Iatrogenic splenic infarction is a rare clinical entity that can result from various abdominal surgical and invasive procedures. We report a case of iatrogenic splenic infarction in a 29-year-old female who presented with hemoptysis and was found to have pulmonary sequestration. During the embolization of the anomalous artery supplying the pulmonary sequestration, she developed severe pain and was found to have a splenic infarction, caused by a part of the coil that dislodged during the procedure. The patient showed good response to conservative management and was discharged in good condition.

Karishma

Numerous health and social relationship problems, namely an increased risk of contracting HIV, mortality, crime, unemployment and impaired interpersonal relationships, are related to drug dependence, with opioids at the helm. For this reason, opioid addiction is considered a major public health problem [1] and is characterized as a ‘chronic relapsing disease’ and is a major concern for public health, as are drug and alcohol addictions [1, 2]. In addition to social support and psychotherapy, treatment of opioid dependence relies on medication intake. The three main opioid-dependence treatment categories include opioid agonists, opioid antagonists, and non-opioid medications. Naltrexone hydrochloride (API), one of the most commonly used medications relies on an opioid antagonist. It reduces opioid cravings, it can be administered outside the hospital setting and cannot be abused [3]. However, during treatment several patients often forget to take a dose, doubling the next dose to compensate. In some cases, this finding in the therapeutic levels not being reached, while in other cases undesired (side) effects appear. For this reason, especially in the case of long-term treatments of numerous diseases, an extended dosing interval is recommended, so that the patient receives the drug, only once a day, instead of two or three times a day.

Mediterranean journal of pharmacy and pharmaceutical sciences

In this article, we establish the exact wave solutions of the Boussinesq equation and the (2 + 1)-dimensional extended shallow water wave equation by applying the new generalized (G'/G)-expansion method. When the condition of the fluid is such that the horizontal length scale is much greater than the vertical length scale, the shallow water equations are mostly suitable. In Ocean engineering, Boussinesq-type equations are commonly used in computer simulations for the model of water waves in shallow seas and harbors. We explained the new generalized (G'/G)-expansion method to seek further general traveling wave solutions of the above mentioned equations. The traveling wave solutions attained by this method are exposed in terms of hyperbolic, trigonometric and rational functions. The shape of the obtained solutions are bell shaped soliton, kink soliton, singular kink soliton, singular soliton, singular periodic solution and compaction. This method is very influential mathematical tool for extracting exact solutions of NLEEs which frequently arise in mathematical physics, engineering sciences and many scientific real world application fields.

Md khorshed alam

Heavy metals and trace elements such as lead (Pb), mercury (Hg), cadmium (Cd), arsenic (Ar), nickel (Ni), Chromium (Cr), cobalt (Co), copper (Cu), mercury (Mg), iron (Fe) and aluminum (Al) are detected in various types of herbal cosmetics. Heavy metals and elements can accumulate at high concentrations causing serious risks to human health when consumed. In this study, the levels of potential heavy metals of Pb, Ar, Cd, and Ni were quantitatively determined using atomic absorption spectroscopy. Samples of Henna leaves, Henna paste, Khol stones and baby Talcum powder were collected randomly from different public markets of Tripoli city. The results were evaluated by using different international guidelines, US-FDA, EU regulation, German (BVL), World Health Organization (WHO) and Canadian Guidelines. Because of controversial global guidelines, the study urgent the ultimate need for setting up harmonized minimum levels of heavy metals in cosmetics that could be applicable worldwide. Generally, the presence of a higher concentration of some of the studied heavy metals was observed, and the effect of these heavy metals at higher levels will be more harmful to consumer health after prolonged usage. In conclusion, nationally, the need for developing and updating the national specification for cosmetics by the Libyan National Centre for Standardization and Metrology (LNCSM) to protect consumers from more catastrophic cosmetic hazards is urgently required.

Mediterranean journal of pharmacy and pharmaceutical sciences

Cancer is one of the most severe medical conditions in the world, causing millions of deaths each year. Chemotherapy and radiotherapy are critical treatment approaches, but both have numerous adverse health effects. Furthermore, the resistance of cancerous cells to anticancer medication leads to treatment failure. The rising burden of cancer requires novel, efficacious treatment modalities. Natural remedies offer feasible alternative options against malignancy in contrast to available synthetic medication. Selective killing of cancer cells is privileged mainstream in cancer treatment, and targeted therapy represents the new tool with the potential to pursue this aim. The discovery of innovative therapies targeting essential components of DNA damage signalling and repair pathways, such as ataxia telangiectasia mutated and Rad3-related Checkpoint kinase 1 (ATR-CHK1), has offered a possibility of significant therapeutic improvement in oncology. The activation and inhibition of this pathway account for chemopreventive and chemotherapeutic activity, respectively. Targeting this pathway can also aid in overcoming the resistance of conventional chemo- or radiotherapy. This review enlightens the anticancer role of natural products by ATR-CHK1 activation and inhibition. Additionally, these compounds have been shown to have chemotherapeutic synergistic potential when used in combination with other anticancer drugs. Ideally, this review will trigger interest in natural products targeting ATR-CHK1 and their potential efficacy and safety as cancer-lessening agents.

Dr. salman ahmed

Purpose: To study the outcome of therapeutic keratoplasty in severe microbial keratitis cases otherwise advised evisceration. Methods: A retrospective, single-center clinical audit included 28 patients with severe microbial keratitis presenting from April 2014 to April 2016. Patients with microbial keratitis either affecting more than 2 quadrants of the limbus and/or cases with infections involving more than 180 mm2 of the cornea who were advised evisceration by more than one ophthalmologist were included. Cases with endophthalmitis were excluded. At 3 months, the outcome was “success” if resolution of infection occurred without recurrence and evisceration was not required. Success was termed “complete” if best vision was 6/24 or better and “partial” other- wise. The outcome was termed a “failure” if infection recurred in the graft or the eye was eviscerated. Results: Mean age of the patients (male:female, 17:11) was 49.5 years, and the mean duration of symptoms before surgery was 28.6 days. Evisceration was required in 2/28 cases. The outcome was “success” in 22/28 cases (78.6%)—complete (10/22); partial (12/22) —and “failure” in 6/28 cases. The outcome was poorer in general in fungal keratitis (n = 16) than bacterial keratitis (n = 7). Conclusions: Primary evisceration is best avoided in infections limited to the anterior segment. Even in hopeless cases, every eye deserves a fair chance.

Dr. ashwani kumar ghai

Stability studies ensuring the maintenance of product quality, safety and efficacy throughout the shelf life are considered as pre-requisite for the acceptance and approval of any pharmaceutical product. These studies are required to be conducted in a planned way following the guideline issused by ICH, WHO and or other agencies. Importance of various methods followed for stability testing of pharmaceutical products, guideline issued for stability testing and other aspects related to stability of pharmaceutical products have been presented in a present review.

Prachi barbhaiya

Scheduling is the need of every project. Without scheduling, projects don’t fulfill time constraints, go over spending plan. It is a process utilized by teams to organize and structure their resources so the tasks they need to complete are scheduled based on availability and capability. This process is more beneficial if it is required to allocate and assign task to the resources without allocating their schedules. This paper reviews different types of network scheduling techniques, which are used to schedule a task. These techniques are very effective and help us to preplan the whole scheduling process

Vartika agarwal

Background: Glaucoma is a group of disorders that can lead to irreversible vision loss if untreated. It affects individuals across all ages, genders, and ethnicities, with intraocular pressure (IOP) being the only modifiable risk factor. Regional studies highlight variations in the prevalence of glaucoma subtypes, underscoring the need for population-specific data to guide effective prevention and treatment efforts. This study aimed to explore the clinical characteristics and patterns of glaucoma patients in a tertiary care setting in Bangladesh. Methods: This was a hospital-based cross-sectional study, conducted from January to December 2023 at the Glaucoma Department of Deep Eye Care Foundation. A total of 2,172 individuals aged 20 years and above were conveniently selected as the study population. After explaining the study objectives, written informed consent was obtained from all participants. Ethical approval was obtained from the institutional review board of the Deep Eye Care Foundation. Data analysis was performed using the Statistical Package for Social Sciences (SPSS), with a P-value of less than 0.05 considered statistically significant. Results: The study population predominantly consisted of middle-aged and older adults, with a slightly higher proportion of females than males. Most participants were housewives, followed by farmers. A majority resided in rural areas rather than urban, and only a negligible number reported a family history of glaucoma. More than half of the patients presented with reduced visual acuity. The average IOP was nearly similar in both eyes. Most cases showed bilateral involvement of glaucoma. The predominant types of glaucoma were primary angle-closure suspects (PACS) and primary open-angle glaucoma (POAG). The main treatment approaches included beta-blockers and laser peripheral iridotomy, while a notable proportion of patients were kept under observation. Conclusions: Bilateral involvement and reduced visual acuity were common, with PACS and POAG being the predominant subtypes. This study offers unique insights into the demographic and clinical profile of glaucoma in rural communities, emphasizing the need for communitybased screening, gender-sensitive eye care, and early detection to reduce visual disability.

Karishma

Plant secondary metabolites refer to various chemical compounds that plants produce. Still, they are not directly involved in essential growth processes like primary metabolites (such as sugars, amino acids, and lipids). The term "secondary metabolite" has generated controversy, as it implies these compounds are of minor importance to plants. "Special metabolites" may be a more suitable term. These metabolites protect plants from both abiotic and biotic stress. The vast diversity of plant secondary metabolites showcases plants' incredible adaptability and versatility, providing an arsenal of chemical tools to defend against herbivores, protect from pathogens, attract pollinators and seed dispersers, adaptability and thrive in environmental interactions. Plants can, therefore, survive under less-than-ideal conditions. The profound impact of plant secondary metabolites highlights the intricate relationship between plants and humanity, opening doors to innovative applications with far-reaching implications.

Dr. salman ahmed

Cardiovascular diseases represent a formidable global health challenge, standing as the foremost cause of both mortality and morbidity. Atherosclerosis and myocardial infarction, as primary contributors to this epidemiological burden, underscore the urgent need for effective therapeutic interventions with minimal side effects. Natural compounds derived from plants have emerged as promising candidates, given their enhanced efficacy and reduced adverse effects. Phytochemicals, in particular, have garnered attention for their potential as alternative therapeutic agents. This review delves into the cardioprotective potential of pinocembrin (5,7-Dihydroxy flavanone), a compound extracted from various plants and honey. Renowned for its antioxidant and anti-inflammatory properties, pinocembrin demonstrates significant cardioprotective effects through the modulation of diverse signaling pathways. Atherosclerosis and myocardial infarction entail intricate cellular mechanisms involving oxidative stress, inflammatory responses, cellular remodeling, and programmed cell death. Pinocembrin, by targeting key factors within these pathways, exhibits cardioprotective actions. While existing research underscores its effectiveness, further investigations are warranted to elucidate the impact of pinocembrin on additional cardiovascular conditions and explore novel molecular targets, thus paving the way for future advancements in therapeutic interventions.

Brinda elangovan

During Movement Control Order (MCO) of COVID-19, many information has been disseminated through both traditional and social media. Some of that information was credible and came from reliable sources while other information was fake and included misinformation, disinformation, and infodemic. The people needed credible information rather than fake one in this critical time. This study aimed to explore the credibility of media, information sources, the main issues, and preferred communication patterns and method of works perceived by Malaysians during MCO. A total of 300 questionnaires were distributed, and 210 were returned. The results of this study showed that the majority of respondents 69% relied on new media as their main source of information compared to 30.9% who relied on traditional media. However, a total of 64.8% of respondents considered traditional media as more credible and accurate compared to 35.2% for new media. Additionally, the main concerns and issues followed by respondents on media were health, economic, social, education and others. Finally, a total of 55.7% preferred face to face communication compared to 44.3% who preferred online communication. A total of 51% of respondents preferred to work from the workplace or office compared to 49% who preferred to work from home. Television played a significant role during the pandemic period due to its high credibility as perceived by Malaysians. The main intriguing implication of this study is considering the traditional media as more credible than social media by the Malaysians although the social media was their main source of information.

Mohammed fadel arandas

This paper aims to study the restructuring and change management of SARHS, which in turn will be accompanied by some complex, difficulties and discussions that may include personnel emotion, which must be taken into account. We will guide SARHS managers by conducting a comprehensive study of majority factors that will affect the success of the process, considering and covering all views. Which will result in the dismissal of some employees and the closure of their jobs permanently in the new job structure. The study will include many theories, models and justified recommendations to be followed to ensure a successful and safe restructuring and management change free from unresolved impediments and difficulties that could lead to a setback. Finally, restructuring is not a result but the beginning of a new process

Mohamed sorogy

The Internal Medicine Residency Program at Hamad Medical Corporation (HMC) is accredited by the Accreditation Council for Graduate Medical Education–International (ACGME-I). Upon completion, residents are awarded both the Arab Board and Qatari Board certifications. This four-year program involves rotations across general internal medicine and its subspecialties in both inpatient and outpatient settings. This article aims to analyze the teaching theories and methods observed during internal medicine residency training. An essential benefit of learning theories is the ability to articulate educational plans and objectives more precisely. Furthermore, integrating theory into practice strengthens improvement programs and facilitates their evaluation. [1] The following sections describe and analyze the educational process as experienced throughout the residency program from resident perspective.

Karishma

PHYSICO-CHEMICAL ANALYSIS OF RHIZOSPHERIC SOIL OF MAIZE (Zea mays L.) AND ITS EFFECTS ON MAIZE DISEASE INCIDENCE (IN VIVO) IN KARNATAKA

Veerabhadraswamy al

Accurate diagnosis of the cause of acute or chronic kidney dysfunction may require a percutaneous kidney biopsy (PKB). Unfortunately, the invasive nature of the procedure can lead to potential complications that may discourage the KBs. Lack of appropriate communication skills, experienced personnel and equipment, and high procedure costs can negatively impact complication rates and the frequency of conducted KBs. This nonsystematic review assesses KB procedures, indications, contraindications, complications, post-KB monitoring time, and cost. We looked for reviews and original articles published between January 2010 and Jan 2025 on Google, Google Scholar, and PubMed. Different keywords, phrases, and sentences include PKB, renal biopsy, native PKB, ultrasound guide, CT-guided, PKB, allograft PKB, and PKB procedures. KB makes histopathological and immunohistological diagnosis possible, which are necessary for diagnosis and treatment. It is often used despite the known complications. KB and other biochemical assays have tracked transplant rejection and antirejection drugs. Automatic gun spiral needles sizes 14 and 16 capture enough samples with fewer complications than gauge sizes 18 and 20. KB cost is another issue, especially in low-income areas, and deserves additional study.

Karishma

The present study deals with the phytochemical analysis and evaluation of antibacterial activity of hydroalcohol, acetone, and hexane extracts of the leaves of Psidium guajava. The antimicrobial activity was measured by the agar well diffusion method. Gastric volume, pH, total and free acidity and the ulcerative index was also measured in hydroalcoholic extract of Psidium guajava on gastric ulcer pyloric ligation in rat. Glycosides, terpenoids, and tannins are only present in the hydro alcohol extract. The extracts are tested against gram-negative (Escherichia coli) and gram-positive (Staphylococcus aureus, Bacillus subtilis) bacterial strains. The zone of inhibition against microorganisms is direct proportional to the concentration of extract. Maximum zone of inhibition (24mm) against Staphylococcus aureus except hexane extract was seen. Psidium guajava leaves show maximum phytochemicals compounds and inhibition of microorganisms in hydroalcoholic extract. So the hydroalcoholic extraction was used for anti-ulcer activity. The present study was performed in pylorus ligation induced gastric ulcer model in albino rats in which the ability of hydroalcoholic extracts of Psidium guajava was tested at a dose level of 400 mg/kg body weight orally and compared with Ranitidine (10 mg/kg) as standard. From the results it is concluded hydro alcohol leaf extracts of Psidium guajava 400 mg/kg dose level showed significant anti-ulcer activity when compared to that of standard drug.

Sudha rameshwari.k assistant professor

Reverence, obedience, and the transmission of traditions/values from one generation to the next are some of the most profound human responsibilities for families, clans, and tribes. One of the values that is transmitted in many cultures is respect for elders. However, the ways values are expressed differ based on culture and religion.

Santosh kumar

This review was aimed to describe a new approach of healthcare performance strategy based on individual genetic variants. Personalized medicine is a model for health care which is a combination of preventive, personalized, participatory and predictive measures. It is an approach for a better treatment by identifying the disease causing genomics makeup of an individual. This work features key advancements in the improvement of empowering advances that further the objective of customized and precision medication and the remaining difficulties that, when tended to, may produce phenomenal abilities in acknowledging genuinely individualized patient consideration. Customized treatment for patients determined to have strong tumors has brought about a few advances as of late. To improve a multi-drug approach ready to coordinate DNA and RNA adjustment, proteomics and metabolomics will be essential. The execution of translational examinations dependent on fluid biopsy and organoids or xenografts to assess molecular changes because of clonal weight produced because of the utilization of target specialists or tumor heterogeneity would help in the recognition of systems of opposition, proposing opportunities for novel mixes. The investigation of massive data in oncology can profit altogether from being engaged by artificial intelligence and machine learning strategies.

Mediterranean journal of pharmacy and pharmaceutical sciences

Effective project management requires an understanding of how stakeholders are impacted by project failure. It draws attention to the effects on those involve finances, reputations, and emotions, assisting organizations in risk avoidance and fostering stakeholder satisfaction, trust, and long-term success. The purpose of this study is to provide proactive risk management, stakeholder involvement, and project result strategies. In order to compile this study, we have used a number literature reviews ranging from 2004 to 2023. The study's findings show that project failure results in significant financial losses, harms reputation, has legal ramifications, affects employee wellbeing, stifles relationships with stakeholders, stifles innovation, and endangers communities and the environment. By Adopting proactive risk management, strong governance, open communication, employee support, stakeholder involvement, strategic resource allocation, and social and environmental responsibility to reduce these negative effects and achieve sustainable project outcomes. The policymakers, practitioners and academia should focus risk factors those are associated with the project failure and hance manage a good harmony among the stakeholders.

Nazim ullah