Objectives: Improper and inappropriate use of antibiotics is one of the possible factors affecting the transmission of antibiotic resistance is Because Pseudomonas aeruginosa is one of the most serious pathogenic bacteria in hospital environments and resistant It is an antibiotic that causes problems in treatment. This study aims to determine multiple resistances Pseudomonas has been treated with antibiotics, arsenic and metals. Materials and Methods: In this study, 23 strains of Pseudomonas aeruginosa were isolated from clinical specimens. for review Resistance of these bacteria to penicillin antibiotics was used by Kirby-Bauer method. The minimum concentration C.I.M. (and minimum lethal concentrations (C.B.M.) of antibiotics and heavy metals (cadmium, mercury) and arsenate Tubal dilution, agar and growth were performed in agar plate, respectively. Results: In this study, the highest and lowest MIC values obtained in Pseudomonas aeruginosa for metals, respectively. * 8 and 3 cadmiums (0.6 and 4.9 μg / ml), mercury (<0.12 and 4 μg / ml) and arsenate (10 × were 256 μg / ml). Of 23 strains, 84% to the antibiotic carbonicillin, 63% to piperacillin and 100% to 103 Arsenic and cadmium were resistant. Also, 82.6% of the strains were resistant to mercury. Conclusion: The results of this study showed that Pseudomonas aeruginosa strains have multiple resistance to arsenic, metals and the antibiotics are car penicillin and piperacillin.

Amirhossein jahromi

Systemic onset juvenile idiopathic arthritis (SoJIA) is a rare inflammatory disorder. It is the severest form of juvenile idiopathic arthritis, and complications occur most commonly in this type. Non-responsiveness to standard therapy with corticosteroids and disease-modifying antirheumatic drugs is not uncommon. Interleukin-1 beta (Il-1β) has been shown to be a main contributor to the pathogenesis of SoJIA. Anakinra, a recombinant Il-1β receptor antagonist, was shown to be effective in small cohorts of therapy-resistant adult and pediatric still's patients. This study aimed to evaluate the real-world efficacy, steroid-sparing effect, and safety profile of anakinra in patients with SoJIA at a tertiary care center in Libya. A retrospective case series was conducted on patients with SoJIA treated with anakinra at the Tripoli Children's Hospital between 2010 and 2017. Data on demographic characteristics, disease activity, corticosteroid dosage, concomitant medications, and adverse events were collected at baseline and at 1-, 3-, 6-, and 12-month post-treatment. 13 patients were treated with anakinra with a mean age of 9.4±4.6 years at anakinra initiation and a female-to-male ratio of 2: 1. All patients were on corticosteroids and 92.3% on methotrexate at treatment initiation. The proportion of patients achieving inactive disease (Jadas 10=0) increased over time. A marked steroid-sparing effect was observed: the number of patients requiring high-dose steroids (>0.5 mg/kg/day) decreased from 100% at baseline to 7.6% at 12 months, and 53.8% successfully discontinued corticosteroids entirely. All patients experienced injection site reaction, and macrophage activation syndrome occurred in 15.4% as a side effect after treatment initiation. But no severe infections or fatalities occurred. Reasons for discontinuation included remission (46.1%), drug unavailability (23.0%), inefficacy (15.3%), and side effects (15.3%). Anakinra demonstrated significant efficacy in inducing rapid disease control and reducing corticosteroid dependence in patients with refractory SoJIA, with a manageable safety profile

Mediterranean journal of pharmacy and pharmaceutical sciences

One of the most common situations in the management process is problematic situations or conflicts, where each complex situation or conflict has unique consequences, and neglect to find the best way out of such situations put the leader in a more difficult situation. Especially at a time while COVID-19 is putting the world community in a very difficult situation, difficult to resolve conflicts, universal conflicts, the role of leaders, managers are discussed, problem solutions are proposed through management theory.

Ikboljon odashev mashrabjonovich

Conservation of Biodiversity is an activity must carry out by all individuals in the world to share the benefits derived from biodiversity. It is a critical task to conduct the biodiversity census and conservation (Biodiversity C & C or Biodiversity C2). Throughout the world several Governament and Non-Governamental organizations work together as a unit to maintain our biodiversity in safe mode. India is a mega diverse country with rich biodiversity. The development of modern science and technologies have increased the value of biodiversity and associated traditional knowledge. To save valuable biodiversity and traditional knowledge of our country, National biodiversity board and State biodiversity board constantly involved in this approach and biodiversity law's support to conserve the living diversity.

Veerabhadraswamy al

The Banking sector influences the economic growth and development of the country both in terms of quality and quantity, there by adopting the various strategies for economic growth. Technological advancements and new initiatives of government have helped banks to provide efficient services to its customers all over the country. The study has been conducted to know the extent of problems faced by the bank customers, and their level of satisfaction towards the banking services provided by the Corporation Bank, Kodialbail Branch, Mangalore. 100 customers of the bank, who are the employees of Besant Institutions, are contacted and data was collected through questionnaire. Study revealed that 66% of respondents have faced problems in operating their bank accounts. 63% of the respondents have availed net banking facilities. Only 18% of the respondents are satisfied and 32% of respondents are neutral about the services of the bank. Some of the respondents provided valuable suggestions to improve the banking services.

Thara s shetty

The aim of the paper is to develop Indian economy growth and its impact of upcoming scenario. In the modern world education is becoming the most important resource for economic and social development of countries, improving well-being and individual development of citizens. Education in every sense is one of the fundamental factors of development. No country can achieve sustainable economic development without substantial investment in human capital. Education enriches people's understanding of themselves and world. It improves the quality of their lives and leads to broad social benefits to individuals and society. Education raises people's productivity and creativity and promotes entrepreneurship and technological advances. In addition it plays a very crucial role in securing economic and social progress and improving income distribution. Our higher education institutions serve and enrich society in many ways and their role in modern Ireland is multi-faceted

Dr gedam kamalakar

Background Worldwide, breast cancer (BC) is the most frequently discovered tumor in women. Breast self-examination (BSE) is a helpful screening method that gives women more control over their bodies by educating them about the structures of their breasts and assisting in the early detection of any developing breast abnormalities. The purpose of this research was to assess Palestinian girls' degree of BSE awareness and practice. Method A self-administered questionnaire was used to gauge participants' knowledge about BC and associated topics. Through an online survey, all girls above the age of 20 are encouraged to take part in the study. Female university students at academic levels I, II, III, and IV in Palestine were also invited to participate in the study by way of an online survey. Results The study included 467 female participants, with 69% of the individuals being single. The majority of females (68.7%) scored poorly on knowledge of BC disease (possible risk, methods of detection, methods of diagnosis, methods of treatment, signs and symptoms, information about mammography, and other knowledge questions), whereas only 31.7% scored well. Conclusion BC, which is thought to be the most common malignant development among them and the second leading cause of cancer mortality, is one of the issues that women in the West Bank face. Screening methods are crucial for the early detection of BC and for lowering disease-related morbidity and mortality. It has been advised that starting at age 20, every woman should take the BSE.

Mohamad banat

This study examines Javanese Krama's learning in improving students' ability to speak politely at MIMA 35 Nurul Ulum Ambulu. This research approach is a descriptive qualitative approach, and the type of research used is phenomenology. Data collection techniques using interviews, observation, and documentation. While the data analysis using the model of Miles, Huberman, and Johnny Saldana consists of data condensation, data presentation, and conclusion. The results of this study are 1) Planning for learning the Javanese Krama language to improve the ability of students to speak politely at MIMA 35 Nurul Ulum Ambulu, namely: the teacher prepares a Learning Implementation Plan, prepares to memorize material for the Javanese Krama language vocabulary for students. 2) Implementation of Javanese Krama language learning in improving the ability of students to speak politely at MIMA 35 Nurul Ulum Ambulu, namely: opening, core, and closing activities. Then the habit of using Javanese manners during learning hours and outside the classroom. 3) Evaluation of Javanese Krama language learning in improving the ability of students to speak politely at MIMA 35 Nurul Ulum Ambulu, namely: in the classroom using daily questions, PTS and PAS. Meanwhile, habituation outside of learning hours is by assessing students' speech and manners. 4) The implications of learning Javanese Krama in improving the ability of students to speak politely at MIMA 35 Nurul Ulum Ambulu have a positive impact on students becoming accustomed to using Javanese Krama when communicating with teachers both in attitude and speech.

Educare: journal of primary education

Dans toute société, l’homme nait, grandit et meurt. Ces étapes marquant la vie de l’être humain sont des passages obligés dans le parcours existentiel de tout être vivant. Si le premier et le deuxième éléments sont des moments de réjouissance pour les parents, les amis et la famille, le troisième par contre attriste, alite et est parfois source de discorde et de séparation des membres d’une même communauté. A la mort d’un parent, des soutiens de toutes natures viennent de toute part. Ces soutiens sont la manifestation de la solidarité au sein de nos communautés. Des chansons sont scandées avant, au cours et après l’inhumation. Comme on le constate dans plusieurs communautés linguistiques, ces chansons funéraires assument, dans la société, des fonctions diverses. Cette étude qui analyse quelques chansons aussi bien sur le plan social que linguistique, vise à montrer la valeur de la chanson et le sens qu’elle véhicule dans la communauté ajatado prenant en compte le Bénin, le Togo, le Ghana et le Nigéria sans oublier ses différentes fonctions dans la société.

Assanvo

Industrial waste is one of the most essential sources of contamination in the environment. Chromium (Cr) is a toxic heavy metal, a major contaminant in tannery wastes and its accumulation in soil and water is a major environmental concern today. In the present study, an attempt was made and investigated the status of different beneficial microbes particularly plant growth promoting rhizobacteria (PGPR) from tannery sludge samples collected from tannery effluent treatment plant at Dindugal, Tamil Nadu, India. Experiments were conducted and evaluated their chromium heavy metal tolerance abilities and plant growth promoting activities under in-vitro. Based on molecular analysis, the PGPRs were identified as Achromobacter xylosoxidans (LK391696), Azotobacter vinelandii (LK391702) and. The production of IAA was found to be high by Achromobacter xylosoxidans (46μg/ml) followed by Azospirillum lipoferum (30μg/ml). Phosphate solublization activity was also found to be positive in all these PGPR isolates. Significance of these results revealed that there is a possibility of using these potential PGPRs for bioremediation of chromium contaminated sites and also as good plant growth promoter.

Dr. saranya devi k

Plants have been used as medicine for the treatment of diseases for thousands of years. These herbal remedies, although natural, can cause some serious damaging effects on the vital organs of the body due to inadequacy in standardization and safety regulations. Mucuna pruriens Linn. belongs to the family Fabaceae and is used traditionally in various ailments. The present study reports the acute systematic toxicity and topical toxicity of methanolic extract of Mucuna pruriens (seeds) on albino mice and rabbits respectively. The test solution was injected intravenously into the tail as 1ml/20gm of the mice body weight. The observation was made immediately and after 1/2, 1, 4, 24, 48 and 72hours of drug administration. Mice showed normal activity till 72hours. The intracutaneous test is designed to evaluate local responses to the extracts of materials under test following intracutaneous injection into rabbits. The toxicological investigations of Mucuna pruriens with particular reference to intracutaneous toxicity in experimental animals displayed that it showed slight edema.

Dr. salman ahmed

Avian influenza has impacted negatively on poultry production in Nigeria. The aim of this study was to determine the status of avian influenza virus (AIV) antibodies in wild birds to provide early warning of an outbreak. One hundred and forty-six sera from five different species of wild birds were tested for antibodies to avian influenza A viruses (H5 and H9) using enzyme linked immunosorbent assay and haemagglutination inhibition (HI) tests. An overall seroprevalence of 3.4% (5/146) was recorded in the study area. Seroprevalence of 6.67% (2/30) was recorded in speckled pigeons (Columba guinea) and Village weavers (Ploceus cucullatus) respectively and 3.33% (1/30) in Cattle egrets (Bubulcus ibis). No antibodies were detected in laughing doves (Spilolepia senegalensis) and African silver bill (Euodice cantans). The serological detection of AIV subtypes H5 and H9 by HI showed the exposure of these birds to the two subtypes. The result from this study indicates evidence of the presence of H5 and H9 AI viruses in wild birds in Zaria, Kaduna State. Therefore, comprehensive surveillance of influenza A involving wild birds’ population and H5 as well as H9 subtype is recommended. This is necessary in order to know the actual status of these strains in the poultry population in Nigeria in view of their zoonotic and economic importance.

Bitrus inuwa

ABSTRACT “Numbers are the highest degree of knowledge. It is knowledge itself.”- Plato “The world is built on the power of numbers.” Pythagoras “Everything around you is numbers.” Shakuntala Devi. The date, we were born on, was not an accident. Each number in our date of birth is connected with certain energies and vibrations. Similarly, each and every letter in our name (first as well as full name) also has particular frequency, energies and vibrations. The combined and correlated energies of numbers and letters of an individual reveal about the past, present and future. The careful study of these universal divine energies can reveal, who you are, why you are here, where are you going and how will you get there. In other words what is your personality, nature, thinking, and what is your future in terms of family career relationships and finances etc. In this study, an attempt has been made to analyze -How certain patterns of name numbers and date of birth related core numbers can emerge as a directional guide for an individual to choose any specific career/profession (by studying the patterns of over 1100+ date of births and names of the Engineers cum Arbitrators).

Jyotsnaa g bansal

Over the years, pharmacy has developed from a simple floor stock system to a complex unit dose, I.V. additive, and clinical pharmacy program. This development would have never been possible without the support of the nursing, medical, and administrative staff. The support of obtained slowly by developing services that increase the pharmacist's credibility as a team member concerned with the pediatric and neonate patients. These services include a unit dose program, I.V. additive program, drug information services, and pharmacy medication program. One area in which pharmacist does not obtain a background from generalized training is the area of pediatric dosing. Pediatric pharmacists must learn in clinical practice the proper dosing of the pediatric patient and neonate patient. The dose must be checked periodically. In the premature or newborn infant, the pharmacist must consider the immature renal and hepatic function so that he/she does not overdose initially and then underdose as the infant grows and matures. Neonates are a special group of children, they are less than 30 days, and within this group preterm babies (that means less than 37 weeks). Determining the correct dose for drugs used to treat neonates is a critically vital factor. Prematurity affects kidney and liver function and the proper adjustment of drug doses is crucial [1]. The absence of drug level necessitates the adjustment of drug doses and the presence of qualified oriented dependable pharmacists. Drug doses are not numbers, or decimals used within the therapeutic range. Neonatal Intensive Care Unit (NICU) needs a system for the calculation and preparation of drugs [2].

Mediterranean journal of pharmacy and pharmaceutical sciences

Several studies demonstrate a strong correlation between talent and organizational performance. This view has led to continued improvement of methodologies, human resource scorecards, benchmarking, and engaging in best practices aimed at attracting both talent and better business management. As all these underline advancements of organizational strategic goals, it also determines the development and alignment of individual performance (Savanevičienė and Vilčiauskaitė, 2017, pg. 247). Although most of the studies involve for-profit corporations incorporating them in various industries proves to be both logical and psychologically sound. Regarding this project, the major focus is on determining talent strategies that best companies use to attract and retain people. For the project, Deloitte has been chosen as the reference organization for the strategies it uses and how its human resource management has been able to sustain attracting and retaining good talent.

Zamzam abdelazim

Anti-emetic activity Of four aromatic medicinal plants (Curcuma caesia Roxb., Piper longum Linn., Piper nigrum Linn., and Syzygiunt aromaticum (Linn.) Merr. & Perry) was studied in chicks. The ethanol extracts of these plants were administered at 150 mg/kg BW orally. All the extracts showed a significant (P < 0.05) decrease in retches induced by copper sulphate pentahydrate given orally at 50 mg /kg BW. Domperidone was given at 100 mg/kg as a reference drug.

Dr. salman ahmed

Blind Taste Test of Soft-drinks – A Comparison Study on Coke and PBrand equity is “The differential effect that brand knowledge has on consumer response to the marketing of that brand” (Keller-1993).Brand equity is the added value a product acquires as a result of past investments in the marketing activity for the brand.This marketing activity resides in the mind of customers and as a result customer shapes a perception about the brand, biggest challenge here is creating positive perceptions by ensuring that customers have right type of experiences with product so that both functional experiences as well as emotional experiences become associated with the product.Thus Brand perception is the imagewhich a brand creates in the mind of the customers due to the various associations linked with the brand. The simplest way tounderstand what brand equity is to understand the typical results of product sampling and comparison tests. One such test is blind taste test in which consumers sample a product without knowing the brand what they consume and consuming the same product knowing brand i.e., open test. When consumers report different opinions about branded and unbranded versions of identical products, it must be the case that knowledge about the brand has changed their perceptions. Thus, consumers’ perceptions of product performance are highly dependent on their impressions of the brand that goes along with it Pepsi

N ramanjaneyalu

Using off-label drugs in obstetric-gynecology patients requires caution because of the high risk of pregnancy. Although there is still debate, data profiling its use in clinical practice is lacking. This study aims to observe the use of off-label drugs in obstetrics and gynecology patients in private hospitals, especially the pill Misoprostol. This study used a descriptive observational approach to hospital medical record data. Retrieval of research data retrospectively at Bunda General Hospital (X Hospital) for July 2017 – December 2017 and Sinar Kasih Hospital (Y Hospital) for January 2018 – December 2018. The number of samples was determined using the Slovin formula, with a systematic random sampling technique at X Hospital and total sampling at Y Hospital. The samples were 220 RM at X 130 Hospital and Y 90 Hospital. The research was conducted in the period January 2019 - March 2019. The results were analyzed univariately using several related references. The results showed 26.92% of misoprostol off-label use in X Hospital and 4% in Y Hospital. The off-label drug found was Misoprostol which belongs to the category of off-label indications (Missed Abortion, Incomplete Abortion, Blighted Ovum, and Induction of labor in cases of Serotinus, KPD, and IUFD), off-label doses (50 µg, 100 µg, and 400 µg), and off-label routes of administration (sublingual and vaginal). ​

Much ilham novalisa aji wibowo

Small, medium and micro enterprises (SMMEs) represent a vital element in our economy in terms of addressing unemployment and the gross domestic product (GDP) of our country. Improving the success rate of SMMEs would save a lot of financial resources, thus understanding the financing options that complement success at different phases of the business is very important. This research sought to examine the extent to which the financing options chosen by entrepreneurs will have an impact on business success. The investigators adopted the progression of the ventures along the business life cycle stages as a benchmark for assessing success. The study focused primarily on SMMEs in the Eastern Cape Information Communication Technologies (ICT) sector. Data was obtained using an online survey which reached 50 small business owners/ business representative within the ICT sector in the Eastern Cape Province. The research study showed the role that internal financing options, such as personal savings, family, relatives and friends' financing, retained earnings, sale of existing assets and cutting down stock levels, play in the achievement of ICT SMME success. Moreover, examined external financing options such as Broad-Based Black Economic empowerment (B-BBEE) financing, bank loans, equity financing, government grants, trade credit, to SMME success. Key results revealed that the financial support of B-BBEE and personal savings have played a key role in the success of ICT SMMEs throughout the business life cycle phases. This occurs after an ICT SMME has advanced successfully over the start-up stage and aims for success in the development phase. The finding revealed that for these SMMEs to attain success at the development stage, they should finance their business investment projects utilising credit trade, bank loans, families, relatives and friends. The abovementioned financing options are only substantially linked to good advancement from the development phase onto the expansion phase. Also, suggestions have been made to the ICT SMME management to include B-BBEE finance, personal savings, bank loans, families, relatives and friends and trade credit as suitable funding choices for the ICT SMME's life cycle

Luyolo mahlangabeza

Metabolic dysfunction-associated fatty liver disease (MAFLD) and type 2 diabetes (T2D) are interconnected metabolic disorders with significant health implications. However, a comprehensive understanding of the extent of their co-occurrence in Africa is lacking. The aim of this review was to determine the prevalence of MAFLD and its association with glycemic control (HbA1c) in persons with T2D in Africa. A systematic search was conducted on PubMed, Medline, Embase, Scopus, Global Health, and Web of Science from their inception to December 6, 2023. Data on MAFLD prevalence and correlation coefficients regarding its association with glycemic control were pooled through random effect meta-analyses. Potential sources of heterogeneity were investigated using subgroup analysis and meta-regression. A total of 10 studies were included in the meta-analysis of MAFLD prevalence, while 2 were incorporated in the analysis of the association between MAFLD and glycemic control. The pooled prevalence of MAFLD in persons with T2D was 48.1% (95% CI: 36.1–60.3). The subgroup analysis revealed regional variations in MAFLD prevalence, with rates of 44.7% (95% CI: 28.7–62.0) in sub-Saharan Africa and 55.3% (95% CI: 36.2–73.0) in Northern Africa. Additionally, we observed an increasing trend in MAFLD prevalence, recording 55.1% (95% CI: 43.6–66.1) in the recent five years. There was a weak positive correlation between MAFLD and HbA1c (r = 0.33, 95% CI: 0.18–0.47). The findings of this study highlight a high prevalence of MAFLD in persons with T2D in Africa, with a suggested link between MAFLD and suboptimal glycemic control. Therefore, healthcare providers should prioritize the screening and management of MAFLD in individuals with T2D to enhance their metabolic health.

Emmanuel ekpor