Lycium schweinfurthii is a shrub belonging to the Solanaceae family which widely grows in North Africa and Mediterranean regions. The plant leaves have traditionally been used for gastrointestinal diseases as peptic ulcer in Libya. This study aimed to investigate the effect of Lycium schweinfurthii extract on the central nervous system in mice including anticonvulsant, antidepressant and muscle relaxant activities. The methanolic extract was prepared by fractionation technique. Albino male mice weighing 22 ± 2.0 gm were used and equally divided into equal number and weight for each experiment (n = 6). The best effective pharmacologically dose of 400 mg/kg, i.p. of the methanolic extract was selected to explore the anticonvulsant activity for picrotoxin-induced convulsion in mice (5.0 mg/kg), antidepressant activity of forced swimming test of depression and muscle relaxant action by motor coordination test of hanging wire. Fluoxetine (10.0 mg/kg), imipramine (15.0 mg/kg) and diazepam (5.0 mg/kg) were used as reference compounds. Lycium schweinfurthii extract exhibited a significant prolonged delay in the onset time of induced convulsion and significant decrease in the frequency of convulsion as well as a significant decrease in the duration time of attacks. Pretreatment with flumazenil (2.0 mg/kg) was found to increase the frequency and duration of convulsions without profound change in the onset time produced by Lycium schweinfurthii. For antidepressant activity, the plant leave extract significantly decreased immobility time duration without a muscle relaxant effect. The results suggest that the methanolic extract of Lycium schweinfurthii leave has anticonvulsant and antidepressant-like activities without any muscle relaxant effect in mice. Thus, Lycium schweinfurthii may have a neuropharmacological potential use in human.

Mediterranean journal of pharmacy and pharmaceutical sciences

The cross line movement according to the two labor and products is the thing to take care of in the present worldwide economy. Worldwide exchange labor and products has for some time been a standard, for different advantages that gather from it. There have been numerous respective and multilateral arrangements comparable to cross line exchange dealings. The development of administrations area that decidedly influences the everyday daily routine and guidelines of experiencing or personal satisfaction. The World Trade Organization (WTO), of which in excess of 156 nations are individuals, has an understanding according to global administrations exchange. The General Agreement on Trade in Services (GATS) is the WTO's arrangement that administers exchange 12 sorts of administrations, including 'instruction administrations.Each WTO part that proposes to change its 'advanced education administrations' area to outline the 'responsibilities' by specifying certain conditions or restrictions with respect to its strategy on such progression. Contingent upon certain public or provincial targets and the states of interest and supply of advanced education, every part would set down various types of conditions while changing the area to unfamiliar instructive foundations. One of the basic inquiries or issues in such manner would be corresponding to the sort of college to be permitted to set up its grounds or branch or in any case offer training administrations. The inquiry raised here is should WTO individuals from Pro training Services Liberalization permit Foreign Private Universities or Foreign Public Universities?

Dr gedam kamalakar

The novel coronavirus pandemic is affecting the whole world and it is predicted that the process will continue for a long time. The health, economic and social problems caused by this process have greatly affected women as well. In addition to the problems endured by the general population, women are facing additional challenges involving their reproductive health, pregnancy, childbirth and postpartum period. Women are trying to deal with a range of concerns, from difficulties in accessing family planning services to being unable to meet their own basic reproductive health needs. Under the pandemic conditions, it has become increasingly difficult for social services to respond sensitively to women's particular needs. The needs of coronavirus patients take precedence, and the women’s needs remain in the background. Women are facing stress, anxiety, fear, as well as disease. So, midwifery practices need to be revised to adapt to the pandemic conditions. This revision must involve not only technical issues but also psychosocial adjustments. Women have been demanding home births on social media, and this is a subject that require some legal regulations. Respect for women's birth is one of their most fundamental rights. National criteria should be developed to accommodate the support structures needed for a home birth. The social support that midwives offer women during pregnancy, childbirth and the postpartum period, play a key role. Since it is important to increase the awareness of midwives in this regard, this article deals with women's needs for social support and possible midwifery approaches for supporting women through their pregnancy, childbirth, and the postpartum period.

Reyhan aydin doğan

An attempt was made for screening of salt tolerant against sodium chloride (NaCl) salt and growth promotion efficacy of eight different phosphate solubilizing bacterial (PSB) isolates under in vitro conditions. An efficient isolate which exhibited maximum phosphate solubilization, salt tolerant, Indole-3-Acetic Acid (IAA) production and root colonization potential in maximum concentration of NaCl (7%) was identified as Bacillus cereus based on 16S rRNA sequencing. It was recorded that highest phosphate solubilization in 7% NaCl concentration (70% and 374 μg/mL) in agar plate and broth assay respectively. IAA production was observed to be decreased when salt concentration increases, the isolate showed significant amount of IAA in normal culture media without amendment of NaCl (74.94 μg/mL) and at 7% gradual decrease of IAA production was observed (30 μg/mL). Maximum colonization of isolate in the roots of Zea mays was also observed in the study.

Dr. saranya devi k

Background: Parkinson’s disease (PD) is one of the most common, disabling neuro-degenerative disorders. The disease has a significant clinical impact on patients, families, and caregivers through its progressive degenerative effects on mobility and muscle control. Available treatments for PD have varied results. Although there are anecdotal reports of improvement with Homoeopathy, there is a dearth of literature concerning usefulness in management of PD Objectives: To assess the usefulness of ultrahigh dilution of Zinc in the management of PD. Methods: A case of PD under standard care and refractory to treatment visited Out- Patient Department and was assessed with and Unified Parkinson’s Disease Rating Scale (UPDRS). As per the classical Homoeopathic guidelines Zincum metallicum 200 was prescribed after Repertorization. Results: UPDRS total score of 112 at baseline turned to 40 at the end of 1 year and 7 at the end of two years, in spite of reduction in the conventional medicines. Patient was on Stage 3 of Modified Hoehn and Yahr staging at the baseline and turned to Stage O in duration of 21 months. SEADL score has turned from 40% to 100%. Conclusion: Homoeopathic medicine Zincum met. is a valuable adjuvant in the management of Parkinson’s disease.

Dr deepthi gilla

Inclusive education (IE) is a new approach towards educating the children with disability and learning difficulties with that of normal ones within the same classroom. It seeks to address the learning needs of all children with a specific focus on those who are vulnerable to marginalization and exclusion. It implies all learners – with or without disabilities being able to learn together through access to common schools and community educational setting with an appropriate network of support services. This is possible only in flexible education system that includes the needs of different types of learners and adapts itself to meet their needs. Inclusive Education addresses the diverse needs of all learners by reducing barriers inside schools. It is a process of strengthening the capacity of the education system to reach out to all learners. This educational approach provides all students greater opportunities for academic and social achievement. This includes opportunities to participate in the full range of social, recreational, arts, sports, music, day care and afterschool care, extra-curricular, faith based, and all other activities. Inclusive education argues that all children irrespective of the nature and degree of disability should be educated in general schools with non-disabled children. The schools and classrooms operate on the idea that, with right amount of support, students with disabilities can be as competent as students without disabilities.

Kamal singh

Purpose: To study the outcome of therapeutic keratoplasty in severe microbial keratitis cases otherwise advised evisceration. Methods: A retrospective, single-center clinical audit included 28 patients with severe microbial keratitis presenting from April 2014 to April 2016. Patients with microbial keratitis either affecting more than 2 quadrants of the limbus and/or cases with infections involving more than 180 mm2 of the cornea who were advised evisceration by more than one ophthalmologist were included. Cases with endophthalmitis were excluded. At 3 months, the outcome was “success” if resolution of infection occurred without recurrence and evisceration was not required. Success was termed “complete” if best vision was 6/24 or better and “partial” other- wise. The outcome was termed a “failure” if infection recurred in the graft or the eye was eviscerated. Results: Mean age of the patients (male:female, 17:11) was 49.5 years, and the mean duration of symptoms before surgery was 28.6 days. Evisceration was required in 2/28 cases. The outcome was “success” in 22/28 cases (78.6%)—complete (10/22); partial (12/22) —and “failure” in 6/28 cases. The outcome was poorer in general in fungal keratitis (n = 16) than bacterial keratitis (n = 7). Conclusions: Primary evisceration is best avoided in infections limited to the anterior segment. Even in hopeless cases, every eye deserves a fair chance.

Dr. ashwani kumar ghai

The objective of this research was to investigate the effect of initial chick weight at the first day of the hatch on subsequent performance of Iraqi local chickens. 150 unsexed chicks of local chickens weighted at first day of hatch then divided to five groups (A, B, C, D, E) according to the initial weight (26.4, 31.89, 36.38, 41.09, 46.91) gm, the birds were reared in a wooden cage consist of individual compartments with dimensions (30×30×40) cm, The feed and water was available adlibitum, The birds and feed weighted weekly by sensitive balance. The result shows that initial weight had a significant effect on body weight, weight gain, feed and protein consumption, and growth rate but not significant on feed and protein conversion, where group E showed the best results, The relationship between initial body weight and productive traits were studied and the prediction equation of productive traits depending on initial weight shows highly significant

Rafea mohammedtaher khulel

Radio resource allocation in VCN is a challenging role in an intelligent transportation system due to traffic congestion. Lot of time is wasted because of traffic congestion. Due to traffic congestion, user has to miss their important work. In this paper, we propose radio resource allocation scheme so that user can utilize their time by taking the advantage of subscription plan. In this scenario, multitype vehicle identification scheme from real time traffic database is proposed, its history will match in transport database and vehicle travelling history database. Proposed method indicates 95% accuracy for multitype vehicle detection. Subscription plans are allocated to the user on the basis of resource allocation, scheduling, levelling and forecasting. This scheme is better for traffic management, vehicle tracking as well as time management.

Vartika agarwal

Emesis, also known as nausea and vomiting, are common symptoms associated with ingestion of toxicants, drug side effects, advanced terminal diseases such as cancer and postoperative procedures. Emesis is mediated through the coordinated action of central and peripheral regulatory centres that involve receptors including dopamine Type 2, serotonin, muscarinic cholinergic, histamine, cannabinoids and NK-1 receptors. Many anti-emetic drugs targeting these receptors are currently in use, but they also cause undesirable side effects such as excessive sedation, hypotension, dry mouth, dysphoria, hallucinations and extrapyramidal signs. This review highlights the pharmacological mechanism of emesis, current antiemetic drugs, and a detailed analysis of in vitro and in vivo anti-emetic bioassay models. The pharmacology of crude natural products extracts and purified anti-emetic compounds (cannabinoids, chalcones, diarylheptanoids, flavonoids, hydroxycinnamic acids, lignans, phenylpropanoids, polysaccharides, saponins, terpenes and glycosidic derivatives) are also systematically presented with their mechanism of action. The potential of natural products as sources of new clinically proven anti-emetic drugs is discussed.

Dr. salman ahmed

भारतीय मध्यकालीन समाज और संस्कृति की समझ रखने और समझने की कोशिश करने वाले हरेक अध्येता की नज़र इस ओर जाती है कि बाज़ार भक्तिकालीन कवियों के बात करने का एक ख़ास बिन्दु रहा है। जहाँ ये कवि बाज़ार को सबसे अधिक जनतांत्रिक जगह के रूप में प्रस्तुत करते रहे हैं, चाहे वे कबीर रहे हो रैदास हो या फिर तुलसी। ये कवि हमें होशियार भी करते हैं कि बाज़ार में सारी भौतिक चीजें बिक रही हैं आप उन्हें खरीद सकते हैं मगर प्रेम आप नहीं खरीद सकते। ये कवि प्रेम की लगातार वक़ालत करते है। इनके पास दुनिया को खूबसूरत बनाने का एक ही रास्ता है -प्रेम। वे बताते हैं कि कैसे ये भौतिक चीजें मनुष्य के प्रेम को ब्रह्म यानी ज्ञान या मानवता के रास्ते में रोड़ा बन जाती हैं। साथ ही कैसे भौतिक चीज़ें आज अपनी पाँव तेजी से पसारती जा रही हैं।

Manish patel

Pneumonia is an acute pulmonary infection that can be caused by bacteria, viruses, or fungi. It infects the lungs, causing inflammation of the air sacs and pleural effusion: a condition in which the lung is filled with fluid. The diagnosis of pneumonia is tasking as it requires a review of Chest X-ray (CXR) by specialists, laboratory tests, vital signs, and clinical history. Utilizing CXR is an important pneumonia diagnostic method for the evaluation of the airways, pulmonary parenchyma, and vessels, chest walls among others. It can also be used to show changes in the lungs caused by pneumonia. This study aims to employ transfer learning, and ensemble approach to help in the detection of viral pneumonia in chest radiographs. The transfer learning model used was Inception network, ResNet-50, and InceptionResNetv2. With the help of our research, we were able to show how well the ensemble technique, which uses InceptionResNetv2 and the utilization of the Non-local Means Denoising algorithm, works. By utilizing these techniques, we have significantly increased the accuracy of pneumonia classification, opening the door for better diagnostic abilities and patient care. For objective labeling, we obtained a selection of patient chest X-ray images. In this work, the model was assessed using state-of-the-art metrics such as accuracy, sensitivity, and specificity. From the statistical analysis and scikit learn python analysis, the accuracy of the ResNet-50 model was 84%, the accuracy of the inception model was 91% and lastly, the accuracy of the InceptionResNetv2 model was 96%.

Dr. chandrashekhar uppin

The study was carried out to evaluate the effects of thermal processing treatments on nutrient and antinutrient contents of African yam bean seed flours. The African yam bean seeds were sorted, cleaned and divided into five equal lots of one kilogram each. Four lots were processed into boiled, blanched, roasted and autoclaved African yam bean flours, while the last lot was processed raw and used as control. The flour samples obtained were analysed for proximate, mineral, vitamin and antinutrient contents using standard methods. The proximate composition of the samples revealed that the flours had a range of 6.14-11.24% moisture, 8.18-14.37% crude protein, 3.06-4.61% fat, 2.04–3.32% ash, 3.18–3.56% crude fibre, 62.90–76.98% carbohydrate and 350.57–368.50 kJ/100g energy, respectively. The mineral composition of the samples showed that the flours contained 128.81–174.16 mg/100g calcium, 88.86–212.20 mg/100g, potassium, 134.71–166.77 mg/100g phosphorus, 89.17 – 122.76 mg/100g, magnesium, 14.28–18-11 mg/100g iron and 3.24–5.59 mg/100g zinc, respectively. The vitamin composition of the flours were 1.15–1.37 mg/100g ascorbic acid, 1.15–135 mg/100g thiamine, 1.19–1.55 mg/100g niacin, 1.34–1.85 mg/100g riboflavin, 1.09–1.29 mg/100g folic acid, 1.37–1.95 mg /100g vitamin A and 1.27–1.66 mg/100g vitamin E, respectively. The results showed that the roasted and autoclaved African yam bean flours generally had higher crude protein, fat, ash, crude fibre, mineral and vitamin contents than the boiled and blanched flour samples compared to the raw sample. The antinutrient composition of the flours also showed that the levels of trypsin inhibitor activity, tannin, phytate, oxalate, saponin and haemagglutinin of the samples were significantly (p<0.05) reduced by boiling, autoclaving roasting and blanching treatments compared to the raw sample. However, the study revealed that the processed African yam bean flours have the potentials to be used as nutrient dense ingredients in the preparation of a wide range of food products than the raw sample especially in both underdeveloped and developing countries where the problems of protein-energy malnutrition and micronutrients deficiencies are prevalent.

Okechukwu obed chukwuemeka

Moringa oleifera, a very important healthful plant, is one amongst the foremost wide cultivated species of the family Moringaceae. It's extremely valued from past as a result of its large healthful properties. Moringa oleifera, native to India, grows within the tropical and climatic zone regions of the globe. It's commonly called drumstick tree or horseradish tree. Moringa will face up to each severe drought and gentle frost conditions and, therefore wide, cultivated across the globe. With its high alimentary values, each part of the tree is appropriate for either nutritional or commercial purposes. The leaves are rich in minerals, vitamins and alternative essential phytochemicals. Extracts from the leaves are useful in treatment of anemia, enhance breast milk in wet mothers. It's used as a potential antioxidant, anti-cancer, anti-inflammatory, anti-diabetic and antimicrobial agent. Thus, this study was aim to investigate the phytoconstituents from ethanolic and aqueous extracts of the Moringa oleifera cultivated in Libya and to assess its anti-bacterial and anti-diabetics activity. The phytochemical investigations of these extracts of Moringa oleifera revealed the presence of alkaloids, carbohydrates, flavonoids, saponins, steroids, tannins and phenolic compounds. The antibacterial activity of cold and hot extraction of methanolic and water extracts of Moringa oleifera by using the well diffusion method were assessed. Results revealed that there was a profound antibacterial activity of the studied Moringa oleifera against representatives of Gram-positive bacteria. After in vitro evaluation of anti-hyperglycemic properties of the ethanolic extract of Moringa oleifera by testing its capacity to inhibit α-amylase activity, the methanolic extract exhibited inhibitory effect on the α-amylase enzyme.

Mediterranean journal of pharmacy and pharmaceutical sciences

Higher education is leadership education. The values and virtues practiced in universities heavily influence the future leaders. Many institutions of higher education simultaneously show excellence in academic subjects, are green campuses with manifold ethics curricula, are active members in community engagement, and also are adept in providing value orientation to all stakeholders. It is universally felt that the status of teaching profession requires to be raised to ensure its dignity and integrity. Accordingly, it is considered necessary that there should be a code of ethics which may be evolved by the teaching community itself for its guidance. There are five major areas of professional activities which encompass the work of a teacher. For each of these areas certain principles have been identified to serve as guidelines for teacher’s conduct. HUMAN VALUES Basic human values refer to those values which are at the core of being human. The values which are considered basic inherent values in humans include truth, honesty, loyalty, love, peace, etc. because they bring out the fundamental goodness of human beings and society at large.

Kamal singh

The wet coating of anhydrous borax powders with stearic acid (SA) to reverse their inherent hydrophilic surface properties was investigated. The coating procedure was based on the results from a previous study that revealed that the stearic acid solution (2 wt. % SA) mixed for 60 minute at 750 rpm on the magnetic stirrer was sufficient for the surface modification of anhydrous borax. For the experiments, stearic acid powders were first dissolved in water at 80 °C. The mixture obtained by adding anhydrous borax powders to this solution was vigorously mixed on a magnetic stirrer to initiation and completion the surface modification. Each of these solutions was then filtered using a filter paper to separate the undissolved particles, and the residue on paper was dried at 50 °C for 48 h until constant weighing was obtained. Wettability has been accepted as a key parameter for success in wet coating treatment. This parameter gained via the experimental characterization technique was used for an evaluation of the powder properties. The degree of wettability of anhydrous borax powders was measured and compared both after their surfaces were coated with stearic acid and after they were treated with water for a certain period of time in an aqueous environment. The stearic acid coating made the powder hydrophobic and this property was highly preserved after washing.

Journal of characterization

Background: E-waste, is the waste generated from used electrical and electronic devices that are no longer fit for their original intended use. Currently e-waste comprises more than 5% of total municipal waste flow, equivalent to 20-50 million tonnes annually worldwide. In 2014, Nigeria generated about 219 kilo tonnes of e-waste. The study aimed to increase public awareness on the need for proper management of e-waste because of its hazardous nature. Methods: This was a cross-sectional study in Enugu West Senatorial District of Enugu State comprising Oji-River, Ezeagu, Udi, Awgu and Aninri Local Government Areas with a population of 980,988. An adaptation of the UNEP, EMPA and Basel convention questionnaire, administered to 400 households was used for data collection. Results: The potential e-waste generation in the study area was 0.05 kg per inhabitant. 76% of the households were aware of the hazards of e-waste. 64% were willing to give out their e-waste to waste collectors. Only 26% of the e-waste were collected with the general waste. The correlation between awareness of the hazards of e-waste and willingness of the households to give out their e-waste was positive, moderate, and insignificant (r= 0.43, p=0.47). Conclusions: Although 76 per cent of the households were aware of the hazards of e-waste, with 64% willing to give out their e-waste, only 26% of the e-waste were eventually collected together with the general waste. There is a need to create a separate e-waste collection system.

Emmanuel umegbolu

Youth entrepreneurship contributes to the social, cultural, and economic development of society, especially in many developing countries. The idea of encouraging young people to start businesses for a variety of reasons is now widely encouraged. However, there are many challenges and doubts faced in starting a business particularly after the Covid-19 is over. Therefore, the community service was carried out by lecturers at Business School, Universitas Pelita Harapan Medan Campus, providing the onsite seminar and training to 70 high school students at Santo Nicholas School in February 2023. The purpose of the community service was to encourage the students to plan their business projects by presenting data and information on the latest trends and issues in entrepreneurship and finance, as well as conducting one-to-one sessions with the students. Most of the students were enthusiastic throughout the activities resulting in several business plans and proposals being created at the end of the community service. It is implied that young people are indeed motivated to begin their entrepreneurship journey and school is the right place for them to acquire the necessary knowledge and skills. Teachers and parents are suggested to continue to assist the students by providing the commitment and funding required to begin and sustain the business.

L

Nuclei segmentation plays an essential role in histology analysis. The nuclei segmentation in histology images is challenging in variable conditions (clinical wild), such as poor staining quality, stain variability, tissue variability, and conditions having higher morphological variability. Recently, some deep learning models have been proposed for nuclei segmentation. However, these models rarely solve the problems mentioned above simultaneously. Most of the information in Hematoxylin and Eosin (H&E) stained histology images is in its channel, and the remaining information is in the spatial domain. We observed that most problems could be solved by considering channel and spatial features simultaneously, e.g., the spatial and channel features provide the solution to the morphological variability and staining variability, respectively. Therefore, we propose a novel spatial-channel attention-based modified UNet architecture with ResNet blocks in encoder layers. The UNet baseline preserves coarse and fine features, thus proving the solution to the tissue variability. The proposed method significantly improves the segmentation performance compared to the state-of-the-art methods on three different benchmark datasets. We demonstrate that the proposed model is generalized for 20 cancer sites, more than any reported literature. The proposed model is less complex than most state-of-the-art models. The impact of the proposed model is that it will help improve further procedures such as nuclei instance segmentation, nuclei classification, and cancer grading.

Ibtihaj ahmad

The rate of oxygen consumption was measured in mercury chloride treated freshwater fish, cyprinus carpio for 96h and compared to control group. The present investigation showed that average oxygen rate was decreased in all treated animal as compared to controlled group. Behavioural changes was also recorded in both concentration. The behavioural alterations observed like surfacing, erratic movement, increased mucous secretion, decreased opercular movement and loss of balance. The present study revealed that, mortality rate increased with increases in concentration.

.vijay digambar suryawanshi