the SARS-CoV-2 (COVID-19) pandemic, the whole environment around us had been deemed very toxic to breathe in due to the amount of greenhouse gases that had been emitted over the centuries. The Earth faced rising temperatures, which in turn led to the melting of glaciers and rising of sea levels. Environmental degradation was happening fast due to the depletion of resources such as air, water and soil. But after the coronavirus lockdown (Talabandi) commenced, there have been changes in the environment. The lockdown still has a huge impact on people in India too. The halt of industrial production and traffic resulted in cleaner air and rivers. In India the first phase of the nationwide lockdown that began on March 24 followed by enforcement of a series of regulations had some evidences that the COVID-19 curve is flattening in the country's COVID-19 affected regions. There was a good chance Prime Minister Narendra Modi extended the lockdown (Talabandi) four times that ended on (Phase 1 (24 March-14 April)., Phase 2 (15 April-3 May)., Phase 3 (4 May-17 May) & Phase 4 (18 May-31 May). The paper focuses on different aspects of environmental impact due to SARS-CoV-2 in India.

Rina kumari

Ketorolac tromethamine, the non-steroidal anti-inflammatory drug, was formulated into mucoadhesive films to overcome the limitations in the currently available dosage and routes of administration which in sequence will increase patients’ compliance. Films were cast from organic and aqueous solvents using various bioadhesive polymers namely: HPMC E-15, Eudragit RLPO, Eudragit RSPO, Carbopol 934P. The prepared films were subjected to investigation for their physical and mechanical properties, swelling behaviors, in vitro bioadhesion, drug permeation via bovine buccal mucosa, and in vitro drug release. These properties were found to vary significantly depending on the preparation methods, the type of the polymers, and the ratio of addition of both plasticizers (i.e. polyethylene glycol and film forming agent. Formulation F4 is selected for best formulation because it shows the 98.85% drug release at time 6 hr. In addition, this film was subjected to in vitro and in vivo release. The obtained results indicate that the concentration of ketorolac in the oral cavity was maintained above 4.0 µg/ml for a period of at least 6 h. This film shows promising results for using the ketorolac mucoadhesive route of administration topically and systemically, and thus it will be subjected to clinical evaluation in future work.

Kuldeep vinchurkar

Higher Education has an important role in the task of rebuilding a nation and it paves the way for overall development of a nation. The twentieth century has witnessed several revolutions like Green revolution, White revolution, I.T revolution etc; transforming human civilization in to new heights. At the start of 21st century, there is a lot of importance given to higher education. Every country realizes the value of higher education and the benefits accrue from it. There is a greater importance attached to higher education. “The social demands for higher education continue to increase. Indian higher education has a rich and complex history that spans millennia. This abstract provides an overview of the key developments in Indian higher education, highlighting its evolution from ancient times to the modern era. The history of Indian higher education is marked by the establishment of ancient centers of learning, the influence of various empires and dynasties, colonialism, and post-independence reforms. This abstract also touches upon the challenges and opportunities that have shaped the landscape of higher education in India.The history of Indian higher education can be divided into several distinct periods. In ancient India, centers of learning such as Takshashila and Nalanda emerged as renowned seats of knowledge, attracting students and scholars from across the world. These institutions laid the foundation for a tradition of rigorous intellectual inquiry

Dr gedam kamalakar

Background: From the public health point of view, the microbiological properties of domestic water supply are the most important parameters of domestic water supply because of the propensity for microbial water-related diseases. In Enugu State, statistics have shown that reported cases of waterborne diseases (including typhoid fever) have been on the increase since 2003. The aim of the study was to determine the bacteriological qualities of domestic water supply and prevalence of typhoid fever in five communities of Enugu State in connection with the rising incidence of typhoid fever in the state. Methods: This was a cross-sectional study of sources of domestic water supply and prevalence of typhoid fever in five rural communities of Ezeagu Local Government Area. 297 copies of structured questionnaire, 10 grab water samples analysed using the membrane filtration method and 227 blood samples collected for Widal test were used to generate the data for the study, analysed as frequency distributions, t-test of means difference and Pearson product moment correlations using MaxStat (version 3.60) statistical software. Results: 2 (40%) of the 5 communities complied with the WHO standard for faecal coliform counts. Prevalence of typhoid fever was high in all the communities (71.4%-100%). Only faecal coliform counts correlated positively and strongly (r=0.69) with prevalence of typhoid fever. Conclusions: Since faecal coliform counts correlated positively and strongly (r=0.69) with prevalence of typhoid fever, improving the bacteriological qualities of domestic water supply may help to reduce the prevalence of typhoid fever.

Emmanuel umegbolu

Background: In addition to the recent civil war in Yemen, the COVID-19 pandemic resulted in a collapse of the health system, a decline in vaccination coverage, and the spread of numerous outbreaks. In 2022, a measles outbreak impacted Al Dali governorate. This study aimed to describe the demographics of measles patients, measles risk factors, and disease outcomes in Al Dali Governorate, Yemen. Methods: All measles-infected children who sought medical attention at Al Tadhamon Hospital in Al Dali, Yemen, between February and December 2022 were included in this prospective and observational study. Results: During the study period, 154 parents gave their consent to enroll their children in this study; 88 (57.1%) were males, and 66 (42.9%) were females. The mean age of the children was 3.56±2.90 (0.3–12 years). More than half of the mothers (n=88, [57.1%]) were illiterate or had a basic educational level, while most of the fathers (n=126, [81.8%]) were well-educated. Nutritional status was normal in most children (n=146, [94.8%]), and all children were unvaccinated. Most children (n=152, [98.7]) came from areas having measles and most of them (n=130, [84.4]) were in contact with measles cases. Health facilities were close (<3 km) to many children (n=151 [98.1]), and house ventilation was good in 66.2% (n=102) of cases while crowdedness was found in 135 (87.7) cases. Family members were 7 or more in 90 (58.4) cases. Two children under the age of 5 years died because of the disease. Conclusion: Our study showed that the main risk factor for the recent measles outbreak in Al Dali governorate was lack of vaccination, as all involved children were unvaccinated. Routine immunization needs to be reinforced through health centers in different districts and community education about the dangers of the disease and the benefits of the vaccines should be enhanced to prevent outbreaks from recurring.

Karishma

With the emergence of HR Analytics in organizations; gathering, interpreting, and measuring of HR data has become easy. HR Analytics act as a tool which is a combination of statistical techniques that enable collection, interpretation, measurement, and forecasting of data. HR analytics enlightens solution to the organizational problems and make accurate decisions. HR analytics hence aligns HR strategy with overall business strategy to obtain a competitive advantage. HR analytics has passed through phases of measuring the Sub HR functions. HR Analytics provides various opportunities to business as it forecasts workforce requirements, enables HR to achieve corporate goals, and improve organizational performance which helps businesses in finding success. Despite the success, the business faces some big challenges like data governance, skill gap among employees, top management support, and many other such challenges in implementing and using the HR Analytics tool in business. Various research scholars have discussed HR analytics from so many years. So many papers have come focusing on the conceptual part of HR analytics, past present and future scenario of HR analytics, acceptance of HR analytics in organizations, the extent of its utility, rise of HR analytics, and various other related studies. This paper aims to find out the challenges and opportunities faced by the business firm in implementing HR analytics as a tool in organizations. This study also gives the theoretical concept of HR analytics based on secondary data collected from previous research papers, journal of the year 2016- 2019 given by various research scholars, blogs, and websites that provide HR analytics recent data. The study will provide the pros and cons of implementing and using HR analytics.

Mamta gaur

The incorporation of lomustine, a hydrophobic anticancer drug into PLGA nanoparticles by interfacial deposition method was optimized. Based on the optimal parameters, it was found that lomustine-PLGA nanoparticles with acceptable properties could be obtained. Optimization of formulation variables to control the size and drug entrapment efficiency of the prepared nanoparticles seems to be based on the same scientific principles as drug-loaded nanoparticles prepared by nanoprecipitation, solvent evaporation method. The process was the most important factor to control the particle size, while both the drug-polymer interaction and the partition of drug in organic and aqueous phases were the crucial factors to govern the drug entrapment efficiency. PLGA concentration at lower level (100 mg), 1:5 organic phase: aqueous ratio, 1%w/v PVA concentration, 3%w/v pluronic F68 achieved smaller particle size. Additionally, L:G ratio of PLGA 75:25, lower volume of organic solvent (1:10 organic phase: aqueous phase), higher initial drug content (10 mg) enhanced the drug entrapment efficiency and maintained lomustine concentration in blood for an extended time period, elevated lomustine concentration in lungs and slowed the elimination of lomustine. The biodistribution profiles of prepared nanoparticles in albino mice showed higher plasma drug concentration for longer period of time, elevated drug concentration in lungs and slow elimination from kidney. No toxic effects of prepared nanoparticles were observed in histopathological examination of lungs and kidney. The systematic investigation reported here promises the development of PLGA nanoparticles loaded with lomustine when tested in Lung Cancer cell line L132 and toxicological/ histopathological studies in albino mice.

Archana mehrotra

Considering the site (habitat) specific variations in the metabolic activities in the freshwater bivalves, we reported here the changes in the rate of oxygen consumption, rate of ammonia excretion and O: N ratio in the freshwater bivalve mollusc, Lamellidens marginalis (Lamark) from lotic and lentic water habitats on April-May during summer season. The adult freshwater bivalves, Lamellidens marginalis (82-84 mm shell length) from lotic and lentic water near Jayakwadi dam on Godavari river was selected for determination of rate of oxygen consumption, rate of ammonia excretion and O: N ratio. The adult bivalves from lotic water habitat showed high rate of oxygen consumption and low rate of ammonia excretion. The O: N ratio showed higher values in bivalves collected from lotic water than lentic water during summer season. The results of study are discussed in the light of possible physiological processes in freshwater bivalve molluscs.

Dr. pritesh ramanlal gugale