The global burden of metabolic disorders, including obesity and type 2 diabetes, necessitates innovative therapeutic strategies. SLU-PP-332, a synthetic agonist of estrogen-related receptor α (ERRα), has emerged as a promising exercise mimetic, demonstrating preclinical efficacy in enhancing mitochondrial biogenesis, insulin sensitivity, and energy expenditure. This brief review synthesizes current knowledge on SLU-PP-332 and related ERRα agonists, highlighting their molecular mechanisms, preclinical outcomes, translational challenges, and ethical considerations. ERRα activation by SLU-PP-332 upregulates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), driving fatty acid oxidation and mimicking exercise-induced metabolic adaptations. However, pan-ERR activity raises concerns about off-target effects such as cardiac hypertrophy and hepatotoxicity. Despite robust preclinical data, clinical translation remains hindered by the absence of human trials and undefined long-term safety. Future research must prioritize isoform-selective agonist design, rigorous clinical validation, and equitable access frameworks.

Mostafa eissa

The development of smart phone technology has lead to denigrate of the phone prepared with many sophisticated features such as sensors. Camera is one of the most extensively used sensors. Although the photographs capture by camera can be shared via Multimedia Message Service (MMS) which allows broadcast of files like photographs, audio and video. A major problem of MMS is, it doesn’t provide adequate safety mechanism. Because of this, the data of the people who wants to conceal confidential information from state-controlled systems that can be easily monitored. Video Steganography is a technique to hide any type of files in any extension into a Video file. The idea proposed in this paper is to embed any kind of data in another file, which is called carrier file. The carrier file must be image video file. Steganography is the art of hiding messages inside other messages such that the very existence of the message is unknown to third party. In this paper, a steganography-based android mobile application that can insert the confidential information into an image, then into a video that can be send it to receiver. Finally we can extract the confidential information from the image in the receiver side.

Dr h shaheen

Purpose – The purpose of this review is to critically analyse the extant research and help readers understand the ways the school-based comprehensive sexuality education (CSE) can contribute towards youth development and urge policymakers to implement nationwide good-quality, scientific, culturally relevant, age-appropriate and holistic school-based CSE. Design/methodology/approach – This literature review has been designed using the extant information available on Google Scholar, Web of Science (WoS) and PubMed. Findings – The findings of this review inform that there is a significant need amongst the youth of the day for good-quality, scientific, culturally relevant, age-appropriate and holistic school-based CSE. Also, the findings suggest that there are significant associations between school-based CSE and youth development. Research limitations/implications – This research paper although draws from extant literature about sexuality education and its delivery across the globe, it applies the sexuality education scenario in India. Practical implications – The findings of this review aim to implicate nationwide policy-level changes to implement CSE in the school curricula. There are more practical behavioural changes that CSE could foster amongst students, which are discussed in the review. Social implications – Due to the behavioural changes that CSE could foster amongst students, it may help in the upbringing of responsible citizens who are free of health complications, who can make independent health related decisions and look after each other in the community. Originality/value – This review is an original contribution from the author. Whilst there is extant literature about CSE and youth development, this article fills the void by investigating the interdependent contributions that both the concepts can make to one another and encourages more research on this topic.

Hari hara sudhan r

The Performance Management System is considered as most important system in organization. HR Analytics in Performance Management helps to understand better what is required among their Employees to increase Productivity and ultimately improves the employee Performance. HR Analytics is a method used to measure and organize information related to employee that give clean insights about the performance and productivity of an employee. It also helps the Organisations to maintain record and analyse information of specific employee with specific skill sets, this helps in cost reduction, optimizing recruitment and improving talent quality. For every organization, their employees are very precious asset. Thus, it is extremely essential to analyse, assess, and predict employee requirements. In this Modern Era measuring the performance of employees in IT Companies is a great task. This paper highlights the importance of Performance management in organisation and its influence on employee’s better performance, job achievement and work life balance.

Js

Abstract: This study was conducted on two groups of broiler , the first consists of 4 replicates of 10 birds and the second of 10 birds as each bird is a replicate in individual cages. The first group were reared on floor during the entire period ,while the second was reared in cages during the period from 2-7 weeks of age. All birds received the same ration with 2859 Kcal/ kg ME and 22% CP as a starter ration, 2995 Kcal/kg ME and 19.19% CP as a finisher ration. The results showed that cage birds had a significantly (P≤0.01) higher body weight , total and daily weight gain at all ages , significantly(P≤0.01) higher total and daily feed and protein consumption , at 2- 4 , 0-4 weeks , feed and protein conversion ratio at 4- 7, 0- 7 weeks. Also cage birds showed a significantly better growth rate at 2- 4 , 0- 7 weeks and less dressing percentage, higher wing percentage while other carcass parts did not differ significantly. The cage birds showed better economic efficiency by 27% comparing to floor birds.

Rafea mohammedtaher khulel

Cystic fibrosis is a challenging disease which creates many complications. The impact caused from cystic fibrosis on an adolescent is a challenging phase for their lives. Negative impacts like the society’s pressure, anxiety and depression are few common reasons that are being unspoken and ignored due to complexity of the disease. This study is aimed to identify the necessary gaps and educate the necessary policy makers and CF center health care team to have a better understanding about the context of the aftermath of cystic fibrosis and enhance better patient care. More over this systematic review also points out the main trends in this field of study. Qualitative study and quantitative are prominently used research methods to gain an understanding the about the gaps in the research. However, there is still a scarcity of quantitative and mixed research methods. Furthermore, limitations such as language, cultural influences were identified whilst going through the analysis. Overall through the information given in the following in this study more information regarding that warrants answers can be identified which will lead to proper care towards the teenagers who suffers from cystic fibrosis

Chanitha pemasena

This paper investigates the deep learning techniques to improve radio resource management (RRM) in vehicular communication network (VCN). In this paper, the deep learning algorithms are highlighted which are used for RRM. Deep learning technique in RRM is basically used to train the model using various algorithms of resource management including network data. Various machine learning tools will be helpful to get best solutions for resource allocation in a large cellular network.

Vartika agarwal

The strategy is a means of establishing the organisation's purpose in terms of priorities for resource allocation, action programs and long term objectives (Grant 2005). Chandler (1962) defines strategy as determining the primary long-term goals of an organisation, the adoption of courses of action, and the allocation of necessary resources. Besides, the strategy also focuses on allocating resources in relation to the organisation and its environment (Schendel & Hatten 1972). The strategy also pertains to the top management's decisions pertaining to its scope and the future direction. Such strategy covers an action plan on the organisation's future, commitments to specific products, services, and the markets.

Zamzam abdelazim

In this article, a systematic flow of contents was provided with regard to the synthesis of Atovaquone 1a on critical examination of the prior-arts. Several patents and study articles were published, disclosing different synthetic methods for the preparation of Atovaquone 1a at various scales. Based on the starting materials used, there are a few one-step, two-step and multi-step synthetic routes were reported with varied yields. In this work, we have put in our sincere effort to collect all the synthetic routes of Atovaquone 1a in detail with distinct and elaborate reaction schemes for a better and collective process clarity. From this review, global researchers will get a platform to re-design or re-work on the synthetic approach of Atovaquone 1a with better atom economy and purity. In addition, the drug commercialization angle could also be looked in during the design stage itself alongside green chemistry concepts. We have done the chronic analysis of study articles to highlight the commercial feasibility of the disclosed synthetic methods. A special emphasis was given to the synthetic routes with process development initiatives towards, recovery/reuse of costly starting materials/reagents/solvents and their feasibility for large scale manufacturing of drug Atovaquone 1a.

Mediterranean journal of pharmacy and pharmaceutical sciences

In an era of rapid technological advancement, the digital divide between rural and urban communities has become increasingly apparent. This study aims to investigate consumer awareness towards cyber security in both rural and urban settings, recognizing its critical importance in safeguarding personal and sensitive information. The study underscores the urgent need for targeted interventions to bridge the digital divide in cyber security awareness. Policymakers, educators, and community leaders must collaborate to implement initiatives tailored to the unique needs of rural populations, including improving access to technology, enhancing digital literacy programs, and fostering a culture of cyber security consciousness. By addressing these disparities, we can strive towards a more inclusive and resilient digital society where all individuals, regardless of their geographic location, are empowered to navigate the digital landscape securely. This research paper delves into the awareness and attitudes of consumers regarding cyber security in both rural and urban settings. With the increasing prevalence of online activities, particularly e-commerce, understanding the level of awareness and concerns about cyber security is crucial. The study analyzes data collected from 100 respondents, examining demographics, online shopping behavior, encounters with security issues, familiarity with safety measures, and sources of information about cyber security. The findings provide insights into the digital divide between rural and urban communities and offer recommendations for enhancing cyber security awareness and education.

Dr. kishor bholane

Background: The legume pod borer, Helicoverpa armigera (Hübner), is one of the most damaging crop pests, including pigeonpea. Host plant resistance is a component of pest management and therefore, we standardize a nylon bag No-Choice Bioassay technique to screen for resistance to H. armigera under field conditions. Methods: Pigeonpea plants were infested with 24 h old 1, 2, 3, 4 and 5 larvae per plant inside the nylon bag. Observations were recorded on pod damage, larval survival, larval weight, pupation, adult emergence, and fecundity after 10 days. Result: Pigeonpea varieties AL-201, H03-41 and PAU-881 exhibited lower pod damage (15.89 to 19.77%) and larval weight (12.02 to 13.82 mg). The expression of resistance to H. armigera was associated with trichome density, pod wall thickness and higher amount of phenolic compounds and condensed tannins. Lower trichome density and thin pod walls and higher amounts of sugars rendered the varieties Paras, Manak and Pussa-992 more susceptible to H. armigera. Nylon bag assay can be used to screen and select pigeonpea cultivars for resistance to H. armigera.

Dr. babu lal jat

Vigna radiata (L.) R. Wilczek, commonly known as Mung bean, is one of the most important pulse crops grown from tropical to sub-tropical areas worldwide. Mung bean is reported to help prevent the loss of nails and hair, reduce the risk of hypercholesterolemia and coronary heart disease, and decrease the absorption of toxic substances. Flavonoids and phenols are reported from this plant. Antioxidant, anti-diabetic and hypocholesterolemic activities are also shown by Vigna radiata

Dr. salman ahmed

Overpopulation is a global problem which affects almost everyone in the globe by reducing the available natural resources in the existence. An epidemiological survey was conducted with the aim to assess the people’s response towards overpopulation and its harms to them. The study was conducted based upon descriptive survey design using interview method. The study comprises 80 people residing in selected rural area. The data was collected based on purposive sampling using checklist. The study reveals that most of the people are residing by doing unskilled work due to unemployment with poor living standard.

Neeraj kumar bansal

Background: Emerging data found that Type 2 diabetes mellitus (T2DM) is associated with Vitamin D deficiency at various frequencies. This study aims to estimate the prevalence of Vitamin D deficiency in T2DM patients in Qatar and the correlation between Vitamin D deficiency and other variables such as dyslipidemia, glycemic control, and microalbuminuria. Methods: This retrospective cross-sectional analytical study was conducted in the medical outpatient clinic at Hamad General Hospital. The study involved adult patients (≥18 years) with T2DM. The study covered patients admitted between January 1, 2018, and July 31, 2018. Ethical approval was obtained from the Medical Research Committee. Results: We recruited 400 subjects with T2DM. Their mean age was 58.97±10.32 years, and the majority were women (52.0%) and Arabs (69.5%). The mean duration of Type 2 diabetes diagnosis was 14.94±8.99 years. The prevalence of Vitamin D deficiency was 29.5%. A comparison between Vitamin D deficiency and non-vitamin D deficiency groups showed a statistically significant difference in terms of fasting blood (FB) sugar (p<0.001), random blood (RB) sugar (p<0.001), hemoglobin A1c (HBA1c) (p<0.001), total cholesterol (P = 0.001), low-density lipoprotein cholesterol (LDL [C]) (p=0.004), high-density lipoprotein cholesterol (HDL [C]) (p<0.001), triglyceride (p<0.001), and urinary albumin excretion rate (UAER) (p=0.007). Data analysis showed that a significant negative correlation was found between Vitamin D level and FB sugar (r=−0.208, p<0.001), RB sugar (r=−0.20, p<0.001), HBA1c (r=−0.260, p<0.001), total cholesterol (r=−0.218, p<0.001), LDL (C) (r=−0.176, p=0.004), triglyceride (r=−0.342, p<0.001), and UAER (r=−0.184, p=0.007). Conclusion: Our study showed a significant correlation between Vitamin D deficiency and the poor control of T2DM, dyslipidemia, and microalbuminuria. The results emphasize the importance of monitoring Vitamin D status in high-risk populations.

Karishma

Trachoma is a Neglected Tropical Disease (NTD) and one of the most common ocular contagious diseases, caused by different serovers such as A, B, Ba ,C of bacterium Chlamydia trachomatis that occurs recurrently. Most infants are adversely affected from chronic keratoconjunctivitis, leading to blindness in later life. Epidemiological studies in 2023 revealed that approximately 115.7 million people were at risk of trachoma, but presently it has been declined to almost 103.2 million. Basically this disease is predominant in least developed or developing nations with high poverty. Preventive measures being implemented by the World Health Organization (WHO) , popularly known as ‘SAFE’ strategy: S for surgery, A for antibiotic dissemination, F for facial cleanliness, and E for environmental improvements. Now-a-days it is effectively and extensively applied; that’s why number of active patients are reduced drastically, but trachoma-free world creation should be the principal and researches will make it possible.

Diptarup mallick

Background: Pioglitazone, a peroxisome proliferator-activated receptor gamma (PPARγ) agonist, has demonstrated potential in managing Alzheimer’s disease (AD); however, its oral administration is limited by systemic side effects such as cardiovascular risks and hepatotoxicity. This study aimed to formulate and evaluate a thermo-adhesive intranasal gel containing pioglitazone, utilizing Poloxamer 407 and Carbomer, as a targeted drug delivery system for AD. Methods: A series of gel formulations was prepared and assessed for gelling capacity, homogeneity, pH, and stability. The solubility of pioglitazone in various solvents was tested, and the optimal thermo-adhesive gel was selected based on gelation at physiological temperature (37°C–39°C). Results: The formulation containing 3 g Poloxamer 407 and 0.8 mg Carbomer successfully transitioned into a gel at body temperature and maintained physical stability over 2 months under accelerated conditions. The pH remained within the acceptable intranasal range (5.7–6.0), and no visual or olfactory changes were observed. Conclusions: The developed thermo-adhesive intranasal gel offers a promising alternative to oral pioglitazone delivery for AD, with the potential for enhanced Central Nervous System (CNS) targeting and reduced systemic side effects. Further toxicity and in vivo efficacy studies are warranted to confirm safety and therapeutic value.

Karishma

This study investigates the access and equity challenges faced by tribal students in higher education institutions in Telangana, India. Despite various governmental initiatives aimed at improving educational outcomes for tribal communities, significant disparities persist. This research employs a comparative analysis across selected universities in Telangana, focusing on enrolment rates, retention, academic performance, and support services tailored for tribal students. Data is gathered through a combination of quantitative surveys and qualitative interviews with students, faculty, and administrators to gain a comprehensive understanding of the barriers and facilitators affecting tribal education. The findings reveal systemic inequities related to socio-economic status, cultural relevance of curricula, and the availability of financial and academic support. Moreover, the study highlights successful practices and policies implemented by certain institutions that promote inclusive education and enhance access for tribal students. The results underscore the need for targeted interventions to create a more equitable higher education landscape in Telangana, ultimately contributing to the empowerment of tribal communities and their representation in the academic sphere.

Dr gedam kamalakar

This document will discuss some crucial operational aspect to the National Agricultural Development Company (NADEC) https://nadec.com.sa/ dairy Milk production company such as how well the inventories within the production system are currently managed, detailed illustration of the critical operations involved within NADEC production system presenting a logical operational flow, identify the two points where the organisation’s delivery system may fail to align its operational performance measures, how a lean approach could be utilised in the production system to reduce the failings potentially and the three key findings discussing the extent to which the lean approach may assist the production system with aligning its operational performance measures

Mohamed sorogy

Good prescription writing is essential for dispensing the right drug formulation and dose. When prescriptions are not legible, inaccurate and do not include complete information, there is a possibility of prescribing errors occurring, which leads to adverse events. Poor handwriting is another important issue that makes the information unclear; especially look-alike drug names that may be confused by the pharmacist. World Health Organization has issued a practical manual for Good Prescribing that includes the essential information that should be included in a prescription. In this study, we attempt to investigate the problem of bad prescribing habits in out-patient prescriptions in Benghazi, Libya. Two hundred seventy-five out-patient prescriptions were collected from two private pharmacies on four consecutive days. These prescriptions were scanned for any errors or missing information depending on the standard criteria established by World Health Organization in its practical manual "Guide to Good prescribing". The collected data were processed and statistically analyzed by using SSPSS to calculate the percentage of missing information. Eleven percent (11.0%) of the prescriptions had no address or name of the prescriber on them while 58.0% had no date written on them and in 21.0% the prescriber did not sign the prescription. The age of the patient was only written on 38.0% of the prescriptions. The name of the medication was not clearly written in 18.0% of the prescriptions, while the dosage form of the medication was not written at all in 18.0% and not clearly written in 20.0% of the prescriptions. The total amount of the prescribed drug was not written in 30.0% of the prescriptions. It is to conclude that prescribers included in this study wrote prescriptions with a lot of missing and unclear information as per WHO guidelines for a good prescribing. This shows the weak attitude of Libyan prescribers toward the different aspects of “Good Prescribing”.

Mediterranean journal of pharmacy and pharmaceutical sciences

Abstract __ Considering the size and relevance of coffee industry to the Ethiopian economy this work presents the design, prototype development, analytical and numerical simulation as well as experimental investigation on an active solar coffee dryer. The solar collector and dryer system configuration has been optimized for minimal pressure drop by incorporating guide vanes and minimizing flow separation tendency using numerical simulation on ANSYS. The effect of air mass flow rate on optimal depth of collector, temperature rise and pressure drop were characterized including the effect of variation in solar insolation using CFD approach. By comparing different dryer configurations based on pressure drop and air flow uniformity, a new dryer configuration prototype was developed. In addition, thermal performance of the solar air heater was evaluated experimentally at three different airflow rates on a collector with corrugated absorber plate and another collector with flat absorber plate. High collector outlet temperature and efficiency were observed in a collector with corrugated absorber plate. The effect of depth of grain, moisture content on wet basis, airflow rate and humidity of air were explored for parametric sensitivity vis-à-vis drying time. Within 5 hours, coffee bean dried from 29% moisture content to 12.3% on a clear sunny day and within 7hours from 19% moisture content to 11.1% on a partially overcast day. Average thermal efficiency of the dryer was found to be 50.5% for clear sunshine day and 36.9% for partial overcast day. A good agreement has been observed between the experimental results and the CFD temperature rise predicted output with a deviation of 7.5%. Analytically predicted drying time compared with experimentally measured drying time within a 12.9% deviation. The cost -to-benefit analysis with a comparative assessment on traditional mode of coffee drying has been done and the payback period is found to be 1.03 years with significant benefits.

Tefera abera