Adverse drug reactions have increased significantly in people as many new drugs have come to the market in the last two decades. This has not only economic consequences but also causes morbidity and mortality. In Bangladesh, some incidents happened related to drug problems and it took several lives. Spontaneous reporting of adverse drug reactions can primarily control this situation and healthcare professionals can play an immeasurable role. Therefore, this study was aimed to be conducted at seven different hospitals and diagnostic centers to find out the actual scenario of adverse drug reactions among the healthcare professionals in Bangladesh to make them aware of adverse drug reactions and the reporting system, and to know about their opinion towards adverse drug reactions. However, after evaluation of the questionnaires it was found that a large number of healthcare professionals were not aware of adverse drug reactions and pharmacovigilance, especially the nurses. It was found that 13.3% of nurses did not know about adverse drug reactions and 93.3% of them had not reported any reactions. Furthermore, many healthcare professionals did not show a positive attitude towards pharmacovigilance. If proper pharmacovigilance practice cannot be started, the nation will face serious economic and health-related problems.

Mediterranean journal of pharmacy and pharmaceutical sciences

The purpose of this research was to examine the mediating effect of empowerment on the linkage between Total Quality Management (TQM) and service recovery performance in the hotel industry. Although much has been written about TQM, empowerment and service recovery performance, but the role of empowerment as a mediator in the relationship between TQM and service recovery performance has remained a relatively unexplored research area. A 93-item questionnaire is designed to measure TQM, empowerment and service recovery amongst employees in five-star hotels in Jordan, and 254 usable questionnaires were used in this study. Principal components analysis determined the factor structure and regression analysis determined the relationships between the study’s variables. The results revealed that the TQM implementations have positive effects on empowerment and service recovery performance. Moreover, the study found the full mediating effect of empowerment in the relationship between TQM and service recovery performance. Implications, limitations and future research are discussed at the end. This study proposes model of influence of TQM in service recovery performance, whereby empowerment fully mediates this relationship.

Mukhles m. al-ababneh

Immunoglobulin G4-related disease (IgG4-RD) is a rare and new but increasingly recognized immune-mediated fibroinflammatory condition known to affect multiple organs. The diagnostic approach is challenging, as there is no single investigation to confirm the diagnosis, which requires the integration of clinical, biochemical, and radiographic manifestations with classic histopathologic features to establish the diagnosis. The histology of IgG4-RD is determined by a dense lymphoplasmacytic infiltrate, storiform fibrosis, and obliterative phlebitis in the presence of an increased level of IgG4 in most patients. The first line of treatment is systemic glucocorticoids, but adverse effects of the drug, suboptimal response, and disease recurrences on reduction or termination of therapy highlight the need for an alternative therapy such as rituximab, which appears to be a promising alternate agent in the treatment of IgG4-RD; however, its efficacy needs to be evaluated in large clinically controlled trials.

Karishma

Along with computer technology, the demand of digital image processing is too high and it is used massively in every sector like organization, business, medical etc. Image segmentation enables us to analyze any given image in order to extract information from the image. There are numerous algorithm and techniques have been industrialized in the field of image segmentation. Segmentation has become one of the prominent tasks in machine vision. Machine vision enables the machine to vision the real world problems like human does and also act accordingly to solve the problem so it is utmost important to come up with the techniques that can be applied for the image segmentations. Invention of modern segmentation methods like instance, semantic and panoptic segmentation have advances the concept of machine vision. This paper focuses on the various methods of image segmentation along with its advantages and disadvantages.

Manoj kumar pandey

Monitoring and controlling of clean area environment is of paramount importance to ensure product safety and quality. This comprehensive analysis evaluates environmental monitoring (EM) data from Class C and Class D controlled environments in pharmaceutical manufacturing, utilizing Active Air (AA), Passive Air (PA), and Contact Plate (CP) or Replicate Organism Detection And Counting (RODAC) surface samples. The study aims to identify contamination trends, anomalies, and compliance with ISO 14644-1 and EU GMP Annex 1 standards. Results reveal unexpected findings: Class C Active Air (43 CFU/m³) and RODAC (3 CFU/plate) overall averages are higher than Class D Active Air (34 CFU/m³) and RODAC (2 CFU/plate), respectively, deviating from expected cleanroom classification. Class D Passive Air (22 CFU/plate) is higher than Class C (17 CFU/plate), aligning with expectations. Persistent hotspots were identified in Class C (e.g., location labelled “AA C 12 NG0”AA averages± Standard Deviation (SD): 67.33±17 CFU/m³), indicating localized control failures, while Class D showed extreme individual spikes (e.g., AA D 99 Ac: Max 171 CFU/m³). Sporadic contamination events in Class C suggest transient breaches, necessitating root-cause investigations. The study also highlights limitations of Class D monitoring, which obscures temporal trends and risks missing critical excursions due to long intervals between samples. Recommendations include targeted engineering assessments for high-load zones, enhanced Standard Operating Procedures (SOPs) for cleaning and gowning, adoption of real-time biofluorescent particle counters to replace manual sampling, and increased monitoring frequency in Class D hotspots.

Mostafa eissa

Hemophagocytic lymphohistiocytosis (HLH) is a distinct medical condition characterized by symptoms such as fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, and the presence of hemophagocytosis in the bone marrow and other organs. HLH can be classified as either hereditary or secondary, linked to various infections, autoimmune disorders, or cancers. The occurrence of malaria-associated HLH in newborns is considered rare. This report details a case involving a newborn diagnosed with mixed-type malaria complicated by HLH. The diagnosis was delayed because of the rare occurrence of malaria infections in Libya, which the treating clinicians did not initially take into account. The patient received supportive care and antimalarial treatment, which yielded excellent results, and was subsequently discharged from the hospital.

Karishma

The Nano-bio fusion is a booming area with high expectations that major steps in health treatment, body repair and body improvement can be made. It is regarded as the most innovative domain of this moment. Developments are in the field of: Nanomedicine: targeted drug delivery by medically functionalized nanoparticles, for rapid cure without side effects or human stimulation. Regenerative medicine: DNA programmed tissue engineering for quick and efficient wound healing, rebuilt of organs and other body parts. Smart implants: biocompatible implants that can sense and actuate in order to repair or enhance a body function. Nanotechnology idea has as of late gone into the exercises of day by day living. Nanotechnology in games solution cals be characterized as the adjustment of a wide range of improvements in nanoscale into therapeutic applications related with games wounds. The adjusted advancements can be either specifically related with the restorative mediations, for example, recovery of a tissue, implantation, and drug treatments or supporting components like imaging, strappings, and tapings. In this section, the impression of recently developed nanoscale advancements in regards to games wounds will be talked about with recent researches.

Yatendra sharma

The use of nanotechnology in healthcare and medicine is crucial, particularly for nanocoatings. The therapeutic potential of nanocoatings on medical implants and devices is examined in this chapter. It goes into the ingredients, production processes, and health benefits of nanocoatings. Device functionality and biocompatibility can be enhanced by nanocoatings. They are essential in addressing healthcare issues including cardiovascular stents and orthopedic implants. Additionally, nanocoatings are used in medication delivery systems, tissue engineering, and wound healing. This chapter offers important knowledge on the medical applications of nanocoatings to experts and researchers. Nanotechnology has the potential to alter the medical industry, which would be advantageous for patients.

Boopathy govindarajan

Therapies highly plays a crucial role for all those children and adults with disabilities. In this article, We aim to research the Special Educators’ Knowledge about Therapies in various special schools in the city of Hyderabad, Telangana, India. A qualitative approach was taken for this purpose. Questionnaires was used to collect the data. It was found that the teachers did not have proper conception on Therapies. The data indicated that the teachers are unaware about the unconventional therapies such as Drama Therapy, Pet Therapy and Laughter Therapy and there benefits when working with CSN. This lack of awareness needs to be addressed for the enhancement of the teacher as well students capabilities.

Husna habib

Blind Taste Test of Soft-drinks – A Comparison Study on Coke and PBrand equity is “The differential effect that brand knowledge has on consumer response to the marketing of that brand” (Keller-1993).Brand equity is the added value a product acquires as a result of past investments in the marketing activity for the brand.This marketing activity resides in the mind of customers and as a result customer shapes a perception about the brand, biggest challenge here is creating positive perceptions by ensuring that customers have right type of experiences with product so that both functional experiences as well as emotional experiences become associated with the product.Thus Brand perception is the imagewhich a brand creates in the mind of the customers due to the various associations linked with the brand. The simplest way tounderstand what brand equity is to understand the typical results of product sampling and comparison tests. One such test is blind taste test in which consumers sample a product without knowing the brand what they consume and consuming the same product knowing brand i.e., open test. When consumers report different opinions about branded and unbranded versions of identical products, it must be the case that knowledge about the brand has changed their perceptions. Thus, consumers’ perceptions of product performance are highly dependent on their impressions of the brand that goes along with it Pepsi

N ramanjaneyalu

Background General Government Health Expenditure (GGHE) in Mauritius accounted for only 10% of General Government Expenditure for the fiscal year 2018. This is less than the pledge taken under the Abuja 2001 Declaration to allocate at least 15% of national budget to the health sector. The latest National Health Accounts also urged for an expansion in the fiscal space for health. As public hospitals in Mauritius absorb 70% of GGHE, maximising returns of hospitals is essential to achieve Universal Health Coverage. More so, as Mauritius is bracing for its worst recession in 40 years in the aftermath of the COVID-19 pandemic public health financing will be heavily impacted. A thorough assessment of hospital efficiency and its implications on effective public health financing and fiscal space creation is, therefore, vital to inform ongoing health reform agenda. Objectives This paper aims to examine the trend in hospital technical efficiency over the period 2001–2017, to measure the elasticity of hospital output to changes in inputs variables and to assess the impact of improved hospital technical efficiency in terms of fiscal space creation. Methods Annual health statistics released by the Ministry of Health and Wellness and national budget of the Ministry of Finance, Economic Planning and Development were the principal sources of data. Applying Stochastic Frontier Analysis, technical efficiency of public regional hospitals was estimated under Cobb–Douglas, Translog and Multi-output distance functions, using STATA 11. Hospital beds, doctors, nurses and non-medical staff were used as input variables. Output variable combined inpatients and outpatients seen at Accident Emergency, Sorted and Unsorted departments. Efficiency scores were used to determine potential efficiency savings and fiscal space creation. Findings Mean technical efficiency scores, using the Cobb Douglas, Translog and Multi-output functions, were estimated at 0.83, 0.84 and 0.89, respectively. Nurses and beds are the most important factors in hospital production, as a 1% increase in the number of beds and nurses, result in an increase in hospital outputs by 0.73 and 0.51%, respectively. If hospitals are to increase their inputs by 1%, their outputs will increase by 1.16%. Hospital output process has an increasing return to scale. With technical efficiencies improving to scores of 0.95 and 1.0 in 2021–2022, potential savings and fiscal space creation at hospital level, would amount to MUR 633 million (US$ 16.2 million) and MUR 1161 million (US$ 29.6 million), respectively. Conclusion Fiscal space creation through full technical efficiency, is estimated to represent 8.9 and 9.2% of GGHE in fiscal year 2021–2022 and 2022–2023, respectively. This will allow without any restrictions the funding of the national response for HIV, vaccine preventable diseases as well as building a resilient health system to mitigate impact of emerging infectious diseases as experienced with COVID-19.

Ajoy nundoochan

Cervical and ovarian cancers contribute significantly to female morbidity and mortality worldwide. The current standard of treatment, including surgical removal, radiation therapy, and chemotherapy, offers poor outcomes. There are many side effects to traditional chemotherapeutic agents and treatment-resistant types, and often, the immune response is depressed. As a result, conventional approaches have evolved to include new alternative remedies, such as natural compounds. Aquatic species provide a rich supply of possible drugs. The potential anti-cancer peptides are less toxic to normal cells and can attenuate multiple drug resistance by providing a productive treatment approach. The physiological effects of marine peptides are described in this review, which focuses on various pathways, such as apoptosis, microtubule balance disturbances, suppression of angiogenesis, cell migration/invasion, and cell viability. The review also highlights the potential role of marine peptides as safe and efficacious therapeutic agents for treating cervical and ovarian cancers.

Dr. salman ahmed

A mental and behavioral illness is described as a clinically significant illness with changes in thought, emotion, or behavior related to a personal situation. Objectives of the study: To assess the knowledge regarding mental health & illness and level of stress. 2. To determine the effectiveness of Educational Intervention on knowledge regarding mental health & illness and level of stress 3. To find out the association between pre-test knowledge level on mental health & illness and selected demographic variables. 4. To find out the association between pre-test stress level and selected demographic variables. 5. To find out relation between knowledge score of mental health & Illness with stress level. Methodology: Quantitative research approach with pre-experimental research design was used. Sampling: 300 samples was chosen with consecutive sampling technique. Result: In pretest mean score for knowledge and stress were 8.9 and 27.9 respectively and post-test were 19.7 and 17.45 which showed that education intervention improve the knowledge and decrease stress among adolescent. Improved knowledge reduces stress level. Conclusion: Educational intervention improve knowledge level which significantly reduce level of stress.

Dr k c yadav

This study demonstrates main reasons for choosing The National University of Malaysia (UKM) by international students and their needs and expectations toward the University. The study also shows the obstacles faced by those students and their satisfaction towards UKM. A total of 108 questionnaires were distributed in the main campus to the respondents who came from ten diffident countries. The main reasons for choosing UKM were its high ranking, reasonable tuition fees, faculty, programmes, and lecturers respectively. The results revealed that the main obstacles faced international students were tough visa procedures, improper hostels, social isolation and discrimination, and bureaucracy. Both the facilities and services of UKM and the studying approach have met the expectations satisfaction of international students. Yet, both social relationship and participation in activities and living conditions in UKM hostels have disappointed international students and did not meet their satisfaction. This study suggested that UKM should establish counselling unit and organise regular meetings to listen to the problems and suggestions of those students. Volunteer and pre-enrolment activities should be organised to introduce the Malaysian culture and gather international students with their local peer. Moreover, international students should be provided upon their arrival to UKM by hostels that combine proper conditions of living at a reasonable price.

Mohammed fadel arandas

Lack of development of adequate social skills of special need students results in many disruptive behavior and poor academic gains. School setting is also an indicator of rise in academics and learning of social skills. The purpose of the current study was to investigate the social skills development and educational outcomes of special need students attending special and inclusive settings. Only 110 visually impaired students (60 from special and 50 form inclusive school setting) represent as special need children who participated as sample of the study. Data were collected from 5 Special Schools for Visually Impaired and 5 Inclusive Schools located in Delhi and NCR. Hindi Version of the Matson Evaluation of Social Skills with Youngsters: Self-rating form (MESSY) by Sharma (2000) was used to assess social skills development and to measure the educational outcome, aggregate percentage marks obtained by the students in their previous year‟s annual examination were collected from the records of the schools. Hypotheses formulated for this study were verified by applying appropriate statistical techniques- Mean, Standard Deviation and t-test. Significant differences found in the development of social skills and educational gains of the special need children in special vs. inclusive settings. Inclusive setting, to a great extent provides conducive learning environment and platform to develop social skills. Results of the study recommend implications for special and normal children, teachers and administrators.

Rubul kalita

Elevated arterial blood pressure is the most important public health problem in developed countries. It often leads to lethal complications if left untreated. Brewer's yeast is celebrated for its various beneficial effects, including a possible hypotensive effect. Thus, the anti-hypertensive effects of brewer’s yeast were investigated. The hypertensive model was done by a once-weekly intraperitoneal injection of dexamethasone at a dose of 25 mg/kg combined with drinking a 1.0% sodium chloride solution containing 0.2% KCl and 2.0% glucose for six weeks. The blood pressure was measured by the rat carotid artery cannulation preparation. Different doses of brewer's yeast dissolved in distilled water were injected into the internal jugular vein, with measurement of blood pressure at each time. To explore the mechanism of the hypotensive effect of yeast, the yeast cardiac effect was verified by the use of isolated perfused rabbit heart preparations using different antagonists. It was found that dexamethasone elevated systolic blood pressure to 178.3±11.6 and diastolic blood pressure to 133.3±16.6 from normal levels of 115.0±9.1 for systolic and 74.0±4.1 for diastolic. The gradual increase in intravenous yeast doses ranging from 0.05 to 0.40 effectively lowered systolic and diastolic blood pressure in rats with normal pressure, bringing them to approximately 80.0±05.6 mmHg for systolic and 40.0±3.5 mmHg for diastolic. While doses exceeding 0.04 resulted in a drop in systolic pressure to 60.0±3.9 mmHg, diastolic pressure became unrecordable. The administration of the 0.20 dose resulted in unrecordable blood pressure. In hypertensive rats, a decrease in blood pressure was observed with doses ranging from 0.60-1.0 mg, leading to a reduction to 110.0±2.8 mmHg for systolic and 52.0±9.9 mmHg for diastolic pressures. Doses exceeding 1.0 mg further lowered systolic and diastolic pressures to 20.0±3.9 mmHg. There was a mild increase in heart rate with no change in cardiac force of contraction. This effect was not mediated through beta, calcium receptors, or the histamine effect. The findings show that the yeast has a dose-dependent blood pressure-lowering effect. The mechanism of the chronotropic effect is possibly due to its direct action.

Mediterranean journal of pharmacy and pharmaceutical sciences

Background and Purpose: We aimed to investigate the effect of smoking on the risk of intracranial aneurysm (IA) rupture (IAR), specifically relationship between the number of cigarettes smoked per day (CPD) or smoking index and the risk of IAR. Materials and Methods: We performed a single-center case–control study of consecutive patients evaluated or treated for IA at our institution from June 2017 to July 2018. Cases were patients with a ruptured IA. Two age- and sex-matched controls with an unruptured IA were included per case. Conditional logistic regression models were used to assess the relationship between both the CPD and smoking index (CPD x years of smoking) and IAR. Results: The study population included 300 cases of IAR and 300 controls. The higher IAR risk was associated with cigarette smoking. Our subgroup analysis of smokers revealed a significant association between IAR risk and current smoking (OR, 2.8; 95% CI, 1.2–6.3; P = 0.012), current heavy smoking (CPD>20) (OR, 3.9; 95% CI, 1.4–11.0; P = 0.007), and a smoking index >800 (OR, 11.4; 95% CI, 2.3–24.5; P= 0.003). Conclusion: A dose–response relationship has been noted for intensity and duration of smoking consumption and increased risk of IAR. As smoking is modifiable, this finding is important to managing patients with IAs to quit or reduce smoking prior to life-threatening subarachnoid hemorrhage.

Kamal singh

Background: Phaseolus vulgaris, commonly known as kidney bean, has been studied previously for pharmacological properties such as antidiabetic, antioxidant, analgesic, anti-inflammatory, antifungal, and antibacterial properties. Various extracts of the seeds have been researched except fixed oils. Objective: Therefore, the present study aims to investigate the behavioral activity of fixed oil extracted from Phaseolus vulgaris seeds. Methodology: Hole board, light and dark, stationary rod and open field tests were used for behavioral evaluation. Four groups were made with seven mice in each : (1) Control = Normal saline 2ml/kg (2) Phaseolus vulgaris fixed oil = PVFO 2ml/kg (3) PVFO 4ml/kg (4) Diazepam (1mg/kg) as standard. All treatments were given orally 30 minutes before the performance of tests. In the hole board test, PVFO 4ml/kg decreased the number of head poking (p≤0.01). Results: In light and dark tests, PVFO in both doses reduced the time spent in the light compartment (p≤0.01). In the open field test, the number of peripheral lines crossed was decreased (p≤0.05), whereas in the stationary rod test, no effect was observed by any dose of PVFO. Conclusion: Results indicate that Phaseolus vulgaris fixed oil does not affect memory or learning in mice and may possess a dose-dependent sedative hypnotic effect.

Dr. salman ahmed

The present study is designed to determine the types of secondary metabolites in three selected seed powders using a fast, reliable, and non-destructive Near Infra Red spectroscopic analytical technique. NIRS analysis of Macrotyloma uniflorum (Lam.) Verdc., Phaseolus lunatus Linn., and Phaseolus vulgaris Linn., seed flours were used to qualitatively evaluate secondary metabolites. The fine powder of crude drug was directly applied to FOSS XDS near the infrared Rapid Content Analyzer. The adequately filled powdered sample in a disposable glass silicate vial closed with a plastic lid was centrally placed onto the Foss Rapid Content Analyzer sample presentation glass. The scanning of samples at ambient temperature gives NIR spectra within 30 seconds. The major proposed compounds in M. uniflorum were 3,4-dihydroxybenzoic acid, caffeic acid, chlorogenic acid, ferulic acid, gallic acid, kaempferol, linolenic acid, niacin, quercetin, sinapinic acid, syringic acid, and vanillic acid. Whereas coumaric acid, fructose, galactose, L-serine, raffinose, stachyose, sucrose, threonine, and tyrosine were detected in P. lunatus, and the NIR suggested the presence of caffeic acid, ferulic acid, sinapinic acid, phytic acid, leucine, and valine in P. vulgaris. NIRS is an advanced innovative technology extensively used in chemical, food, petrochemical, and pharmaceutical industries for rapid and reliable standardization. The present study revealed an excellent correlation to conclude that flour samples of all three legume seeds could be added to the food system to achieve nutritional and functional benefits.

Dr. salman ahmed

Cardiovascular disease (CVD) remains the leading reason of death among patients with diabetes mellitus (DM). Individuals with DM have a two to five time's greater risk of developing CVD than non-DM. Unfortunately, little data exists on Libya's prevalence and characteristics of cardiovascular risk factors. This study aimed to evaluate the cardiovascular risk factors and to assess their control among patients with type 2 DM (T2DM). All the patients with T2DM who attended the outpatient clinic at National Diabetes Hospital from September 2013 to April 2022 were interviewed and examined and included in this study. Demographical data age, smoking habit, body mass index measure, drug intake, history of previous cardiovascular events, blood pressure and fasting lipid profile were all recorded. 1049 patients have completed the study with a mean age of 54.06 ± 14.5 years old (females represented 68.0% of the studied sample size), there were different duration of diabetes between the studied sample, varying from newly diagnosed patients (n = 265, 25.2%) and above ten years of diabetes duration patients (n = 488, 46.5%). Active smoking in 129 patients (12.3%), the bodyweight of studied patients ranged from 44.0 Kg to 186 Kg (85.65 ± 1.73), 820 of the patients had uncontrolled body weight (78.85%). Uncontrolled blood pressure, even with treatment, was found in 304 patients (29.0%), uncontrolled dyslipidaemia in 45 patients (04.3%), and uncontrolled hyperglycaemia in 816 patients (77.9%). Established CVD was positive in 295 patients (28.2%), maximum age group was in 54 - 74 years (n = 516, 49.3%). The most typical age group with multiple (more than three) CVD risk factors was 54 - 74 years of age, were female patients with more than ten years of history of diabetes, uncontrolled hyperglycemia (HBA1c > 10%), uncontrolled body weight, uncontrolled blood pressure and dyslipidemia. Thus, the present data indicated that Libyan patients with diabetes mellitus have high CVD risk factors. Even in patients with previous events, these uncontrolled risk factors elevate the likelihood of repeated cardiovascular events. Patients with diabetes mellitus necessitate a more aggressive approach to control the modified risk factors such as hypertension, dyslipidemia, obesity and smoking.

Mediterranean journal of pharmacy and pharmaceutical sciences