Background: Effective disinfection protocols are crucial in healthcare and pharmaceutical settings to mitigate infection and cross-contamination risks, especially with a growing immunocompromised population. Disinfectant efficacy varies, and understanding microbial resistance profiles is essential. This study aimed to evaluate the differential efficacy of ethanol (ET), isopropyl alcohol (IPA), and a peracetic acid-hydrogen peroxide (PA+HP) blend against diverse microbial forms (bacterial spores, fungal spores, and vegetative yeast cells) and to analyze differences in susceptibility. Methods: The efficacy of ET, IPA, and PA+HP was evaluated against Bacillus subtilis (bacterial spores), Aspergillus niger (fungal spores), Candida albicans, and Kocuria rosea (vegetative yeast cells). Logarithmic reduction (LR) values from 10 replicates per group were analyzed using nonparametric (Friedman test with Dunn’s post-hoc) and two-way omnibus tests. Results: The Friedman test revealed significant differences across microbial groups (p < 0.0001). B. subtilis showed maximal susceptibility (LR = 6.70 ± 0.00), while A. niger exhibited minimal susceptibility (LR = 3.77 ± 0.21). ET outperformed IPA against C. albicans (LR = 5.43 vs. 4.91, p = 0.0232). The microbial group accounted for 92.36% of the variance (p < 0.0001). Conclusions: Microorganism-specific disinfection strategies were emphasized by the findings. A routine disinfectant evaluation program is crucial to mitigate microbial infection and crosscontamination risk in healthcare settings. The study highlights the importance of selecting appropriate disinfectants based on microbial resistance profiles.

Karishma

This research was carried out at SDS Harapan Jakarta. This research aims to unravel the implementation of character education’s values through thematic subject, specifically on Indonesian Language Content. This research uses qualitative descriptive approach to gather research data deeply and thoroughly regarding character education’s value. Data collection was done using interviews, observation, and documentation. Miles and Huberman method was used to analyze data collected with the process of data collection, condensation, data display, and data verification. Triangulation was used to verify the validity of the data. The result of this study revealed that 1) The implementation of character education values in the content of Indonesian Language learning in Class 3 is implemented through reading and writing activities that prioritize the five main values in education according to the Minister of Education and Culture. 2) There are still less-effective efforts to achieve learning objectives. 3) There is still a lack of learning innovations carried out to achieve learning goals. 4) No lesson plans that are not made routinely as a means of evaluating learning. 5) There is still a need for improvement in the application of character education in Indonesian content that is linked to students' real experiences, both through online and offline learning.

Educare: journal of primary education

Anemia is a common health problem among Libyan women. Age, heavy menstruation, and pregnancy are vital risk factors for this problem. In this study, we prospectively examined 60 Libyan women all of which were diagnosed with iron deficiency anemia, their hemoglobin levels were less than 10.0 g/dl. The level of hemoglobin is also analyzed for vegetarian and charcoal-eating women. We found that during pregnancy charcoal-eating women exhibit lower hemoglobin levels than non-eating women. Pregnant young women in the age of 17-27 years have the lowest hemoglobin levels than the other age groups. In addition, vegetarians, heavy coffee and tea drinking, and heavy menstruation in non-pregnant women, as well as breastfeeding, strongly lower hemoglobin levels as measured by their complete blood count.

Mediterranean journal of pharmacy and pharmaceutical sciences

A survey was conducted to screen the presences of antibiotic-resistant Salmonella from broiler chicken meat brought from local retail shops situated at Kozhinjampara, Palakkad, Kerala. Based on the morphological and biochemical characterization, a total of 15 Salmonella sp were isolated. Among 15 isolates, five (S7, S8, S10, S12, S14) isolates exhibited 100% resistance to all tested antibiotics and only one isolate S9 shows sensitivity to maximum antibiotics tested. In the study, garlic extract was tested against antibiotic-resistant isolates and it exhibited maximum inhibition against S12 isolate (30mm) and minimum inhibition against S8 isolate (22mm). The analyses of the garlic extract by GC-MS confirmed that the major components of garlic having antimicrobial activity. The result specified that garlic extract was found to be effective in controlling antibiotic resistance Salmonella species from broiler chicken meat. Therefore, incorporating garlic products in poultry feeds will help reduce antibiotic-resistant pathogenic microbes which causes drastic infections in human beings.

Dr. saranya devi k

Human being has some basic needs which include Food, Clothing & Shelter, in addition to above Healthcare, Education, Sanitation are also core part of basic necessities in modern society. In above mention basic necessities Healthcare facility was near to unavailable till independence for majority of citizens in country but this picture change dramatically with help of FDI allowed by Govt. of India. Foreign Direct Investment as a strategic element of funding is required in every develop & developing country. FDI inflows are long term in nature which causes source of non-debt finance, as well as bring modern & innovative technology in country by creating international network. In this paper, author attempted to discover how FDI is crucially impact on Indian Pharmaceutical Sectors progress by stimulating domestic investment & new employment opportunities, improving healthcare facilities to citizens in India. With the help of available relevant secondary data, a qualitative approach was followed for the study. It was found in study that the major factors responsible for attracting FDI in pharmaceutical sector are rise in outsourcing activities, demand in the generics market, demand from emerging segments, increase in domestic demand, large numbers of forthcoming patent expires. On the other hand Indian pharmaceutical industry is facing some challenges such as, low government expenditure on healthcare, poor healthcare infrastructure in rural areas, lack of proper Govt. policy to attract larger FDI in healthcare sector.

Anshuman vijay magar

ABSTRACT The 2006 International Telecommunication Union (ITU) Radio World Conference treaty concluded that all countries should migrate from analogue to digital terrestrial television by June 2015, starting with region one countries, comprising Africa, Europe, the Middle East and the Republic of Iran (Agona & Otim, 2012). The purpose of this research was to explore the technology adoption model (TAM) to address challenges associated with digital terrestrial television migration, and analyse the readiness of South Africa to migrate. A quantitative research was conducted in order to determine the relationship between dependent and independent variables. Digital television offers many benefits for broadcasters, network operators, spectrum regulators, and consumers. In most countries, the transition was slower than expected, even though most European countries managed to migrate. The digital migration is not an easy transition and analogue switch-off can also be much more difficult. Studies have shown that analogue switch off (ASO) needs to be carefully planned and well budgeted for, and it also needs a good publicity campaign which must involve all relevant stakeholders, such as broadcasters, viewers, manufacturers, network operators, manufacturers and retailers. Even though studies conducted previously identified obstacles of digital migration to include; a) lack of awareness b) lack of information, c) influence of politics and d) influence of corruption.

Luyolo mahlangabeza

Education in India is losing its relevance. This seems much more applicable to the situation in the present day of legal education. This essay aims to focus on two aspects of legal education. Whilst, on one hand, it aims to provide details of the existing legal education system on the other, it aims to drive more attention to the various improvements and developments that are needed. The essay firstly shall describe the existing legal education system. It shall analyze and assess the curricula that are available for the various undergraduate law degrees available in India. It aims to provide an understanding of the perceived distinctions between the three-year law degree and the five-year law degree. As a second aspect, the essay aims to explore options to further the quality of legal education in India by considering examples of various law schools or colleges of law across the world that have consistently proven themselves as a cut-above not legal education and research in their global scale. Also, from the learnings of the gaps in the curricula of the law degrees as discussed previously, the essay shall provide suggestions on the various plausible collaborations with foreign law schools and universities for the benefit of the Indian law schools and colleges of law. As a third and final aspect, as a measure to curb fake or bogus law schools or colleges of law within India and to enhance the employability of law graduates in India at par with those across the globe, the essay aims to provide suggestions applicable for the present-day legal education scenario.

Hari hara sudhan r

s deep learning models continue to grow in complexity, the computational and energy demands associated with their training and deployment are becomingincreasingly significant, particularly for convolutional neural networks (CNNs) deployed on CPU-bound and resource- limited devices. Fully connected (FC)layers, while vital, are energy-intensive, accounting for 85.7% of a network’s parameters but contributing only 1% of the computations. This research proposes anovel approach to optimising these layers for greater energy efficiency by integrating low-rank factorisation with differential partial differential equations (PDEs).The introduction of the LowRankDense layer, which combines low-rank matrix factorisation with a differential PDE solver, aims to reduce both the parametercount and energy consumption of FC layers. Experiments conducted on the MNIST, Fashion MNIST, and CIFAR-10 datasets demonstrate the effectiveness ofthis approach, yielding promising results in terms of reduced energy usage and maintaining comparable performance, thereby enhancing the practicality andsustainability of CNNs for widespread use in environments with limited computational resources

Jiby mariya jose

Medicinal plants are the gift of nature and play an important role as a part of our diet to maintain health. They also serve as a versatile weapon to combat several diseases. Every civilization has its own experience and knowledge of the therapeutic uses of plants. The belief and observations regarding traditionally used medicinal plants increase people's interest in using them against urolithiasis. Urolithiasis is a common problem that has been afflicted for centuries and has a high recurrence. Of the world's population, about 12% suffer from urolithiasis. All over the world, in different countries and cultures, people use plants to prevent and cure kidney stones according to their ethnopharmacological information. These formulations are very effective. That's why they have been used for hundreds of years. This review covers the eighty (80) medicinal plants of the most cited family Asteraceae against urolithiasis and their historical antiurolithiatc background shared in well-known books of Dioscorides, Pliny the Elder, Al Razi and Ibn Sina. This information was extracted to compose antiurolithiatic plants with their parts and formulations used in 21 countries such as Algeria, America, Australia, China, India, Iran, Italy, Jordan, Jordan, Kyrgyzstan, Lebanon, Libya, Mexico, Morocco, Pakistan, Palestine, Philippine, Spain, Tunisia, Turkey and Uzbekistan. Scientifically proven pharmacological activities of the same part of the plant have direct (litholytic) and direct pharmacological effects like analgesic, anti-inflammatory, antioxidant, astringent, demulcent, diuretic, litholytic, lithotriptic, antiurolithiatic, antispasmodic, ACE inhibition and Phospholipase A2 inhibition also shared as a plausible mechanism of action. The route of administration is oral in all cases. Hopefully, this book will be useful for the general public and attract the scientific world for antiurolithiatic drug discovery. This valuable ethnopharmacological information will provide opportunities for the future research and development of new natural antiurolithiatic compounds.

Dr. salman ahmed

This study investigated the effect of health education on posture practices in reducing low back pain among patients in Rivers state, Nigeria. To achieve this, pretest-posttest quasi-experimental design was employed, and the study targeted 170 patients at the University of Port Harcourt Teaching Hospital in Nigeria. Two objectives having corresponding research questions and hypotheses guided the study, while convenience and stratified sampling techniques were used to select 50 participants, comprising 35 patients from the general outpatient clinic department and 15 patients from the spine physiotherapy unit, with 20 male and 30 female participants. Data collection was done by administering a self-structured, self-administered questionnaire, titled health education effect on ergonomic practices and low back pain, which had a reliability coefficient of 0.75. Both descriptive and inferential statistics were used to answer the research questions and test the hypotheses. The research found that educating patients on various methods of preventing low back pain, including healthy weight maintenance, warm-up exercises, and proper postural habits while sitting and standing, had a noteworthy impact on reducing pain. Moreover, the study also revealed that health education programmes were successful in therapeutic posture practices and reducing low back pain in patients residing in Rivers state. Therefore, the study concluded and recommended that health education interventions for functional and therapeutic posture practices are effective strategies for reducing low back pain among patients in Rivers state, and healthcare providers should incorporate these interventions into their treatment plans for patients suffering from low back pain.

Fxintegrity publishing

The advent of the World Wide Web and the rapid adoption of social media platforms (such as Facebook and Twitter) paved the way for information dissemination that has never been witnessed in the human history before. With the current usage of social media platforms, consumers are creating and sharing more information than ever before, some of which are misleading with no relevance to reality. Automated classification of a text article as misinformation or disinformation is a challenging task. Even an expert in a particular domain has to explore multiple aspects before giving a verdict on the truthfulness of an article. In this work, we propose to use a machine learning ensemble approach for the automated classification of news articles. Our study explores different textual properties that can be used to distinguish fake contents from real. By using those properties, we train a combination of different machine learning algorithms using various ensemble methods and evaluate their performance on 4 real world datasets. Experimental evaluation confirms the superior performance of our proposed ensemble learner approach in comparison to individual learners. The advent of the World Wide Web and the rapid adoption of social media platforms (such as Facebook and Twitter) paved the way for information dissemination that has never been witnessed in human history before. Besides other use cases, news outlets benefitted from the widespread use of social media platforms by providing updated news in near real-time to its subscribers. The news media evolved from newspapers, tabloids, and magazines to a digital form such as online news platforms, blogs, social media feeds, and other digital media formats. It became easier for consumers to acquire the latest news at their fingertips. Facebook referrals account for 70% of traffic to news websites. These social media platforms in their current state are extremely powerful and useful for their ability to allow users to discuss and share ideas and debate over issues such as democracy, education, and health. However, such platforms are also used with a negative perspective by certain entities commonly for monetary gain and in other cases for creating biased opinions, manipulating mindsets, and spreading satire or absurdity. The phenomenon is commonly known as fake news.

Kamal singh

Gaucher Disease (GD) is the most common lysosomal storage disorder. The prevalence of GD is approximately 1/100,000, and type III GD accounts for 5% of cases. [1] It is an autosomal recessive disease due to a GBA gene mutation, leading to glucocerebrosidase enzyme deficiency. [1,2] Gaucher disease (GD) is categorized into three types according to clinical presentation: [3] Type I, which is non-neuronopathic and most common, particularly among Ashkenazi Jews; Type II, which is acute neuronopathic and marked by significant neurological involvement and high mortality rates; and Type III, which is subacute neuronopathic, exhibiting both systemic and neurological symptoms. In this report, we discuss a 24-year-old man from Libya diagnosed with GD type III. His diagnosis was established at the age of one due to symptoms including pallor, poor appetite, and hepatosplenomegaly. Laboratory tests indicated a hemoglobin level of 5.6 g/dL, chitotriosidase activity of 18,742 μmol/L, and an angiotensin-converting enzyme level of 251 UI/L. Genetic analysis confirmed a homozygous L444P mutation. He underwent splenectomy at the age of three, and enzyme replacement therapy (ERT) was administered intermittently with regular follow-ups until 2011. In December 2023, the patient experienced two weeks of abdominal pain, distension, and fatigue. A physical examination revealed ascites, dilated abdominal veins, and an enlarged liver and spleen.

Karishma

Formality transfer seeks to adjust text formality without altering its core meaning, which carries substantial implications across diverse domains like machine translation, dialogue systems, and social media content creation. This study provides an extensive overview of formality transfer specifically within Arabic text, an emerging domain within natural language processing. Particularly, we carried out a comprehensive review of literature on text formality transfer, focusing on studies published between July 2010 and April 2024. Our focus lies in treating formality transfer in Arabic as akin to a machine translation task, presenting synthesized insights. Despite advancements in formality transfer for English and other languages, Arabic’s distinct linguistic features present unique challenges and opportunities. Our investigation uncovers several research gaps necessitating future exploration, emphasizing persistent limitations. Moreover, we delve into text formality transfer as a promising avenue for forthcoming research initiatives in the realm of Arabic text processing.

Shadi abudalfa

The purpose of this study is to look at development trends and patterns of structural change in India's rural and labour markets. The rural labour strength have been moving from agricultural sector to non-agricultural sector for a living, after a long period of change (due to pain and growth-induced motives). Although the manufacturing sector lags, the building industry is a significant growing sector that employs rural people. Some improvements in rural areas have been made since the implementation of the MGNREGA rural employment development programme, but it has its own set of problems that experts are discussing. Furthermore, the rural labour market is plagued by high unemployment as a result of both the agricultural and non-farm sectors' failure to absorb rural employees. Nonetheless, the continuing COVID-19 epidemic has worsened its situation by causing a job-loss catastrophe. The rural labour market's future will become more unclear as a consequence of Covid pandemic-induced opposite migration of city workers to their villages, which has worsened food security and poverty issues in rural regions.

Dr. amarjeet singh

Celiac disease (CeD) is a complex disorder characterized by gastrointestinal (GI) symptoms as well as extraintestinal manifestations, sometimes difficult to diagnose. Commonly referred to as a childhood disease, adult CeD is a well-known entity that should be included in the differential diagnosis of chronic diarrhea or malabsorption syndrome. The pathogenesis involves a genetically mediated autoimmune pathway. In individuals with genetic susceptibility, the mucosa of the small intestine is damaged in response to foods containing gluten. The clinical presentation is variable and ranges from typical GI symptoms to extra-intestinal and systemic manifestations. Clinical improvement and restoration of the intestinal mucosa occur simply by eliminating gluten from the diet. We reported a case of CeD in a young man after 6 years of iron deficiency anemia (IDA), without asserting a clear etiology during this time. In our country, the search for CeD in patients with IDA is usually forgotten and we hereby put it in the spotlight.

Karishma

The present study was designed to evaluate the In vitro anti-oxidant cardio-protective activity of Hydro alcoholic bark extract of Terminalia paniculata Roxb on Isoproterenol induced Myocardial Infarction in Rat. Wistar albino rats used in this experiment were pretreated with vehicle, HAETP (200,400 and 600 mg/kg, p.o), Vit-C (20 mg/kg, p.o) for 14 days, on 14th and 15th day, Isoproterenol (85 mg/kg, s.c) was injected. After 24 h of last dose of ISO administration, ECG was recorded and serum biomarkers CK-MB, LDH, SGOT and SGPT were estimated. Further antioxidant levels were estimated from the tissue homogenates. Finally histopathological examination of heart was performed. HAETP have shown significant antioxidant activity in DPPH and reducing power methods. Moreover pretreatment with HAETP and Vit C improved ECG pattern and histopathology of heart.

Bm v swamy

The control of highly pathogenic avian influenza (HPAI) in Nigeria from inception is predicated on effective biosecurity by stamping out policy but outbreaks of the disease continued to re-occur with altered clinico-pathologic manifestations. This study undertook the qualitative assessment of the clinico- pathological features of HPAI H5N1 during the 2021/2022 outbreaks in commercial poultry and peri-domestic birds in northern Nigeria. A total of 22 commercial poultry farms with 53,932 laying chickens and 3 households with 120 backyard broiler chickens, 18 indigenous chickens, 10 peafowls and 9 geese were investigated for HPAI. The clinico-pathologic manifestations observed in commercial poultry were subtle compared to previous presentations of the disease except in the peafowls, geese, broilers and indigenous chickens. The interspecies mortality rates significantly varied from 1.6% to 19.6% for laying chickens and 33.3% to 100% for broilers, indigenous chickens, geese and peafowls. Based on the history of sudden and high mortality, clinical signs and post mortem lesions observed, three diseases; HPAI, very virulent Newcastle disease and fowl cholera were drawn out as differential diagnoses. However, a tentative diagnosis of HPAI was made and samples were sent to the National Veterinary Research Institute, Vom, Plateau State, Nigeria for confirmatory diagnosis. Results of the laboratory tests conducted on the samples using one step flu A screening and duplex real time RT-PCR and virus isolation in embryonated chicken eggs confirmed HPAI H5N1 in twenty-five farms. It is concluded that the continuous though, irregular outbreaks of HPAI and emerging clinico-pathologic manifestations are pointers to failure of control and that the disease may become endemic. It is recommended that government should review its policy on the control of HPAI to include the adoption of zoned vaccination with close monitoring.

Bitrus inuwa

Background and objectives: Heavy menstrual bleeding (HMB) is the most common clinical presentation of abnormal uterine bleeding (AUB). The objective designed for the study was to evaluate the effect of a Unani formulation in HMB (Kaṭhrat-i-Tamṭh). Methods: An open observational single arm clinical study was carried out at the Department of Ilmul Qabalat wa Amraze Niswan, National Institute of Unani Medicine, Hospital, Bengaluru. Diagnosed cases (n=30) of HMB with pelvic pathology were included in the study. Unani formulation comprises of Khurma (Phoenix dactylifera Linn), Rasaut (Berberis aristata), Talmakhana (Asteracantha longifolia Linn), Lodh pathani (SymplocosracemosaRoxb) was administered orally in powder form in a dose of 3g with 2g sugar, twice daily for seven days/cycle for three consecutive cycles.Main outcome measures were clinical response of 30-50% in menstrual blood loss (MBL) assessed with pictorial blood loss assessment chart (PBAC) and duration of bleeding (DOB). Improvement in Hb% and quality of life (QOL) assessed with menorrhagia impact questionnaire (MIQ). Data were analyzed using paired Student ‘t’ test, Results: Clinical response of 30-50% in MBL and DOB was achieved in 86.7% (p< 0.001**) and 56.7% (p< 0.001**) patients respectively and improvement in Hb% and QOL was achieved in 16.7% (p=0.228) and 100% (p< 0.001**) patients respectively. Conclusion:Unani formulation had a significant effect in controlling the bleeding by reduction in MBL and DOB with improvement in QOL

Dr ismath shameem

Background: Oral submucous fibrosis (OSF) is a persistent oral mucosal condition that carries an elevated risk of undergoing malignant transformation. Our objective was to elucidate the involvement of epithelial-tomesenchymal transition (EMT) in OSF and its progression to malignancy by studying a panel of EMT markers, thereby understanding the molecular mechanisms. Methods: An immunohistochemical analysis was done to detect the presence of E-cadherin, N-cadherin, pancytokeratin (PanCK), vimentin, α-SMA (alpha-smooth muscle actin), and CD44 in a total of 100 tissue samples. These samples comprised 40 cases of OSF, 20 cases of oral squamous cell carcinoma associated with OSF (OSFSCC), and 40 cases of oral squamous cell carcinoma (OSCC). A whole transcriptomic analysis was performed on a group of seven matched samples encompassing NOM, OSF, OSFSCC, and OSCC. Results: We observed significantly decreased expression of E-cadherin and PanCK, while N-cadherin, vimentin, α-SMA, and CD44 showed significantly higher expression in OSFSCC and OSCC as compared to OSF, both at protein and RNA levels. CD44 expression was noticeably higher in OSFSCC (p < 0.001) than in OSCC. Conclusion: Downregulation of epithelial markers with concomitant upregulation of mesenchymal and stem cell markers suggests the potential role of EMT and stemness in accelerating the pathogenesis and malignant transformation of OSF. The high levels of CD44 expression seen in OSFSCC indicate a high propensity for aggressiveness and acquisition of stem-like characteristics by the cells undergoing EMT.

Mohit sharma

High-Performance Liquid Chromatography (HPLC) is a frequently utilized analytical method that has numerous characteristics, including high selectivity, sensitivity, and a reduced time requirement. Upon using this fabulous technique, the limit of detection is reduced, and the accuracy, precision, reliability, and specificity can be expanded. This technique plays a crucial role in both qualitative and quantitative analysis throughout the various stages of drug production, from the initial discovery of the drug to its excretion from the body. The role of High-Performance Liquid Chromatography (HPLC) in pharmaceutical analysis during various stages of drug discovery, production, and clinical use, including drug pharmacokinetics, is reviewed and discussed in detail. This provides an overview of the benefits of High-Performance Liquid Chromatography from the chemical, pharmaceutical, and clinical perspectives.

Mediterranean journal of pharmacy and pharmaceutical sciences