Urolithiasis has been a common problem for centuries and has a high recurrence. This review aims to provide comprehensive information about traditionally used antiurolithiatic plants and their scientifically proven pharmacological activities like analgesic, anti-inflammatory, antioxidant, astringent, demulcent, diuretic, litholytic, lithotriptic, antiurolithiatic, antispasmodic, ACE inhibition and Phospholipase A2 inhibition as a plausible mechanism of action. A total of 503 species, 365 genera and 119 families were cited for treating kidney stones. The most cited families are Asteraceae (41), Fabaceae (34), Lamiaceae (26), Apiaceae (21), Rosaceae (19) and Poaceae (16). The most commonly used plant parts are root and rhizome (25%), mode of preparation decoction (62%), and oral administration route in all cases. This review will provide the opportunities for the future research and development of new natural antiurolithiatic compounds.

Dr. salman ahmed

Therapeutic nucleic acids demand specificity and accuracy in design as well as delivery strategies used in replacement or silencing of the target gene. Gene therapy is believed to be the therapy in which the root cause of the diseases can be treated at the molecular level. Generally gene therapy helps in the identification of the origin of the disorder instead of using drugs to diminish or control the symptoms. The application of nucleic acids to treat and control diseases is known as “gene therapy.” Gene therapy consists on the substitution or addition of a functional gene into the nucleus of a living cell, in order to treat a disease or repair a dysfunction, caused by this gene failure. This therapy is used to correct defective genes, which are responsible for genetic diseases. Thus, gene therapy can be used to prevent, treat or regulate hereditary or acquired disorders, by the production of therapeutic proteins. The gene therapy is mediated by the use of viral and non-viral vectors to transport foreign genes into somatic cells to restorative defective genes. This review focuses on viral vectors in detail.

Dr.p.v.kamala kumari

Political participation of women is essential for the functioning and vitality of any democracy. In India, despite constitutional provisions and various initiatives, women's participation in politics remains significantly lower than that of men. This study aims to delve into the factors influencing women's political participation in Indian democracy and explore avenues for their empowerment in the political sphere. Through a comprehensive analysis of existing literature, data, and case studies, this article examines socio-cultural, economic, and institutional barriers that hinder women's entry into politics. Additionally, it highlights successful initiatives and policy measures undertaken at various levels to enhance women's political participation. The study underscores the importance of addressing structural inequalities, promoting gender sensitive policies, and fostering a conducive environment for women's engagement in politics. By advocating for inclusive and equitable political representation, this research contributes to the ongoing discourse on women's empowerment and democratic governance in India.

Dr gedam kamalakar

Undergraduate students’ attitudes towards Artificial Intelligence (AI) in developing countries like Vietnam are rarely explored despite AI’s increasing presence in higher education. This study aims to investigate the attitudes of undergraduate students towards AI. A quantitative research method was used, involving a self-reported survey questionnaire. The sample consisted of 460 undergraduate students (196 males and 264 females) from five public and private universities in Ho Chi Minh City, Vietnam. Data collection took place through a cross-sectional survey in November and December 2023. The General Attitudes Towards Artificial Intelligence Scale (GAAIS), originally developed and validated in English by Schepman and Rodway (2020), was adapted to Vietnamese for this study. The scale comprised 20 items to evaluate students’ attitudes towards AI. Data analysis included descriptive statistics, Cronbach’s alpha coefficient, t-tests, and one-way Analysis of Variance (ANOVA). The results indicated a Cronbach’s Alpha value of 0.705 for the total variable, demonstrating acceptable reliability. Consequently, Vietnamese undergraduate students displayed moderately positive attitudes towards AI. The findings also revealed no significant difference in attitudes based on gender, but there was a notable variation based on the student’s year of study at university.

Le minh tien

Hemolytic uremic syndrome (HUS) is a microangiopathic thrombotic disease, which is classified into atypical, typical, and secondary types. Thrombocytopenia, acute kidney failure, and hemolysis are the main features of HUS regardless of its type. Infection with Shiga toxin-producing Escherichia coli causes typical HUS, and gene mutations trigger atypical HUS, while secondary HUS is associated with bone marrow transplantation, autoimmunity, cancer, and other diseases. New insights into the pathogenesis of HUS have emerged over the past decades, suggesting an important role of the complement system in disease pathogenesis, which has been reinforced by the efficacy of plasma exchange and monoclonal antibodies in its treatment. In this review, we performed an updated review of HUS with a focus on understanding its pathogenesis.

Karishma

The purpose of this study is to explore the impacts of foreign cartoons programs on the social behavior and attitude of Pakistani Children. It is forecasting different cartoon programs 24/7; hence, children spend most of their leisure in front of the television. All these cartoon characters affect the social life and psyche of the children and induce positive and negative mannerism in their daily lifestyles. It has found that one of the most disturbing factor is that the ferocity in children today is increasing rapidly due to following their favorite violent cartoon characters which are even different from their culture and societal norms. The issue is violence is what they see in every cartoon program in one or the other way. Their Guardians are unaware that these cartoons they let their children watch are destroying their parenting as negative forces are attacking the innocent minds of this generation. The study gives the insight of why and what is happening with non-parametric statistics studied and used for thorough analysis. The behavioral outcome of the kids like, imitating their preferred animation character, utilizing various dialects, watching the TV as opposed to deciding on outdoor games and being difficult about getting precisely the same outfits and embellishments as their adored character. This contextual analysis features the disturbing circumstance that guardians are uninformed of. There is something other than mimicking the particular character. The only traits of watching these foreign cartoon characters is that it might damage their own customs and they wildly become to believe these characters as their role models.

Zaki hasan

Aminopyrine (AM) has been used as a model substrate for investigation of drug metabolism. The major metabolic route is N-demethylation that was confirmed in liver microsomes. The aim of the present study was to identify the human cytochrome P-450 enzyme (CYP) mediating the N-demethylation of 4-di-methylaminoantipyrine (4-DMAA) to 4-methylaminoantipyrine (4-MAA). The contribution of human CYP to the metabolism of (4-DMAA) to (4-MAA) in human was investigated using virus expressed human CYP, human liver microsomes with chemical inhibition studies. The substrate of 4-dimethylaminantipyrine was employed at different concentrations (11.5, 23, 46, 115 and 230 µmol per l) with varying concentrations of selective inhibitors of CYP (CYP1A2), (CYP3A4), (CYP2C8),(CYP2A6), (CYP2D6), (CYP2C19) and (CYP1A1). 4-DMAA and 4-MAA were analysed by HPLC and enzyme kinetic parameters (Km and Vmax) were calculated from the concentration data. The transformation of 4-dimethylaminoantipyrine to 4-methyaminoantipyrine by microsomes prepared from baculovirus-expressed human CYP was pronounced with CYP2D6. The metabolism of 4-dimethylaminoantipyrine was inhibited by 60.0% and 55.17% by a concentration of 100 µmo per l of the known CYP2D6 inhibitors quinidine and moclobemide. The corresponding Ki values were 0.050 and 0.11 mM, respectively. The corresponding IC50 values were 0.06 and 0.13 mM, respectively. The enzyme CYP2D6 apparently has an important role in N-demethyl-ation of 4-dimethylaminoantipyrine.

Mediterranean journal of pharmacy and pharmaceutical sciences

Crises are unavoidable which makes response an imperative matter. Thus, the proactive style becomes an indispensable part of the readiness and preparedness in any potential crisis and can help prevent it. Besides, the reactive style is still important to deal effectively with a crisis especially regarding its recovery. Proactive and reactive styles were needed by Palestinian Presidents due to the occurrence of various crises faced by them. This study examines both proactive and reactive styles used by the Palestinian Presidents leadership during crisis. Besides, it examines how the Palestinian Presidents used these styles to deal with different crises at different times. This study used content analysis on the news stories from the New Straits Times. A total of 313 stories from1996 to 2016 pertaining to proactive and reactive styles used by Palestinian Presidents were found. The stories that included reactive style figured 67.7%, while the stories that included proactive style totaled 32.3%. For President Arafat, a total of 63% of the stories included reactive style compared to 37% of the stories that included proactive style. For President Abbas, a total of 78.4% of the stories contained reactive style compared to 21.6% that contained proactive style. Proactive style has been used only in political crises, while reactive style has been used in all crises. Providing various scenarios in dealing with crises allows other organizations and individuals to be initiative in dealing with any similar future crises. This study serves as a guideline for choosing proper prospective measures and responses to crises.

Mohammed fadel arandas

In the present study, the bacterium Achromobacter xylosoxidans was isolated from tannery effluent sludge sample in Dindugal, Tamil Nadu, India and screened for its bio-control efficacy against selected plant pathogens viz., Alternaria solani, Curvularia lunata and Fusarium oxysporum under in vitro. It was observed that maximum percent inhibition of mycelial growth of C. lunata (95%), followed by A. solani (85%) and F. oxysporum (80%). An attempt was also made for testing its plant growth promoting traits such as production of Indole acetic acid (IAA), phosphate solubilization efficacy, Hydrogen cyanide (HCN), ammonia and catalase production. Significant amount of plant growth promoting traits were noticed. Further studies on mechanism of bio-control against plant pathogens and plant growth promoting activities of Achromobacter xylosoxidans need to be conformed under in-vivo condition.

Dr. saranya devi k

Nig. J. Pure & Appl. Sci. Vol. 38 (Issue 1, 2025) e-ISSN 2756-4045 (C) 2025 Faculty of Physical Sciences and Faculty of Life Sciences, Univ. of Ilorin, Nigeria www.njpas.com.ng Corresponding Author: Okechukwu, C.O. Department of Food Science and Technology, Enugu State University of Science and Technology, Enugu, Nigeria Email: obedemeka51@gmail.com; +2347066896556 Page |5143 Evaluation of the Effects of Boiling on the Nutrient and Phytonutrient Composition of (Aduh) Aerial Yam Tubers *1 Okechukwu, C.O. 2 Odo, P.C. and 1 Igwesi, L. U. 1 Department of Food Science and Technology, Enugu State University of Science and Technology, Enugu, Nigeria 2 Department of Food Technology, Institute of Management and Technology (IMT) Enugu State, Nigeria Date Received: 13-05-2024 Date Accepted: 21-10-2024 DOI: https://doi.org/10.48198/NJPAS/24.B06 ABSTRACT This study investigates proximate, mineral and phytonutrient composition of raw and boiled yam (Aduh) flour samples. The aduh samples were divided into two equal portions. The tubers were sorted by removal of defected tubers and divided into two equal portions of one kilogram each for the pre-treatments One portion was processed raw and the second potion was subjected to boiling treatment. The proximate and mineral composition was analyzed using the method of AOAC, (2010) while the method described by Onwuka (2005) was employed in determining the phytonutrient content. The results of the proximate composition showed that the raw aduh sample had moisture content (6.37%), ash (2.33%), crude fibre (3.64%), crude protein content (9.81%), crude fat (3.86%), carbohydrate (77.21%) and energy value of 369.94%. The values of the raw sample were higher than that of the boiled sample due to the leaching away of nutrients into the boiling water. The mineral composition showed that the flours contained 205.60 – 316.31 μg/100g calcium, 139.00 – 161.00 μg/100g magnesium, 440 – 920.00 μg/100g potassium, 550.00 – 640.00 μg/100g sodium, 590.00 – 1735 μg/100g iron and 152.00 – 412.00 μg/100g zinc, respectively. The phytonutrient composition of the raw aduh flour were alkaloids (2.16%), flavonoids (1.75%), saponins (1.27%), tannin (0.21%) and phytate (1.88%) were significantly (p<0.05) reduced during boiling treatment process. Boiling treatment led to great reduction of the anti-nutritional factors. However, a slight reduction in the nutrient parameters was observed for the boiled sample but such reduction cannot be compared with the positive gains of removal of antinutrients. Thus, it is recommended that Aduh be properly cooked for at least 60 min before consumption.

Okechukwu obed chukwuemeka

Plants, the beauty of nature, have been the basis For treating human ailments. The current accepted modern medicine has gradually developed over the years and is undoubtedly the gift of God in the sense of traditional knowledge about different medicinal plants. However, what is needed are rapid screening techniques, structure base design and combinatorial chemistry for drug development under innovations, which will share the profit of products derived from indigenous plants. There is less known information about Ficus exasperata Vahl., and Cleome ciliata Schmach and Thonn. However, the author of this book presents comprehensive information about traditional uses and the biological and phytochemical investigation of Ficus exasperata Vahl. and Cleome ciliata Schmach and Thonn.

Dr. salman ahmed

Pneumocephalus is a rare condition characterized by the presence of intracranial air, most commonly seen after head trauma or surgery. Although it is often asymptomatic, it can lead to serious complications such as tension pneumocephalus and seizures. This study presents a case of iatrogenic pneumocephalus and seizures that developed after a flap rotation operation in a patient with a history of craniotomy. An 82-year-old male patient presented to the emergency department shortly after flap rotation surgery with loss of consciousness and generalized tonicclonic seizures. Brain computed tomography revealed a left temporal bone defect and epidural air collection. Diffusion magnetic resonance imaging showed no acute ischemic lesion. The patient was initially started on levetiracetam, but due to side effects, he was switched to a combination of valproate and lamotrigine. The patient developed pneumonia during follow-up and was treated in the intensive care unit and discharged in stable condition. In patients who have previously undergone craniotomy, the risk of pneumocephalus should be considered even in minor surgical procedures, and early imaging should be performed when new neurological symptoms develop.

Karishma

Plants a wealth of secondary metabolites have been used for thousands of years to treat different ailments. A number of these natural products have shown biological and pharmacological activities and serve as the starting point in the development of modern medicines. Screening of crude plant extracts open the door for the way for discovery of novel bioactive compounds and elucidation of their structures leads towards new synthetic preparations, which can be administered in reproducible, accurate doses for particular therapeutic purposes. There is less known information about Samanea saman Merr., and Prosopis cineraria Druce. However, authors in this book present comprehensive information about traditional uses, biological and phytochemical investigation of Samanea saman Merr., and Prosopis cineraria Druce.

Dr. salman ahmed

This work was focused on identification and evaluation of process parameters of modified nanoprecipitation method, for fabrication of lomustine nanoparticles, with the aim of reducing cancer cell viability at low concentration of lomustine. The parameters controlling particle size, mostly in nanosize, were solvent/nonsolvent composition and emulsification speed of homogenizer along with aqueous phase volume. This controlled particle size is below 250 nm. The stabilizer concentration controlled particle size is within 68 nm ± 0.89 to 137 ± 0.94 nm with PDI 0.06 ± 0.008 to 0.25 ± 0.001. But, the stabilizer addition mode showed more uniform size distribution with PDI 0.085 ± 0.004. Entrapment efficiency was maintained well above 47 ± 0.23%. The drug release pattern was monophasic with controlled release over 24 hrs. In the method used, drug content was affected by ratio of polymer to drug to organic solvent, as well as homogenization speed and time. Percentage viable cells of L132 human lung cancer cell line remained, were only 5% at 100 μg/ml lomustine equivalent PLA nanoparticles.

Archana mehrotra

In this report, Abacus Ltd employee will offer his client guidelines, another organisation trying to comprehend risk management. Abacus gives a scope of business consultancy administrations to their clients which assist them with developing their business. Abacus's new client wants all individuals from the senior group to comprehend risk management in business and the various kinds of danger (Aven and Renn, 2010).

Zamzam abdelazim

Improving the agricultural productivity is an imminent need to meet the food requirement of constantly growing population rate. It can be gracefully satisfied if the farming process is integrated through technologies such as big data and IoT. The integration of agricultural processes with modern technologies has emerged as the smart agriculture technology. This research work is focused on proving the suitability of the big data analytics for smart agricultural processes in terms of increasing production and quality of yields with less resources and overhead. This research paper expounds the extensive review carried out on the related works in smart agricultural farming, challenges in implementing the smart farming technologies at large scale, followed by the conceptual framework model for the effective implementation of big data together with IoT devices in smart farming.

Dr h shaheen

Brilliant Grid is intended to incorporate progressed correspondence/organizing innovations into electrical power frameworks to make them ''more intelligent''. The current circumstance is that a large portion of the power outages and voltage lists could be forestalled in the event that we have better and quicker specialized gadgets and advancements for the electrical matrix. To make the flow electrical force lattice a Smart Grid, the plan and execution of another correspondence framework for the lattice are two significant fields of examination. Be that as it may, Brilliant Grid projects have just been proposed as of late and a couple of recommendations for forward-looking necessities and starting exploration work have been offered in this field. No efficient audits of correspondence/organizing in Smart Grids have been led at this point. In this manner, we direct an orderly survey of correspondence/organizing innovations in Smart Grid in this paper, including correspondence/organizing engineering, distinctive correspondence innovations that would be utilized into this design, nature of administration (QoS), upgrading the use of resources, control and the board, and so forth.

Dr.a.shaji george

Purpose Noise pollution is a common health hazard worldwide which is emitted along with chemical air pollutants, simultaneously from many sources. Some studies have been conducted to control these pollutants, simultaneously with promising results being achieved. Dielectric beads have been used in air pollution control technologies, successfully and probable effectiveness of them in noise reduction can be promising in dual use of them in the exhausts emitting noise and air pollution, simultaneously. Methods In order to investigate the effectiveness of dielectric beads in noise reduction, two types of them; namely glass and ceramic beads, were placed separately inside the connecting tube of a double-expansion chamber muffler. Then the transmission loss (TL) of muffler was examined using impedance tube. A factorial design was used to evaluate and optimize the effect of noise related parameters on TL of such a system. Results Results show that the presence of dielectric beads has significant effect on TL of muffler. The maximum TL was obtained as 74.76 dB for muffler with ceramic beads, under the optimal condition of 5250 Hz and 120 dB. Measurement of TL and sound absorption coefficient (SAC) of glass and ceramic beads showed that the noise reduction in muffler with ceramic and glass beads is probably due to SAC in ceramic beads and noise reflections in glass beads, respectively. Conclusion These results promise the dual use of dielectric beads in the exhausts emitting noise and air pollution simultaneously.

Niloofar

Artificial Intelligence (AI) is redefining the future of business by transforming traditional processes, driving innovation, and fostering sustainable growth. This research paper explores the strategic integration of AI in Indian business ecosystems, aiming to identify its role in achieving the vision of Viksit Bharat@2047. The study emphasizes how AI can accelerate economic growth, enhance productivity, and address pressing challenges across sectors such as manufacturing, services, startups, and agri-business management. Using a mixed-methods approach, the research combines qualitative insights from industry experts and quantitative data analysis to assess the readiness and impact of AI adoption in businesses. Key findings indicate that while AI technologies have immense potential to streamline operations, optimize supply chains, and drive decision-making, several challenges persist, including skill gaps, ethical concerns, and infrastructural limitations. The study underscores the importance of leveraging AI for sustainable development, employment generation, and global competitiveness. Policy recommendations focus on fostering an innovation ecosystem, strengthening governance, and investing in upskilling initiatives to ensure inclusive growth. By aligning AI strategies with Indian Knowledge Systems, this research provides actionable insights for businesses, policymakers, and stakeholders committed to shaping a technologically empowered India by 2047.

Dr tatayya bommali

Environmental factors are known to influence carcinogenesis. Pollutants, such as heterocyclic amines (HAs) and polycyclic aromatic hydrocarbons (PAHs) are examples of environmental borne procarcinogens. Procarcinogens are not active carcinogens although, they require bio-activation, via enzymes such as cytochrome P450 (CYP) to transform to active product. CYP1A1 isoform, regulated by aryl hydrocarbon receptor (AhR) plays a significant role in the bio-activation of PAHs and HAs. AhR has multiple co-activators and co-repressors for AhR that have been identified S remarkably. Silencing mediator for retinoid and thyroid hormone receptors (SMRT) was designated as a major co-repressor for AhR. In the present study, it is examined the effect of SMRT over expression on the cyp1a1 mRNA levels in murine hepatoma Hepa 1c1c7 cell line. Hepa 1c1c7 cells were maintained in Dulbecco’s Modified Eagle Medium (DMEM) and competent cells have successfully been produced using calcium chloride method. Cells were transformed using plasmid DNA and Lipofectamine. TCDD (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin) was employed as an inducing agent for CYP1A1. The total cellular RNA was isolated and real-time PCR of Cyp1a1 was conducted. A statistical analysis was conducted by using one-way analysis of variance followed by Student-Newman-Keuls test. The results showed that cells transfected with the co-repressor SMRT has lower TCDD-mediated induction of cyp1a1 mRNA without affecting constitutive Cyp1a1 mRNA levels, i.e., SMRT was able to significantly decrease inducible Cyp1a1 mRNA levels in Hepa 1c1c7 cells. The present findings also demonstrated that calcium chloride is a convenient method for routine transformation. Thus, this study opens a new avenue for the management of carcinogenesis involving CYP1A1 inducing carcinogens.

Mediterranean journal of pharmacy and pharmaceutical sciences