Role of demodex infestation in blepharitis and coconut oil as a treatment option

Purpose: To assess incidence of demodex species, correlate ocular symptomatology, evaluate efficacy of coconut oil as treatment method in all types of blepharitis. Materials and Methods: 30 patients with anterior & mixed blepharitis, meibomian gland dysfunction & non-specific irritation were enrolled for study. History taken & examined clinically. 2 lashes/lid were sampled & mounted on slides with normal saline & observed under light microscope. Number of mites counted. Patients positive for demodex were treated with coconut oil application over lid margins & reviewed after 3 weeks. Results: Incidence of demodex was 40% & it increased with age. Demodex was commonly associated with meibomian gland dysfunction, non-specific irritation, madarosis, cloudy & toothpaste like meibum quality. Burning sensation and itching were common complaints. At 3rd week, all patients were symptom-free. Mite count dropped by 52.8% but were not eliminated. Conclusion: Demodex infestation is often overlooked but it is associated with about half of blepharitis cases. Hence further evaluation should be considered. Coconut oil is an easily available mode of treatment & helps reduce symptoms and mite counts.

Kamal Singh Kamal singh

Obsessive compulsive disorder symptom exacerbation during covid-19 related lockdown managed with homoeopathy: a case report

Background: Obsessive compulsive disorder (OCD) is one of the most personally distressing, and disabling psychiatric condition. COVID 19 pandemic and country wide lockdown are likely to exacerbate the symptoms in diagnosed cases of OCD. Homoeopathy, an established system of medicine with potential relevance to mental health issues has a sparse literature in management of OCD. Objectives: The primary purpose of this case report is to point out the usefulness of Individualized homoeopathic medicine in treatment of OCD. The secondary purpose is to highlight the utility of similimum in the management of exacerbation of psychiatric conditions due to stressful life situations. Methods: A case of OCD reported in Psychiatry out Patient Unit treated by Classical Homoeopathy is presented in this case report. The case was assessed at baseline and follow up visits with Yale Brown Obsessive Compulsive Scale (Y-BOCS). Results: Baseline Y-BOCS score of 24 (Severe OCD) turned gradually to subclinical range of seven within 6 months. Patient had excellent relief for next six months and was functionally well. A comparatively milder exacerbation of symptoms (Y-BOCS-17) during lockdown could be managed effectively with the repetition of similimum resulting in subclinical score of five quickly within a month. Conclusion: Homoeopathic medicine is useful in the management of OCD and also symptom exacerbation due to stressful life events like lockdown.

Dr deepthi gilla

Application of hofstede’s model to study the role of indian culture for sustenance during covid-19”

The COVID-19 crisis has impacted all dimensions of our lives say it as the public health, the labour system, the social interaction, the political debate, the use of public spaces, the economy, the environment, and last but not the least it has proved to be a major contributor to the cultural value system of the individual living in society. This research paper is to analyse and understand the changes enforced by this pandemic on Indian culture and individual of the society. It also analyses the context of COVID-19 scenario with special reference to Indian culture and Hofstede’s theory of cultural dimension. This research paper is an attempt to emphasize the changes in culture and value system during the COVID-19 pandemic faced by India. India is enriched enough in cultural dimensions to combat COVID-19. The Hofstede’s model analysed in depth also leads to this finding that it also fits well in the present context. Thus, it is hereby summed up that as India is enriched in its cultural values it has posed itself as a fighter for this pandemic

mamta gaur Mamta gaur

Study on compensation, organizational commitment, and work motivation for employee retention at a local hospital

Human resource management is critical for hospitals but is frequently disturbed by employee retention issues. This research aims to determine the influence of compensation, organizational commitment, and work motivation on employee retention at Malahayati Medan. The research method applied is quantitative research by collecting data through questionnaires distributed from July to October 2022. The sampling method used is purposive sampling, with 78 employees as the sample. The data analysis method used is descriptive statistics, coefficient determination, multiple linear regression analysis, and hypothesis testing with t-test and F-test. The results of the t-test are compensation, organizational commitment, and work motivation partially influence employee retention. The results of the F test showed that all independent variables simultaneously influence employee retention and 61.1% of employee retention is influenced by compensation, organizational commitment, and work motivation. It is recommended for companies in similar industries pay attention to the results of this research.

L L

Social factors influencing mental health: insights, preventive strategies, and policy recommendations

Introduction: Mental health disparities are deeply entrenched within the fabric of societal inequalities, shaped by structural factors that perpetuate intergenerational cycles of disadvantage. Addressing these disparities is crucial for promoting social justice and improving public health outcomes. Aim: This paper aims to synthesize high-quality evidence to elucidate the causal relationships between social determinants and mental health outcomes. It prioritizes pervasive social determinants that influence major mental disorders across the life course and outlines preventive strategies to mitigate these effects. Methodology: A comprehensive literature review was conducted, focusing on publications from the Global North from 2014 to 2024, to explore the influence of social determinants on mental health. Keywords such as "social determinants," "mental health outcomes," "preventive strategies," and "vulnerable populations" guided the search across databases like PubMed and Google Scholar. Results: The review highlights significant associations between mental health and social determinants such as socioeconomic status, racial and ethnic marginalization, and exposure to adverse environments. It underscores the heightened vulnerability of marginalized groups, including refugees, LGBTQ+ individuals, and those living in poverty. The paper introduces a preventive framework to guide primary prevention efforts and reviews both primary and secondary strategies to improve mental health equity. Conclusion: Strategic interventions aimed at the root social causes of mental health disparities can substantially enhance public mental health. This paper provides seven strategic recommendations focused on social justice, offering a roadmap for researchers, policymakers, and public health professionals to address these pressing issues.

Prof.K.C Yadav Prof.k.c yadav

Management of solid healthcare wastes in some government healthcare facilities in enugu state, southeast nigeria: a cross-sectional study

Background: The significance of healthcare wastes (HCWs) consists in their hazardous component, which constitutes real danger to public health. In Nigeria, healthcare waste management (HCWM) has remained a problem yet to be properly recognized and so addressed. The study aimed to sensitise health workers and the public on the need for proper management of HCWs, considering the public health implications of not doing so. Methods: The waste management systems of ten healthcare facilities (HCFs) were assessed, using a modification of the WHO rapid assessment tool. In each HCF, segregated wastes were collected daily for ten days and quantified by weighing, using a spring balance. Results: Administratively, the HCWM system was poor in the ten HCFs (40.6%). 70% of them had satisfactory waste segregation, 81%, good waste treatment, and 26.7% adequate transportation methods for waste. None of the HCFs had budget allocation for HCWM, and 90% had inadequate storage facilities. Mean waste generation was 1.81 kg/day, 0.23 kg/patient/day, 0.16 kg/bed/day, and proportion of infectious wastes 16.8%. Correlation between the number of patients and proportion of infectious waste, was positive, strong and significant (r=0.80, p=0.01), and between bed occupancy rate and proportion of infectious waste, was positive too, but weak, and insignificant (r=0.34, p=0.34). Conclusions: In view of the identified weaknesses of the ten HCFs in HCWM, budget allocations for HCWM, improving waste storage facilities and transportation, with strengthening of waste segregation, collection, and treatment, would help to ensure adequate HCWM in the HCFs.

Emmanuel umegbolu

Prevalence of tuberculosis in hadramout al-sahel, yemen: a 1-year cross-sectional study

Background: There is a lack of adequate data about the prevalence and types of tuberculosis (TB) disease in Hadramout Al-Sahel, Yemen. Hence, this study aimed to investigate the prevalence, types, and outcomes of TB disease in Hadramout Al-Sahel, Yemen. Materials and Methods: This cross-sectional study was conducted at the National TB Program (NTP) center in the city of Al Mukalla, Hadramout, Yemen. The study enrolled TB patients from different districts of Hadramout Al-Sahel who had registered at the NTP center between January 1 and December 31, 2021. Results: A total of 127 new active TB cases were recruited, including 102 (80.3%) with pulmonary TB (PTB) and 25 (19.7%) with extra PTB (EPTB). The overall prevalence of TB disease in 2021 was 12.7 new TB cases per 100,000 population, while the median age of the study population was 38 years. The majority of cases (23.6%) belonged to the age group of 35–44 years. There were 85 (66.9%) males, and most patients (74; 58.3%) were identified in Al Mukalla City. EPTB was detected in 25 (19.7%) patients, with pleural effusion being the most frequent manifestation, found in 12 (48.0%) patients. All patients received 4-agent anti-TB therapies; 99 (77.9%) patients received anti-TB therapy for 6 months; 9 (7.1%) patients received anti-TB therapy for 9–12 months; 8 (6.3%) patients died during treatment; and 11 (8.7%) patients were lost during follow-up. The majority of patients (108; 85%) were cured on completion of treatment. Conclusion: The prevalence of TB in Hadramout Al -Sahel was 12.7 cases per 100,000 population. Males were affected more than females; the pleura was the most commonly affected extrapulmonary site; and 85% of cases were cured. The results indicated the need to support the Al Mukalla NTP center, by providing more resources for improved TB reporting and for conduct of surveillance to detect new TB cases among high risk groups. Health authorities are also urged to provide state hospitals with the equipment needed for TB diagnosis.

Karishma Karishma

Mokhtar r. haman: a dedication to his memory

It is with more sorrow and tremendous sadness we remember the death of our colleague the Libyan pharmacist, professor Mokhtar Ramadan Haman, at his home in Tripoli, Libya after long-suffering from brain cancer. He died on 02, February 2017 and his immaculate corpse was buried on the following day at the Souk-Al-Ahad cemetery, Bin Ghashir Palace. Professor Haman, was born in Tripoli, Libya, on January 1, 1957. He obtained his Bachelor of Pharmaceutical Sciences in 1981 at the University of Tripoli and his Ph.D. in Pharmacognosy in 1989 at Cardiff University, UK.

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences Mediterranean journal of pharmacy and pharmaceutical sciences

Liposomes for drug delivery - liposomes

Liposomes are a novel drug delivery system (NDDS), they are vesicular structures consisting of bilalyers which form spontaneously when phospholipids are dispersed in water. They are microscopic vesicles in which an aqueous volume is entirely enclosed by a membrane composed of lipid bilayers. NDDS aims to deliver the drug at a rate directed by the needs of the body during the period of treatment and direct the place of action. Liposomes are colloidal spheres of cholesterol non-toxic surfactants, sphingolipids, glycolipids, long chain fatty acids and even membrane proteins and drug molecules or it is also called vesicular system. It differs in size, composition and charge and drug carrier loaded with variety of molecules such as small drug molecules, proteins, nucleotides or plasmids etc. Few drugs are formulated as liposomes to improve their therapeutic index. Hence a number of vesicular drug delivery systems such as liposomes, niosomes, transfersomes and pharmacosomes are developed. The focus of this chapter is to the various method of preparation, characterization of liposomes, advantages and applications, etc. Liposomes for Drug Delivery - liposomes

Kamal Singh Kamal singh

Surah mulk

In the name of Allah, Most Gracious, Most Merciful. Blessed be He in Whose hands is Dominion; and He over all things hath Power;- He Who created Death and Life, that He may try which of you is best in deed: and He is the Exalted in Might, Oft-Forgiving;- He Who created the seven heavens one above another: No want of proportion wilt thou see in the Creation of (Allah) Most Gracious. So turn thy vision again: seest thou any flaw? Again turn thy vision a second time: (thy) vision will come back to thee dull and discomfited, in a state worn out. And we have, (from of old), adorned the lowest heaven with Lamps, and We have made such (Lamps) (as) missiles to drive away the Evil Ones, and have prepared for them the Penalty of the Blazing Fire. For those who reject their Lord (and Cherisher) is the Penalty of Hell: and evil is (such), Destination. When they are cast therein, they will hear the (terrible) drawing in of its breath even as it blazes forth, Almost bursting with fury: Every time a Group is cast therein, its Keepers will ask, “Did no Warner come to you?” They will say: “Yes indeed; a Warner did come to us, but we rejected him and said, ´Allah never sent down any (Message): ye are nothing but an egregious delusion!´” They will further say: “Had we but listened or used our intelligence, we should not (now) be among the Companions of the Blazing Fire!” They will then confess their sins: but far will be (Forgiveness) from the Companions of the Blazing Fire! As for those who fear their Lord unseen, for them is Forgiveness and a great Reward. And whether ye hide your word or publish it, He certainly has (full) knowledge, of the secrets of (all) hearts. Should He not know,- He that created? and He is the One that understands the finest mysteries (and) is well-acquainted (with them). It is He Who has made the earth manageable for you, so traverse ye through its tracts and enjoy of the Sustenance which He furnishes: but unto Him is the Resurrection. Do ye feel secure that He Who is in heaven will not cause you to be swallowed up by the earth when it shakes (as in an earthquake)? Or do ye feel secure that He Who is in Heaven will not send against you a violent tornado (with showers of stones), so that ye shall know how (terrible) was My warning? But indeed men before them rejected (My warning): then how (terrible) was My rejection (of them)? Do they not observe the birds above them, spreading their wings and folding them in? None can uphold them except (Allah) Most Gracious: Truly (Allah) Most Gracious: Truly it is He that watches over all things. Nay, who is there that can help you, (even as) an army, besides (Allah) Most Merciful? In nothing but delusion are the Unbelievers. Or who is there that can provide you with Sustenance if He were to withhold His provision? Nay, they obstinately persist in insolent impiety and flight (from the Truth). Is then one who walks headlong, with his face grovelling, better guided,- or one who walks evenly on a Straight Way? Say: “It is He Who has created you (and made you grow), and made for you the faculties of hearing, seeing, feeling and understanding: little thanks it is ye give. Say: “It is He Who has multiplied you through the earth, and to Him shall ye be gathered together.” They ask: When will this promise be (fulfilled)? – If ye are telling the truth. Say: “As to the knowledge of the time, it is with Allah alone: I am (sent) only to warn plainly in public.” At length, when they see it close at hand, grieved will be the faces of the Unbelievers, and it will be said (to them): “This is (the promise fulfilled), which ye were calling for!” Say: “See ye?- If Allah were to destroy me, and those with me, or if He bestows His Mercy on us,- yet who can deliver the Unbelievers from a grievous Penalty?” Say: “He is (Allah) Most Gracious: We have believed in Him, and on Him have we put our trust: So, soon will ye know which (of us) it is that is in manifest error.” Say: See ye?- If your stream be some morning lost (in the underground earth), who then can supply you with clear-flowing water?

Kamal Singh Kamal singh

Role of technology in shaping the higher education in future

In recent years, the educational landscape has changed drastically with increased connectivity and technology that promotes outside-the-box thinking and innovation. Classrooms at all levels are evolving to meet this "new normal" through virtual lessons, smart technology in schools and online access for students and parents an individual possession of knowledge, skills and experience through education certainly transforms the nature’s endowed resources as marketable products/services with ‘economic value’ is termed as human capital and knowledge economy. Enhance and enrich of human capital fillips nation’s sound and health economy is the rationale of education. Education thrives to (a) educate, enlighten and encourage teaching, (b) input of understanding and (c) spirit and urge true facts. Education policy needs a clear-cut and transparency to lead in commercialisation and determination of values and proactive to the market logic. The great challenges accompany have been thoroughly exposed in recent periods through Covid-19 crisis. Interaction and integration with the economy of the rest of Worlds Counties, has now become a new emerging facet to bring out a unifying roof of the whole-teaching contents and methodology to attain the socio-economic development. To become a world-class academic institute heavily depends upon the committed faculty, quality infrastructures, supportive administration, and learning environment. Last but not least is the hardworking and brilliance or vividness is the foremost factor of promising among the young students. The corporate philanthropy to higher education is the call of the day to ensure trueness of education system for urging the prime goal of socio-economic development. This study focuses on the emerging trends in Indian higher education.

Dr Gedam Kamalakar Dr gedam kamalakar

[pdf] from imist.ma modeling of some cyclic peroxy ketals for their antimalarial activities

In this work a set of some cyclic peroxy ketals were tested for their antimalarial activities. Quantitative structure activity relationship (QSAR) analysis was applied to 20 organic compounds of the above mentioned derivatives using Physicochemical, informational and 2D-autocorelation parameters and modeled their antimalarial activity (logIC 50) values. The multiple regression analysis clearly indicates that 5 BIC, 1 IC, MATS4v and ST parameters yielded the best model having R 2 value of 0.9515. The predictive powers of the models were explained using LOO (Leave-One-Out) Cross validation procedure. The results are also discussed on the basis of ridge regression.

Dr. Shweta Sharma Dr. shweta sharma

In covid-19 pandemic; social support requirements and midwifery approaches to women during pregnancy, childbirth and the postpartum period

The novel coronavirus pandemic is affecting the whole world and it is predicted that the process will continue for a long time. The health, economic and social problems caused by this process have greatly affected women as well. In addition to the problems endured by the general population, women are facing additional challenges involving their reproductive health, pregnancy, childbirth and postpartum period. Women are trying to deal with a range of concerns, from difficulties in accessing family planning services to being unable to meet their own basic reproductive health needs. Under the pandemic conditions, it has become increasingly difficult for social services to respond sensitively to women's particular needs. The needs of coronavirus patients take precedence, and the women’s needs remain in the background. Women are facing stress, anxiety, fear, as well as disease. So, midwifery practices need to be revised to adapt to the pandemic conditions. This revision must involve not only technical issues but also psychosocial adjustments. Women have been demanding home births on social media, and this is a subject that require some legal regulations. Respect for women's birth is one of their most fundamental rights. National criteria should be developed to accommodate the support structures needed for a home birth. The social support that midwives offer women during pregnancy, childbirth and the postpartum period, play a key role. Since it is important to increase the awareness of midwives in this regard, this article deals with women's needs for social support and possible midwifery approaches for supporting women through their pregnancy, childbirth, and the postpartum period.

Reyhan Aydin Doğan Reyhan aydin doğan

Fake news detection using machine learning ensemble methods

The advent of the World Wide Web and the rapid adoption of social media platforms (such as Facebook and Twitter) paved the way for information dissemination that has never been witnessed in the human history before. With the current usage of social media platforms, consumers are creating and sharing more information than ever before, some of which are misleading with no relevance to reality. Automated classification of a text article as misinformation or disinformation is a challenging task. Even an expert in a particular domain has to explore multiple aspects before giving a verdict on the truthfulness of an article. In this work, we propose to use a machine learning ensemble approach for the automated classification of news articles. Our study explores different textual properties that can be used to distinguish fake contents from real. By using those properties, we train a combination of different machine learning algorithms using various ensemble methods and evaluate their performance on 4 real world datasets. Experimental evaluation confirms the superior performance of our proposed ensemble learner approach in comparison to individual learners. The advent of the World Wide Web and the rapid adoption of social media platforms (such as Facebook and Twitter) paved the way for information dissemination that has never been witnessed in human history before. Besides other use cases, news outlets benefitted from the widespread use of social media platforms by providing updated news in near real-time to its subscribers. The news media evolved from newspapers, tabloids, and magazines to a digital form such as online news platforms, blogs, social media feeds, and other digital media formats. It became easier for consumers to acquire the latest news at their fingertips. Facebook referrals account for 70% of traffic to news websites. These social media platforms in their current state are extremely powerful and useful for their ability to allow users to discuss and share ideas and debate over issues such as democracy, education, and health. However, such platforms are also used with a negative perspective by certain entities commonly for monetary gain and in other cases for creating biased opinions, manipulating mindsets, and spreading satire or absurdity. The phenomenon is commonly known as fake news.

Kamal Singh Kamal singh

What really matters: experiences of emergency remote teaching in university teaching and learning during the covid-19 pandemic

The COVID-19 pandemic and related lock downs have accelerated the need for online and remote teaching within university settings. However, due to the abrupt nature of the pandemic, many academic staff were not prepared for this forced transition. This study aimed to understand how the pandemic affected academics at a New Zealand university, with regards to their transition to emergency remote teaching. Specifically, it explores the challenges as well as benefits academics experienced during this transition. Recommendations for future online learning are also made. Academic staff (N 67) at a New Zealand University completed an anonymous online survey. Quantitative data were analyzed statistically using descriptive and inferential statistics, while qualitative data were analyzed thematically. Major challenges experienced included miscommunication from the university, concerns about student access to technology, finding a quiet space to work, lack of digital competence skills, too much screen-time, managing work hours, and work/ life balance. Benefits included enhanced flexibility, enhanced teacher creativity, increasing autonomy of learners, and reduced commute time. Looking forward, academic staff desired future teaching to include blended learning and virtual immersion. New strategies of working remotely are being explored to facilitate teaching and learning while catering to the preferences and skills of both educators and students. Our findings honor the considerable agility of academic staff who sought to sustain and enhance excellence in remote education. At an institutional level our findings point to the need for staff to be supported by their institutions as they further refine their work within new-found spaces

Gwen Erlam Gwen erlam

Multidisciplinary residential treatment of type 1 diabetes mellitus and co-occurring eating disorders

Research on treatment for diabetes and co-occurring eating disorders is sparse. We examined outcomes from multidisciplinary residential treatment for women with type 1 diabetes and eating disorders and the impact of treatment duration on outcomes. Participants were 29 women with type 1 diabetes and eating disorders receiving residential treatment. Repeated measures analyses of variance examined changes in blood glucose and psychological symptoms over treatment. Analyses were repeated to include treatment by duration interactions. Treatment produced significant reductions in blood glucose, eating disorder symptoms, and psychological concerns. Longer treatment duration was associated with greater improvements in psychological symptoms. Disordered eating is alarmingly common among individuals with type 1 diabetes mellitus, with rates of co-occurring diabetes and eating disorders estimated as high as 40% (Young etal., 2012; Young-Hyman & Davis, 2012). The most commonly noted link between type 1 diabetes and eating disorders is in the form of purging through insulin omission for weight loss purposes (Darbar & Mokha, 2008), which has been noted for individuals with diabetes co- occurring with anorexia nervosa (AN), bulimia nervosa (BN), and eating disorder not otherwise specified (EDNOS; Nielsen, 2002; Peveler & Fairburn, 1989). However, even among individuals with diabetes who do not omit insulin, eating disorder symptoms are elevated (Jones, Lawson, Daneman, Olmsted, & Rodin, 2000).

John Dolores John dolores

Dr.ismath shameem

Background: Unexplained infertility is a frustrating diagnosis both for the patient and the clinician, with a prevalence of 16%-37%. It commonly refers to a ‘diagnosis’ made when tubal, ovulatory and husband factors are ruled out. A couple is usually referred for evaluation after 1 year of unsuccessful trials of conception with unprotected intercourse in the fertile phase of the menstrual cycle. Unani formulation comprises of baikh asgand (Withania somnifera Dunal), baikh piyabansa (Barleria prionitis Linn), gule dhawa (Anogeissus latifolia) and gule nilofar (Nymphaea alba Linn) were used for the treatment of uqr, possessing the properties of muqawwi rahim, moaene hamal, moallide mani, etc. Case presentation: A married couple (22 years female partner & 26 years male partner) presented to NIUM Hospital OPD, with chief complaint of failure to conceive since 5 years. The couple report a high degree of stress related to their lack of success. Investigations were carried to check for tubal patency, ovulatory function and semen analysis. Diagnosis of unexplained infertility was made after thorough evaluation of the case. The powder of above mentioned formulation was given 6g twice a day orally with milk from 5th day of cycle for 5 days. Patient got conceived after taking treatment for two consecutive cycles. Discussion: Here we report evidence based management with Unani medicine to help combat the significant physical, psychosocial and economic toll on couples. Keywords: Unexplained infertility; Primary infertility; Uqr; Muqawwi rahim; Moaene hamal; Moallide mani; Unani medicin

Dr ismath shameem

Quality evaluation of functional bread produced from blends of wheat and soy-okara flour

This present study evaluated the quality attributes of functional bread developed from the blends of wheat and soy-okara (SOF) flour. A completely randomized design which generated six (6) experimental runs based on different combinations of wheat (60–90%) and soy-okara (10–40%) flours was adopted for the production of functional bread. The flour blends were processed into bread and analyzed for sensory properties. The optimum flour combination in obtaining higher sensory acceptability was 85.34% WHF and 14.66% SOF with desirability function of 85% using numerical optimization techniques. The control (100% whole-wheat bread) and optimized bread produced were assessed for physicochemical, antioxidant properties and sensory qualities. The carbohydrate, calcium, phosphorus, and sodium of the optimized bread were significantly higher (p<0.05) than in the control sample having 58.14 and 75.14%, 128.80, and 75.60 mg/100 g, 68.18 and 63.77 and 13.83 ppm and 12.62 ppm respectively. The total flavonoid and phenolic contents of the control and optimized bread were significantly (p<0.05) different with values ranging from 92.77 to 114.86 mg/100 g and 66.43 to 57.51 mg/100 g respectively. A significant variation was observed in the sensory qualities between the control and optimized bread. The study revealed that the nutritional and antioxidant properties of the developed functional bread validate its potential health-promoting effects.

OKECHUKWU OBED CHUKWUEMEKA Okechukwu obed chukwuemeka

Tunisian maturity-onset diabetes of the young: a short review and a new molecular and clinical investigation

Introduction/aims: Maturity-Onset Diabetes of the Young (MODY) is a monogenic non-autoimmune diabetes with 14 different genetic forms. MODY-related mutations are rarely found in the Tunisian population. Here, we explored MODY related genes sequences among seventeen unrelated Tunisian probands qualifying the MODY clinical criteria. Materials and methods: The GCK and HNF1A genes were systematically analyzed by direct sequencing in all probands. Then, clinical exome sequencing of 4,813 genes was performed on three unrelated patients. Among them, 130 genes have been reported to be involved in the regulation of glucose metabolism, β-cell development, differentiation and function. All identified variants were analyzed according to their frequencies in the GnomAD database and validated by direct sequencing. Results: We identified the previously reported GCK mutation (rs1085307455) in one patient. The clinical features of the MODY2 proband were similar to previous reports. In this study, we revealed rare and novel alterations in GCK (rs780806456) and ABCC8 (rs201499958) genes with uncertain significance. We also found two likely benign alterations in HNF1A (rs1800574) and KLF11 (rs35927125) genes with minor allele frequencies similar to those depicted in public databases. No pathogenic variants have been identified through clinical exome analysis. Conclusions: The most appropriate patients were selected, following a strict clinical screening approach, for genetic testing. However, the known MODY1-13 genes could not explain most of the Tunisian MODY cases, suggesting the involvement of unidentified genes in the majority of Tunisian affected families.

Mariam moalla Mariam moalla

Antiurolithiatic plants of acanthaceae, amaranthaceae, amaryllidaceae, anacardiaceae, apocynaceae, arecaceae, asparagaceae, aspleniaceae, caesalpiniaceae, capparidaceae, caryophyllaceae, chenopodiaceae, cucurbitaceae, cupressaceae, ericaceae, equiset

Urolithiasis is a common worldwide problem with high recurrence. This review covers Euphorbiaceae twenty (20), Cucurbitaceae eighteen (18), Acanthaceae and Amaranthaceae fifteen (15), Cupressaceae twelve (12), Caryophyllaceae eleven (11), Anacardiaceae ten (10), Amaryllidaceae, Apocynaceae and Asparagaceae nine (09), Ericaceae and Equisetaceae eight (08), Arecaceae and Caesalpiniaceae seven (07), Chenopodiaceae six (06), Aspleniaceae, Capparidaceae and Crassulaceae five (05) plants used globally in different countries. Hopefully, this review will not only be useful for the general public but also attract the scientific world for antiurolithiatic drug discovery.

Dr. Salman Ahmed Dr. salman ahmed

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